全文获取类型
收费全文 | 59篇 |
免费 | 7篇 |
国内免费 | 1篇 |
专业分类
妇产科学 | 3篇 |
基础医学 | 6篇 |
口腔科学 | 4篇 |
临床医学 | 8篇 |
内科学 | 23篇 |
皮肤病学 | 1篇 |
神经病学 | 6篇 |
外科学 | 1篇 |
预防医学 | 6篇 |
药学 | 3篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 11篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 9篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 4篇 |
2013年 | 2篇 |
2012年 | 7篇 |
2011年 | 3篇 |
2010年 | 5篇 |
2009年 | 1篇 |
2004年 | 1篇 |
2002年 | 2篇 |
2001年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
1956年 | 1篇 |
排序方式: 共有67条查询结果,搜索用时 15 毫秒
31.
32.
DM Baron M Clerte P Brouckaert MJ Raher AW Flynn H Zhang EA Carter MH Picard KD Bloch ES Buys M Scherrer-Crosbie 《Circulation. Cardiovascular imaging》2012,5(5):652-659
Background- Interventions to increase brown adipose tissue (BAT) volume and activation are being extensively investigated as therapies to decrease the body weight in obese subjects. Noninvasive methods to monitor these therapies in animal models and humans are rare. We investigated whether contrast ultrasound (CU) performed in mice could detect BAT and measure its activation by monitoring BAT blood flow. After validation, CU was used to study the role of uncoupling protein 1 and nitric oxide synthases in the acute regulation of BAT blood flow. Methods and Results- Blood flow of interscapular BAT was assessed in mice (n=64) with CU by measuring the signal intensity of continuously infused contrast microbubbles. Blood flow of BAT estimated by CU was 0.5±0.1 (mean±SEM) dB/s at baseline and increased 15-fold during BAT stimulation by norepinephrine (1 μg·kg(-1)·min(-1)). Assessment of BAT blood flow using CU was correlated to that performed with fluorescent microspheres (R(2)=0.86, P<0.001). To evaluate whether intact BAT activation is required to increase BAT blood flow, CU was performed in uncoupling protein 1-deficient mice with impaired BAT activation. Norepinephrine infusion induced a smaller increase in BAT blood flow in uncoupling protein 1-deficient mice than in wild-type mice. Finally, we investigated whether nitric oxide synthases played a role in acute norepinephrine-induced changes of BAT blood flow. Genetic and pharmacologic inhibition of nitric oxide synthase 3 attenuated the norepinephrine-induced increase in BAT blood flow. Conclusions- These results indicate that CU can detect BAT in mice and estimate BAT blood flow in mice with functional differences in BAT. 相似文献
33.
Robin Ruiz Matthias Schlund Gwénaël Raoul Maéva Kyheng Christian Fontaine Romain Nicot 《Journal of cranio-maxillo-facial surgery》2018,46(12):2256-2260
Purpose
The purpose of our anatomical study was to compare the accessibility of the area at the level of the neck of the condyle and the condylar head by two different approaches: the modified Risdon approach and a transparotid approach by rhytidectomy (TPAR).Methods
An anatomical study was performed on 12 heads of cadavers preserved with a solution rich in glycerin and ethanol, but very low in formalin. A modified Risdon approach and a TPAR were each performed on a hemiface of the same head. The bone surface was rendered digitally accessible on an anatomical diagram using Image J software. The software was used to determine a concordance score between the area of accessibility and the area of interest necessary for osteosynthesis of a high subcondylar fracture. This score was presented as a numerical scale from 0 to 100. We measured the total number of pixels in our area of interest and assigned it a score of 100. We then compared the area of accessibility with the area of interest necessary for osteosynthesis of a high subcondylar fracture.Results
Using the modified Risdon approach, an average score of 55.88 (SD = 18.96) was found, or 55.88% of the accessible area of interest. Using TPAR, we found a score of 91.05 (SD = 7.95) or 91.05% of the accessible area of interest. This difference in score between the two techniques was significantly different (p < 0.001), taking into account intra-hemiface and intra-individual correlation.Conclusion
TPAR seems to be more effective in treating high condylar process fractures of the mandible. 相似文献34.
Manon Dupleichs Martial Masson Olivier Gauthier Maeva Dutilleul Jean-Michel Bouler Elise Verron Pascal Janvier 《The journal of pain》2018,19(10):1169-1180
Postoperative pain after bone reconstruction is a serious complication that could jeopardize the global success of a surgery. This pain must be controlled and minimized during the first 3 to 4 postoperative days to prevent it from becoming chronic. In this study, a critical-size bone defect was created at the femoral distal end of rats and filled by an injectable calcium phosphate cement (CPC) loaded or not with local anesthetics (bupivacaine or ropivacaine). A functional evaluation of the gait was performed using the CatWalk system to compare the postoperative pain relief enhanced by the different CPCs after such a bone filling surgery. The results demonstrated significant pain relief during the short-term postoperative period, as shown by the print area and intensity parameters of the operated paw. At 24hours, the print area decreased by 65%, 42%, and 24%, and the intensity decreased by 25%, 9%, and 1% for unloaded, ropivacaine-loaded, and bupivacaine-loaded CPCs, respectively, compared with the preoperative values. Bupivacaine-loaded CPC provided an earlier return to full functional recovery than ropivacaine-loaded CPC. Moreover, the CPCs retained their biologic and mechanical properties. For all these reasons, anesthetic-loaded CPCs could be part of the global pain management protocol after bone reconstruction surgery such as iliac crest bone grafting procedures.
Perspective
Bupivacaine-loaded CPC provided an earlier return to full gait function than ropivacaine-loaded CPC, with preserved bone filling properties. Such analgesic CPCs deserve further in vivo investigation and may be part of the global pain management protocol after bone reconstruction or bone augmentation surgery such as iliac crest bone grafting. 相似文献35.
Self‐reported cue‐induced physical symptoms of craving as an indicator of cocaine dependence
下载免费PDF全文
![点击此处可从《The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Florence Vorspan MD PhD Maeva Fortias MD Msc El‐hadi Zerdazi MD Msc Emily Karsinti MA Vanessa Bloch PharmD PhD Jean‐Pierre Lépine MD Frank Bellivier MD PhD Georges Brousse MD PhD Wim van den Brink MD PhD Eske M. Derks PhD 《The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions》2015,24(8):740-743
36.
37.
Nicolas J Guehl Karla M Ramos-Torres Clas Linnman Sung-Hyun Moon Maeva Dhaynaut Moses Q Wilks Paul K Han Chao Ma Ramesh Neelamegam Yu-Peng Zhou Brian Popko John A Correia Daniel S Reich Georges El Fakhri Peter Herscovitch Marc D Normandin Pedro Brugarolas 《Journal of cerebral blood flow and metabolism》2021,41(7):1721
Demyelination causes slowed or failed neuronal conduction and is a driver of disability in multiple sclerosis and other neurological diseases. Currently, the gold standard for imaging demyelination is MRI, but despite its high spatial resolution and sensitivity to demyelinated lesions, it remains challenging to obtain specific and quantitative measures of molecular changes involved in demyelination. To understand the contribution of demyelination in different diseases and to assess the efficacy of myelin-repair therapies, it is critical to develop new in vivo imaging tools sensitive to changes induced by demyelination. Upon demyelination, axonal K+ channels, normally located underneath the myelin sheath, become exposed and increase in expression, causing impaired conduction. Here, we investigate the properties of the K+ channel PET tracer [18F]3F4AP in primates and its sensitivity to a focal brain injury that occurred three years prior to imaging. [18F]3F4AP exhibited favorable properties for brain imaging including high brain penetration, high metabolic stability, high plasma availability, high reproducibility, high specificity, and fast kinetics. [18F]3F4AP showed preferential binding in areas of low myelin content as well as in the previously injured area. Sensitivity of [18F]3F4AP for the focal brain injury was higher than [18F]FDG, [11C]PiB, and [11C]PBR28, and compared favorably to currently used MRI methods. 相似文献
38.
39.
Denisova LA Nasyrova NV Maev RG Grigor'ian AS Grigor'iants LA Denisov AA Grineva TV Maeva EIu Severin FM 《Stomatologii?a》2002,81(1):26-30
The structure of filling materials (kemfil, polyacrylate cement, and Dentis, material produced by Stomadent Firm in Russia) at the interface with human dentin was studied in teeth subjected to retrograde filling with preliminary appendectomy. A prototype of table wide-field short pulse scanning acoustic microscope (50 mHz) (Acoustic Microscopy Center, Institute of Biochemical Physics of Russian Academy of Sciences) and Elsam acoustic microscope (200 mHz) (Leitz, Germany) were used. The results indicate that analysis of acoustic characteristics, including the data of acoustic microscopy, helps investigate the cement microstructure and evaluate the compactness and elasticity of samples; moreover, structural elements of the material, which are undetectable by other methods, are seen on acoustic images. These data can be used for evaluating the relationship between the microstructure and formation of mechanical properties, and, maybe, the patterns of cement interactions with dental tissues. 相似文献
40.