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51.
Effects of intracisternal endothelin-1 injection on blood flow to the lower brain stem. 总被引:2,自引:0,他引:2
I Macrae M Robinson M McAuley J Reid J McCulloch 《European journal of pharmacology》1991,203(1):85-91
The central effects of endothelin-1 (Et-1, 10-30 pmol in 2.5 microliters injected intracisternally) have been investigated in the conscious rat. With 10 and 20 pmol Et-1, no significant change in blood pressure was observed. With 30 pmol Et-1, mean arterial blood pressure rose by 40 +/- 10 mm Hg with an accompanying modest, short-lived bradycardia at 2 min post-injection. Cerebral blood flow [( 14C]iodoantipyrine autoradiography), measured simultaneously with the hypertensive response, was markedly reduced throughout the caudal medulla and cerebellum (by up to 85%), while significant hyperaemia was evident in a number of forebrain structures (e.g. an increase of 78% in sensorimotor cortex). These observations have relevance to two distinct scientific areas. Concerning the significant effect of Et-1 in central cardiovascular control, these results caution against drawing conclusions from ventricular application with knowledge only of cardiovascular parameters. These results also illustrate the profound effects of Et-1 which is uniquely capable of overriding cerebral autoregulatory mechanisms. 相似文献
52.
The requirements for hearing aid frequency responses, SSPL characteristics, compression limiting, directional response, and internal noise are examined. On the basis of the assumptions made, aids would best serve the hearing impaired if they had flat very-low-frequency gains (and various mid- and high-frequency gains), SSPL responses adjustable in shape and level, directional responses, and internal noise levels below a recommended criterion level. 相似文献
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IM Gardiner F Ahmed TJ Steiner A McBain C Kennard J de Belleroche 《Cephalalgia : an international journal of headache》1998,18(4):192-196
The project was an investigation into whether changes in the expression of G-proteins underlie altered cell signaling in migraine and cluster headache. The basis for this assumption is that altered physiological responses are seen in migraineurs and that differences in cell signaling are detected biochemically in various cell types isolated from peripheral blood. Levels of three G-protein mRNAs—Gsα, Giα, and Gqα were quantified in lymphocytes from clinically well-defined migraine and cluster headache patients and correlated with headache type and influence of drug treatment. Giα mRNA was reduced by 50% in all migraine patients compared with control subjects; similarly in patients with or without aura, in patients with a migraine headache at the time of sampling, and patients in a quiescent state. No reduction in the levels of Gsα or Gqα mRNA were seen in migraine patients. A smaller reduction was seen in cluster headache patients, most marked in those without medication. Levels of Gsα. mRNA were significantly reduced in cluster headache patients compared with migraine patients. The marked down-regulation of Giα mRNA in migraine, whether quiescent or acute, indicates either an adaptive response to headache in this group of patients or that low levels of Giα mRNA make individuals more susceptible to migraine. 相似文献
56.
Fluconazole levels in plasma and vaginal secretions of patients after a 150-milligram single oral dose and rate of eradication of infection in vaginal candidiasis. 总被引:3,自引:1,他引:3
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E T Houang O Chappatte D Byrne P V Macrae J E Thorpe 《Antimicrobial agents and chemotherapy》1990,34(5):909-910
Mean peak concentrations of fluconazole in plasma and vaginal secretions of females after a 150-mg single oral dose were shown to be 2.82 micrograms/ml and 2.43 micrograms/g, respectively. Our results indicate that clinically efficacious concentrations of fluconazole in vaginal secretions are easily achieved after this single oral dose. 相似文献
57.
Recent neuroimaging research has linked the task of forming a "person impression" to a distinct pattern of neural activation that includes dorsal regions of the medial prefrontal cortex (mPFC). Although this result suggests the distinctiveness of social cognition - the processes that support inferences about the psychological aspects of other people - it remains unclear whether mPFC contributions to this impression formation task were person specific or if they would extend to other stimulus targets. To address this unresolved issue, participants in the current study underwent fMRI scanning while performing impression formation or a control task for two types of target: other people and inanimate objects. Specifically, participants were asked to use experimentally-provided information either to form an impression of a person or an object or to intentionally encode the sequence in which the information was presented. Results demonstrated that activation in an extensive region of dorsal mPFC was greater for impression formation of other people than for all other trial types, suggesting that this region specifically indexes the social-cognitive aspects of impression formation (i.e., understanding the psychological characteristics of another mental agent). These findings underscore the extent to which social cognition relies on distinct neural mechanisms. 相似文献
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Daniel D. Buchanan Kevin Sweet Musa Drini Mark A. Jenkins Aung Ko Win Michael Gattas Michael D. Walsh Mark Clendenning Diane McKeone Rhiannon Walters Aedan Roberts Alasdair Young Heather Hampel John L. Hopper Jack Goldblatt Jill George Graeme K. Suthers Kerry Phillips Graeme P. Young Elizabeth Chow Susan Parry Sonja Woodall Kathy Tucker Amanda Muir Michael Field Sian Greening Steven Gallinger Jane Green Michael O. Woods Renee Spaetgens Albert de la Chapelle Finlay Macrae Neal I. Walker Jeremy R. Jass Joanne P. Young 《International journal of colorectal disease》2010,25(12):1513-1515