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This is the sixth hypertension guideline published by the Southern African Hypertension Society (SAHS). Currently 30.4% of the adult population have hypertension (HTN),1 necessitating a simplified approach to assessment and treatment, which reflects realistic objectives that can be implemented by medical practitioners, nurse practitioners and pharmacists to diminish the impact of HTN and related cardiovascular disease (CVD) risk in this country. For full details on management not contained in this document please refer to the more detailed hypertension guideline 2011.2 相似文献
433.
Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case‐Control Sequencing Studies 下载免费PDF全文
Nicholas B. Larson Shannon McDonnell Lisa Cannon Albright Craig Teerlink Janet Stanford Elaine A. Ostrander William B. Isaacs Jianfeng Xu Kathleen A. Cooney Ethan Lange Johanna Schleutker John D. Carpten Isaac Powell Joan Bailey‐Wilson Olivier Cussenot Geraldine Cancel‐Tassin Graham Giles Robert MacInnis Christiane Maier Alice S. Whittemore Chih‐Lin Hsieh Fredrik Wiklund William J. Catolona William Foulkes Diptasri Mandal Rosalind Eeles Zsofia Kote‐Jarai Michael J. Ackerman Timothy M. Olson Christopher J. Klein Stephen N. Thibodeau Daniel J. Schaid 《Genetic epidemiology》2016,40(6):461-469
Rare variants (RVs) have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional single‐marker methods for statistical analysis are underpowered for typical sequencing study sample sizes. Multimarker burden‐type approaches attempt to identify aggregation of RVs across case‐control status by analyzing relatively small partitions of the genome, such as genes. However, it is generally the case that the aggregative measure would be a mixture of causal and neutral variants, and these omnibus tests do not directly provide any indication of which RVs may be driving a given association. Recently, Bayesian variable selection approaches have been proposed to identify RV associations from a large set of RVs under consideration. Although these approaches have been shown to be powerful at detecting associations at the RV level, there are often computational limitations on the total quantity of RVs under consideration and compromises are necessary for large‐scale application. Here, we propose a computationally efficient alternative formulation of this method using a probit regression approach specifically capable of simultaneously analyzing hundreds to thousands of RVs. We evaluate our approach to detect causal variation on simulated data and examine sensitivity and specificity in instances of high RV dimensionality as well as apply it to pathway‐level RV analysis results from a prostate cancer (PC) risk case‐control sequencing study. Finally, we discuss potential extensions and future directions of this work. 相似文献
434.
Effects of lipid A and liposomes containing lipid A on platelet and fibrinogen production in rabbits 总被引:3,自引:0,他引:3
The effect of the lipid A moiety of endotoxin on platelet and fibrinogen production was studied in rabbits. Lipid A was infused intravenously in doses ranging from 1 to 100 micrograms/kg body mass; 18 hr later, selenomethionine-75Se was injected intravenously and its incorporation into fibrinogen and platelets determined. Lipid A in saline stimulated fibrinogen and platelet production, but the dose required was 50--100 times that required for an intact endotoxin. Although lipid A solubilized in triethylamine (TEA) was at least 60 times more active in the Limulus amebocyte lysate assay than was lipid A suspended in saline, the sensitivity of platelet and fibrinogen production to solubilized lipid A was increased only twofold. Incorporation of lipid A into liposomes had no effect on its Limulus activity. Lipid A in liposomes continued to stimulate platelet, but not fibrinogen, production. Leukopenia that was induced by lipid A in TEA did not occur when rabbits received the same dose of lipid A in liposomes. Lipid A, like intact endotoxin, can stimulate platelet and fibrinogen production and induce leukopenia but the doses required are high. The low solubility of lipid A in aqueous solutions may be only one factor that determines its biologic activity. 相似文献
435.
Two-dimensional iodopeptide mapping demonstrates that erythrocyte Rh D, c, and E polypeptides are structurally homologous but nonidentical 总被引:8,自引:0,他引:8
Blanchard D; Bloy C; Hermand P; Cartron JP; Saboori AM; Smith BL; Agre P 《Blood》1988,72(4):1424-1427
The 32,000 molecular weight (mol wt) erythrocyte Rh D, c, and E polypeptides were separately purified from cDE/cDE erythrocytes by monoclonal immunoprecipitations and compared by two-dimensional iodopeptide mapping. Digestions of the isolated Rh polypeptides with alpha-chymotrypsin revealed a high degree of structural homology between c and E (13/14 iodopeptides were identical) and less striking homology between D and c or E (8/19 identical). The iodopeptide maps of Rh proteins purified by a nonimmunologic protocol from cDE/cDE erythrocytes were virtually identical to the composite pattern (D + c + E) deduced from the individual maps of Rh D, c, and E iodopeptides. Digestions of the isolated Rh polypeptides with trypsin revealed an overall homology of approximately 50% between iodopeptides derived from D, c, and E. These data indicate that the erythrocyte Rh D, c, and E antigens are carried by homologous but distinct molecular species; c and E appear more closely related to each other than to D. 相似文献
436.
Basiri Zohreh Yang Yi Bruinsma Fiona J. Nowak Anna K. McDonald Kerrie L. Drummond Katharine J. Rosenthal Mark A. Koh Eng-Siew Harrup Rosemary Hovey Elizabeth Joseph David Benke Geza Leonard Robyn MacInnis Robert J. Milne Roger L. Giles Graham G. Vajdic Claire M. Lynch Brigid M. 《Cancer causes & control : CCC》2022,33(5):749-757
Cancer Causes & Control - High-grade disease accounts for?~?70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or... 相似文献
437.
Mary Beth Terry Yuyan Liao Alice S Whittemore Nicole Leoce Richard Buchsbaum Nur Zeinomar Gillian S Dite Wendy K Chung Julia A Knight Melissa C Southey Roger L Milne David Goldgar Graham G Giles Sue-Anne McLachlan Michael L Friedlander Prue C Weideman Gord Glendon Stephanie Nesci Robert J MacInnis 《The lancet oncology》2019,20(4):504-517
438.