全文获取类型
收费全文 | 208篇 |
免费 | 5篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 2篇 |
基础医学 | 10篇 |
临床医学 | 14篇 |
内科学 | 38篇 |
皮肤病学 | 3篇 |
神经病学 | 12篇 |
特种医学 | 5篇 |
外科学 | 16篇 |
预防医学 | 72篇 |
药学 | 7篇 |
中国医学 | 1篇 |
肿瘤学 | 31篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 1篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2017年 | 1篇 |
2016年 | 8篇 |
2015年 | 2篇 |
2014年 | 11篇 |
2013年 | 5篇 |
2012年 | 28篇 |
2011年 | 32篇 |
2010年 | 9篇 |
2009年 | 9篇 |
2008年 | 7篇 |
2007年 | 14篇 |
2006年 | 15篇 |
2005年 | 10篇 |
2004年 | 7篇 |
2003年 | 7篇 |
2002年 | 4篇 |
2001年 | 1篇 |
2000年 | 4篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
排序方式: 共有213条查询结果,搜索用时 15 毫秒
31.
Jenab M Riboli E Ferrari P Friesen M Sabate J Norat T Slimani N Tjønneland A Olsen A Overvad K Boutron-Ruault MC Clavel-Chapelon F Boeing H Schulz M Linseisen J Nagel G Trichopoulou A Naska A Oikonomou E Berrino F Panico S Palli D Sacerdote C Tumino R Peeters PH Numans ME Bueno-de-Mesquita HB Büchner FL Lund E Pera G Chirlaque MD Sánchez MJ Arriola L Barricarte A Quirós JR Johansson I Johansson A Berglund G Bingham S Khaw KT Allen N Key T Carneiro F Save V Del Giudice G Plebani M Kaaks R 《British journal of cancer》2006,95(3):406-415
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma beta-cryptoxanthin (odds ratio (OR) = 0.53, 95% confidence intervals (CI) = 0.30-0.94, P(trend) = 0.006), zeaxanthin (OR = 0.39, 95% CI = 0.22-0.69, P(trend) = 0.005), retinol (OR = 0.55, 95% CI = 0.33-0.93, P(trend) = 0.005) and lipid-unadjusted alpha-tocopherol (OR = 0.59, 95% CI = 0.37-0.94, P(trend) = 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted alpha-tocopherol (OR = 0.26, 95% CI = 0.11-0.65, P(trend) = 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and alpha-tocopherol are associated with reduced risk of GC. 相似文献
32.
Khelifi S Bouhafa A Agrebi W Cherif A Ben M Khayat O Letaief A 《La Tunisie médicale》2006,84(2):128-130
Peutz-Jeghers syndrome is a hereditary affection with dominant autosomal transmission. The risk of cancerisation is largely higher than that in the general population. Dysplasia is rare. Transformation of the polyposis hamartoma into a site of dysplasia then into adenocarcinoma has been rarely reported. The authors report the case of a 14 year-old patient, having a severe dysplasia on ileal polyposis hamartoma related to the syndrome of Peutz-Jeghers. 相似文献
33.
Objective
To determine in real-life conditions the safety of treatment with rituximab (RTX) in patients with rheumatoid arthritis (RA) regarding malignancies.Methods
Analysis of safety data from a cohort of RA patients who received at least one course of RTX. RA patients with previous malignancies were followed-up and compared to the group of patients with no history of malignancy.Results
One hundred and eighty-six RA patients, 33 (17.7%) males, the mean age and disease duration were 55.8 ± 13.0 and 14.5 ± 11.1 years, respectively. The mean follow-up was 22.3 ± 15.1 months, corresponding to a follow-up of 346 pt-years of RTX exposure. Among these, 24 (12.9%) patients had a history of a prior malignancy. Five cancers were diagnosed during follow-up with four new malignancies (1 prostate, 1 breast, 1 colon and 1 cervical cancers) and one recurrence of a known breast cancer. The overall cancer rate was 1.45/100 pt-years (95%CI: 0.19 to 2.70), which is comparable to previously studied DMARD-treated cohorts. No new hematopoietic neoplasms were reported and the six lymphomas that have been in remission prior to RTX-therapy remained under follow-up. The baseline demographic and disease characteristics and the cancer-risk of the 24 patients who presented with a prior malignancy were similar to those with no cancer history (162 patients).Conclusions
Although based on a modest number of observed cancers, and despite selection bias (12.9% of prior malignancies in our RTX treated RA), this observational study suggests that RTX does not increase the cancer risk in RA patients. 相似文献34.
M. Moukram Z. Fahmy M. Belhallaj F. Slimani A. Chekkoury-Idrissi 《Journal africain du cancer / African Journal of Cancer》2014,6(3):174-177
Introduction
Ewing’s sarcoma reached preferentially long bones; the primary involvement of the mandibular condyle is rare, causing diagnostic and therapeutic challenges. We report a case of Ewing’s sarcoma of the mandibular condyle.Observation
A 37 year-old woman consulting for pain in the right temporomandibular articulation preceded by the extraction of tooth #18. The evolution was marked by the appearance of swelling of the parotid region. A CT-scan was done and objectified lytic aspect of the right condyle of the mandible. Resection was performed and histological examination of the surgical specimen showed a round cell tumor proliferation; CD99 immunostaining was positive and the assessment of extension was normal. Management was complemented by an expanded chemo-radiotherapy resection.Discussion
Ewing’s sarcoma is a round cell tumor with high-grade malignity, causing diagnostic and therapeutic difficulties. Clinical appearance is polymorphic, and pathological examination is not specific, evoking several differential diagnoses. Diagnostic confirmation involves techniques of molecular biology. 相似文献35.
Menvielle G Kunst AE van Gils CH Peeters PH Boshuizen H Overvad K Olsen A Tjonneland A Hermann S Kaaks R Bergmann MM Illner AK Lagiou P Trichopoulos D Trichopoulou A Palli D Berrino F Mattiello A Tumino R Sacerdote C May A Monninkhof E Braaten T Lund E Quirós JR Duell EJ Sánchez MJ Navarro C Ardanaz E Borgquist S Manjer J Khaw KT Allen NE Reeves GK Chajes V Rinaldi S Slimani N Gallo V Vineis P Riboli E Bueno-de-Mesquita HB 《American journal of epidemiology》2011,173(1):26-37
The authors investigated the role of known risk factors in educational differences in breast cancer incidence. Analyses were based on the European Prospective Investigation Into Cancer and Nutrition and included 242,095 women, 433 cases of in situ breast cancer, and 4,469 cases of invasive breast cancer. Reproductive history (age at first full-term pregnancy and parity), exposure to endogenous and exogenous hormones, height, and health behaviors were accounted for in the analyses. Relative indices of inequality (RII) for education were estimated using Cox regression models. A higher risk of invasive breast cancer was found among women with higher levels of education (RII = 1.22, 95% confidence interval (CI): 1.09, 1.37). This association was not observed among nulliparous women (RII = 1.13, 95% CI: 0.84, 1.52). Inequalities in breast cancer incidence decreased substantially after adjusting for reproductive history (RII = 1.11, 95% CI: 0.98, 1.25), with most of the association being explained by age at first full-term pregnancy. Each other risk factor explained a small additional part of the inequalities in breast cancer incidence. Height accounted for most of the remaining differences in incidence. After adjusting for all known risk factors, the authors found no association between education level and risk of invasive breast cancer. Inequalities in incidence were more pronounced for in situ breast cancer, and those inequalities remained after adjustment for all known risk factors (RII = 1.61, 95% CI: 1.07, 2.41), especially among nulliparous women. 相似文献
36.
37.
38.
39.