Opinions on treatment of women with habitual abortion based on investigations for blocking antibody and autoantibodies.

Three hundred and thirty-seven women with habitual abortion of unknown etiology were studied for cellular reactivity and blocking antibody in one-way mixed lymphocyte culture. Their sera were investigated for anti-cardiolipin antibodies, antinuclear antibodies, and antibodies against DNA, and the activated partial thromboplastin time (APTT) and complement levels of their plasma were determined. Increased anti-cardiolipin antibody levels were demonstrated in 77 (22%) of the 337 women, all of whom were considered healthy and had no signs of autoimmune disease. Most patients with high anti-cardiolipin antibody levels displayed lowered values of complement factor C4. According to our experiences, the mere occurrence of anti-cardiolipin antibody in women with habitual abortion is no absolute cause for treatment with prednisolone, not even in cases with greatly elevated anti-cardiolipin values. Therapy with prednisolone and acethylsalicylic acid (ASA) during pregnancy should be given to those women who have high levels of anti-cardiolipin antibodies concomitant with high APTT values, low values of complement C4, and strong blocking antibody. Anti-cardiolipin antibody has been investigated during pregnancy in 136 normal pregnant women, 11 of whom (8%) were positive at any sampling occasion, but only one of whom (1%) had high levels. Evidently the development of anti-cardiolipin antibody is no normal feature of pregnancy among Swedish women and thus the high frequency found among healthy Swedish women with habitual abortion remains unexplained. We have introduced an immunization program of leukocyte transfusions in habitual abortion. The development of previously absent blocking antibody seems to be a valuable prognostic sign of possible success for immunization therapy against habitual abortion.     

Non-disjunction in trisomy 21: study of chromosomal heteromorphisms in 110 families

QM variants on chromosome 21 and silver staining of NOR regions were applied in the study of non-disjunction in 110 families from different parts of Denmark. In 76% of the families the study was informative. Paternal failures were observed in 11 % on Funen as compared 23.5% on Zealand. In one family, crossing-over on the short arms of chromosome 21 in the mother and mitotic non-disjunction of chromosome 21 was observed.
Maternal first meiotic error predominates in both high maternal and low maternal age. Also in paternal non-disjunction failures of first meiotic division predominate. Two maternally and one paternally originated cases of de novo translocations were observed.     

CHANGES IN CONSUMER CONCERNS REGARDING FOOD SAFETY AND TRUST IN NUTRITION EXPERTS’ ADVICE

There has been an increasing emphasis on health risk in the public debate about food, and consumers are constantly exposed to conflicting sources of information about food safety and healthy diets. This may create uncertainty among consumers and affect food choice. This study aims to evaluate change in consumers’ perception of food safety and in trust in nutrition experts’ advice, as well as consumer awareness of health issues regarding food and the degree to which they take health into consideration when choosing food for their everyday meals. This report is based on two cross-sectional, interviewer-administered surveys of nationally representative samples of the Norwegian population over 15 years of age, conducted in 1994 (n=1048) and 1999 (n=999). The data were analyzed with the use of factor analysis, t-tests, ANOVA, and logistic regression. Consumers’ uncertainty about food safety increased and trust in expert advice declined. Fewer consumers considered fat-rich foods to be a part of a healthy diet in1999 and fewer reported having health considerations in mind when making everyday food choices. Uncertainty was unrelated to consumer food choice, whereas trust had implications for the degree to which consumers chose what they believed to be a healthy diet. In conclusion, the results have shown that the decline in trust in expert advice may have important implications as to whether or not consumers use their nutritional knowledge in the choice of foods for their everyday meals.     

Cognitive, mood and quality of life impairments in a select population of ARDS survivors

Background and objective:   There is increasing evidence that survivors of ARDS may have impairments in cognitive function, mood and quality of life. This study investigated associations between cognitive impairment, mood disorders and quality of life in a select group of ARDS survivors.
Methods:   A cross-sectional study was conducted to describe the specific impairments in cognitive function, mood and quality of life in a group of 79 self-selected ARDS survivors who contacted an Internet-based support site. A battery of cognitive tests was administered by telephone interview. Standardized scores on cognitive tests were compared with normative values and tested for associations with indices of anxiety, depression and quality of life.
Results:   Cognitive impairment was found in 56% of subjects. Compared with population norms, 24% of subjects had deficiencies in short-term memory ( P  = 0.04) and 29% in executive functioning ( P  = 0.001). Moderate or severe anxiety was present in 48% of the study population, and 34% had moderate or severe depression. Moderate or severe anxiety was present in 61% of subjects with evidence of cognitive impairment as compared with 31% of subjects without. Subjects with cognitive impairment scored worse than subjects without cognitive impairment on most subscales of the SF-36 and the Sickness Impact Profile questionnaire.
Conclusions:   Significant cognitive abnormalities may be present in long-term ARDS survivors, particularly in memory and executive function. Impairments in cognition appear to be associated with significantly increased anxiety and worse quality of life.     

Crystallography of supragingival and subgingival human dental calculus

Selected area electron diffraction of sections and individual crystal fragments of human dental calculus has demonstrated that octacalcium phosphate, hydroxyapatitc and whitlockite form the inorganic part of both supragingival and subgingival denial calculus. However, the major constituents in supragingival calculus arc platelet-shaped crystals of octacalcium phosphate and needle-shaped crystals of hydroxyapatite, while bulk crystals of whitlockite is the predominant component in subgingival calculus. The subgingival samples seemed to be better crystallized than the supragingival ones. The results obtained by the electron optical and X-ray powder investigations are in good agreement.