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排序方式: 共有899条查询结果,搜索用时 15 毫秒
891.
Annemiek E. M. de Vries Zanele Xaba Sehulong R. Moraba Luise Goerlitz Hugo A. Tempelman Kerstin Klipstein-Grobusch Lucas E. Hermans Karine Scheuermaier Walter L. J. M. Devillé Alinda G. Vos 《Tropical medicine & international health : TM & IH》2023,28(5):367-373
Objectives
To document the prevalence of impaired glucose tolerance (IGT) and undiagnosed diabetes mellitus (DM) and to identify factors associated with undiagnosed DM in people living with HIV (PLWH).Methods
Cross-sectional study performed at Ndlovu Medical Center, Limpopo, South Africa including PLWH aged ≥18 years. Between August and November 2017, 356 HIV-positive participants were included. Information was collected on socio-demographics, DM symptoms and risk factors for DM. IGT and DM were diagnosed using random plasma glucose and/or HbA1c. Factors associated with undiagnosed DM were assessed by comparing participants with newly diagnosed DM to participants without DM.Results
IGT was diagnosed in 172 (48.3%) participants. Twenty-nine (8.1%) participants met the definition of DM, of whom 17 (58.6%) were newly diagnosed. Compared to participants without DM, participants with DM were on average 5 years older, were more likely to have a positive family history for DM, were less physically active and had higher systolic blood pressure, body mass index and waist circumference. Factors associated with undiagnosed DM included age ≥45 years (odds ratio [OR] = 3.59) and physical inactivity (OR = 3.17).Conclusions
The prevalence of IGT and DM among PLWH is high and more than half of DM cases were undiagnosed. Regular screening for DM in PLWH is recommended, especially in an ageing population with additional cardiovascular disease risk factors. 相似文献892.
893.
Luise Luib Hermann Kreyenberg Sebastian Michaelis Rupert Handgretinger Markus Mezger 《Pediatric transplantation》2023,27(4):e14483
Background
Since the measurement of measurable residual disease (MRD) is part of clinical routine examination for children affected with acute lymphoblastic leukemia (ALL), continuous efforts are made to improve its method, applicability and accuracy. Whereas quantitative real-time polymerase chain reaction (qPCR) is considered as the gold standard for MRD detection and endowed with international guidelines for implementation and evaluation, these do not yet exist for digital droplet PCR (ddPCR). However, advantages are seen in droplet partitioning for MRD measurement to allow absolute quantification without depending on reference samples.Methods
In this study, 17 MRD targets of nine patients with childhood B-ALL were analyzed with qPCR and ddPCR, respectively. All patients were assigned to high risk group and had hematopoietic stem cell transplantation and CD19 antibody therapy for relapse prevention. Starting with the sequences and guidelines of qPCR and optimizing the protocol for ddPCR, the MRD targets could also be measured precisely with this novel method, using the same primer and probe sets as for qPCR.Results
The already established MRD protocol of qPCR could be transferred to ddPCR and all 17 MRD targets were measured in dilution series reaching comparable Limit of detection levels with both PCR methods.Conclusions
With a given qPCR protocol and some experience in conventional MRD monitoring, it is conceivable to transfer the procedure of MRD measurement to ddPCR technology. Our data is in line with other studies which are summarized and discussed here as well to facilitate the transfer of MRD diagnostics to ddPCR. 相似文献894.
Sarah Luise Osterland Mazda Adli Turgay Saritas Peter Schlattmann Joachim Behr Ronja Müller-Mertel Kai Hoffmann Thomas J. Stamm Tom Bschor Christoph Richter Bruno Steinacher Maria-Christiane Jockers-Scherübl Stephan Köhler Andreas Heinz Roland Ricken Pichit Buspavanich 《Acta psychiatrica Scandinavica》2023,147(3):267-275
Introduction
Lithium augmentation (LA) of antidepressants is a first-line therapy option for treatment-resistant depression (TRD). Nevertheless, it is rarely used in geriatric patients mostly because of the fear of kidney toxicity. The purpose of this study is to investigate estimated glomerular filtration rate (eGFR) changes and number of acute kidney injuries (AKI) using LA in geriatric compared with non-geriatric patients.Methods
In a prospective multicenter cohort study, eGFR changes were measured in 201 patients with unipolar depression (nage≥65years = 29; nage<65years = 172) at baseline and over 2–6 weeks of LA. We used linear mixed models to investigate changes in eGFR upon LA and assessed the number of AKIs, according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.Results
Both age groups showed a significant eGFR decline over the course of treatment with lower eGFR in geriatric patients. The lithium serum level (interpretable as “effect of LA”) had a significant effect on eGFR decline. Both effects (age group and lithium serum level) on eGFR decline did not influence each other, meaning the effect of LA on eGFR decline did not differ between age groups. Two AKIs were observed in the geriatric age group when serum lithium levels exceeded the therapeutic range of >0.8 mmol/L.Conclusion
This is the first study investigating eGFR change and AKI upon LA for TRD in geriatric compared with non-geriatric patients. Our data suggest that LA, as an effective treatment option in geriatric patients, should be closely monitored to avoid AKIs. 相似文献895.
Hanna Bonnekoh Luise Erpenbeck 《Journal der Deutschen Dermatologischen Gesellschaft》2023,21(4):374-380
Neutrophilic dermatoses are a group of clinically heterogeneous diseases characterized by infiltration of neutrophils in the affected tissue. Skin symptoms comprise a spectrum of wheals, papules, plaques, pustules, nodules and ulcerations often in combination with systemic symptoms. Although the pathogenesis of these diseases has not yet been elucidated in depth, broad pathophysiological and clinical overlaps exist with autoinflammatory syndromes. Additionally, recent years have shown the relevance of the signaling pathways of TNF-α, IL-1, IL-12/23 and IL-17 in neutrophilic dermatoses. In this review, we present four selected neutrophilic dermatoses, namely pyoderma gangraenosum, Sweet syndrome, generalized pustular psoriasis and Schnitzler syndrome, discuss pathophysiological aspects and specifically address novel therapeutic options derived from the most recent pathophysiological findings. 相似文献
896.
Luise Kuske Abedalrazag Khalifa Alexander Wibisono Jan Hinrich Bräsen Torsten Witte 《International journal of rheumatic diseases》2023,26(9):1821-1825
Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition that was first recognized as a unique disease entity in the early 2000s. Its diagnosis is based on specific pathologic, serologic, and clinical features, and the exclusion of several differential diagnoses, such antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, emerging evidence suggests that these 2 conditions may overlap in some cases. Here, we report a new case of overlapping IgG4-RD and AAV. The patient was diagnosed with IgG4-RD owing to the presence of periaortitis and IgG4 positive tubulointerstitial nephritis. Myeloperoxidase (MPO)-ANCA positivity, chronic paranasal sinusitis, and glomerulonephritis with granuloma led to a concurrent diagnosis of MPO-ANCA-positive granulomatosis with polyangiitis. Our case supports the hypothesis that diagnoses of IgG4-RD and AAV are not mutually exclusive but can overlap. It can be assumed that an overlap with IgG4-RD typically affects the granulomatous form of AAV, suggesting a common pathophysiological pathway for these 2 conditions. 相似文献
897.
Esther Kissling Francisco Pozo Iván Martínez-Baz Silke Buda Ana-Maria Vilcu Lisa Domegan Clara Mazagatos Frederika Dijkstra Neus Latorre-Margalef Sanja Kurečić Filipović Ausenda Machado Mihaela Lazar Itziar Casado Ralf Dürrwald Sylvie van der Werf Joan O'Donnell Juan Antonio Linares Dopido Adam Meijer Maximilian Riess Vesna Višekruna Vučina Ana Paula Rodrigues Maria Elena Mihai Jesús Castilla Luise Goerlitz Alessandra Falchi Jeff Connell Daniel Castrillejo Mariette Hooiveld Annasara Carnahan Maja Ilić Raquel Guiomar Alina Ivanciuc Marine Maurel Ajibola Omokanye Marta Valenciano I-MOVE study team 《Influenza and other respiratory viruses》2023,17(1):e13069
898.
Julie Bergeron Luise Cederkvist Isabel Fortier Naja Hulvej Rod Per Kragh Andersen Anne-Marie Nybo Andersen 《Paediatric and perinatal epidemiology》2023,37(1):45-56
Background
Preterm birth is one of the most important contributors to neonatal mortality and morbidity. Experiencing stress during pregnancy may increase the risk of adverse birth outcomes, including preterm birth. This association has been observed in previous studies, but differences in measures used limit comparability.Objective
The objective of the study was to investigate the association between two measures of maternal stress during pregnancy, life stress and emotional distress, and gestation duration.Methods
Women recruited in the Danish National Birth Cohort from 1996 to 2002, who provided information on their stress level during pregnancy and expecting a singleton baby, were included in the study. We assessed the associations between the level of life stress and emotional distress in quartiles, both collected at 31 weeks of pregnancy on average, and the rate of giving birth using Cox regression within intervals of the gestational period.Results
A total of 80,991 pregnancies were included. Women reporting moderate or high levels of life stress vs no stress had a higher rate of giving birth earlier within all intervals of gestational age (e.g. high level: 27–33 weeks: hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.04, 1.84; 34–36 weeks: 1.10, 95% CI 0.97, 1.25; 37–38 weeks: 1.21, 95% CI 1.15, 1.28). These associations between life stress and preterm birth were mainly driven by pregnancy worries. For emotional distress, a high level of distress was associated with shorter length of gestation in the preterm (27–33 weeks: 1.38, 95% CI 1.02, 1.86; 34–36 weeks: 1.05, 95% CI 0.91, 1.19) and early term (1.11, 95% CI 1.04, 1.17) intervals.Conclusions
Emotional distress and life stress were shown to be associated with gestational age at birth, with pregnancy-related stress being the single stressor driving the association. This suggests that reverse causality may, at least in parts, explain the earlier findings of stress as a risk factor for preterm birth. 相似文献899.
Thomas Birkner Doreen Siegels Luise Heinrich Eva Haufe Susanne Abraham Annice Heratizadeh Inken Harder Magnus Bell Isabell Fell Margitta Worm Christiane Handrick Isaak Effendy Andrea Asmussen Andreas Kleinheinz Bernhard Homey Michael Sticherling Sung-Hei Hong-Weldemann Matthias Augustin Elke Weisshaar Knut Schäkel Thomas Schaefer Beate Schwarz Franca Wiemers Jens-Joachim Brücher Sven Quist Andreas Wollenberg Tilo Biedermann Konstantin Ertner Ralph von Kiedrowski Thomas Werfel Stephan Weidinger Jochen Schmitt and the TREATgermany Study Group 《Journal der Deutschen Dermatologischen Gesellschaft》2023,21(10):1157-1168