全文获取类型
收费全文 | 911篇 |
免费 | 47篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 34篇 |
妇产科学 | 18篇 |
基础医学 | 124篇 |
口腔科学 | 10篇 |
临床医学 | 49篇 |
内科学 | 268篇 |
皮肤病学 | 14篇 |
神经病学 | 91篇 |
特种医学 | 13篇 |
外科学 | 65篇 |
综合类 | 2篇 |
预防医学 | 74篇 |
眼科学 | 5篇 |
药学 | 48篇 |
中国医学 | 1篇 |
肿瘤学 | 144篇 |
出版年
2024年 | 1篇 |
2023年 | 13篇 |
2022年 | 15篇 |
2021年 | 38篇 |
2020年 | 14篇 |
2019年 | 22篇 |
2018年 | 34篇 |
2017年 | 22篇 |
2016年 | 31篇 |
2015年 | 26篇 |
2014年 | 30篇 |
2013年 | 45篇 |
2012年 | 82篇 |
2011年 | 74篇 |
2010年 | 44篇 |
2009年 | 31篇 |
2008年 | 52篇 |
2007年 | 64篇 |
2006年 | 64篇 |
2005年 | 60篇 |
2004年 | 60篇 |
2003年 | 49篇 |
2002年 | 41篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 8篇 |
1997年 | 4篇 |
1996年 | 6篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1989年 | 3篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有964条查询结果,搜索用时 15 毫秒
961.
Arnon Nagler Vincenzo Maria Perriello Lorenza Falini Brunangelo Falini 《British journal of haematology》2023,201(3):396-410
Chimeric antigen receptor (CAR) T cells targeting CD19 represent a promising salvage immunotherapy for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), offering ~40% of long-term responses. In everyday clinical practice, haematologists involved in CAR T cell treatment of patients with R/R DLBCL have to deal with diagnostically complex cases and difficult therapeutic choices. The availability of novel immunotherapeutic agents for R/R DLBCL and recent advances in understanding CAR T-cell failure mechanisms demand a rational approach to identify the best choice for bridging therapy and managing post-CAR T-cell therapy relapses. Moreover, positron emission tomography/computerised tomography may result in false-positive interpretation, highlighting the importance of post-treatment biopsy. In this review, we discuss all above issues, presenting four instructive cases, with the aim to provide criteria and new perspectives for CAR T-cell treatment of DLBCL. 相似文献
962.
Francesca Romana Ponziani Antonio Nesci Camilla Caputo Lucia Salvatore Anna Picca Federica Del Chierico Francesco Paroni Sterbini Emanuele Marzetti Angela Di Giorgio Luca Santoro Lorenza Putignani Antonio Gasbarrini Angelo Santoliquido Maurizio Pompili 《Liver international》2023,43(2):370-380
Background and Aims
Hypercholesterolemia is frequent in people with primary biliary cholangitis (PBC); however, it does not seem to confer an increased risk of cardiovascular disease. We aimed to evaluate the prevalence of peripheral arterial disease in PBC women and its association with the gut–liver axis and systemic inflammation.Methods
Thirty patients affected by PBC and hypercholesterolemia were enrolled, with equal-sized groups of women with non-alcoholic fatty liver disease (NAFLD) and healthy controls (CTRL). All patients underwent Doppler ultrasound examination of peripheral arteries, assessment of flow-mediated dilation, quantification of circulating cytokines and vasoactive mediators and characterization of the gut microbiota.Results
PBC patients had a higher prevalence of lower extremity arterial disease (LEAD) defined as atherosclerotic plaques in any of femoral, popliteal and/or tibial arteries compared with both NAFLD and CTRL women (83.3% vs. 53.3% and 50%, respectively; p = .01). Factors associated with LEAD at univariate analysis were VCAM-1 (p = .002), ICAM-1 (p = .003), and TNF-alpha (p = .04) serum levels, but only VCAM-1 (OR 1.1, 95% CI 1.0–1.1; p = .04) and TNF-alpha (OR 1.12, 95% CI 0.99–1.26; p = .04) were confirmed as independent predictors in the multivariate model. Gut microbiota analysis revealed that Acidaminococcus (FDR = 0.0008), Bifidobacterium (FDR = 0.001) and Oscillospira (FDR = 0.03) were differentially expressed among groups. Acidaminococcus, which was increased in PBC, was positively correlated with TNF-alpha serum levels. Down-regulation of metabolic pathways linked to fatty acid and butyrate metabolism, glyoxylate metabolism and branched-chain amino acids degradation was found in the functional gut metagenome of PBC women.Conclusions
LEAD is common in patients affected by PBC and is associated with inflammatory markers and alterations in the gut–liver axis. 相似文献963.
Annarita Barone Martina Billeci Sofia D'Amore Michele De Prisco Giuseppe De Simone Eleonora Ermini Vittorio Freda Federica Iannotta Adalgisa Luciani Luca Pistone Lorenza M. Rifici Viviana M. Saia Giancarlo Spennato Francesco Subosco Licia Vellucci Giordano D'Urso Diana Galletta Michele Fornaro Felice Iasevoli Andrea de Bartolomeis 《Journal of community psychology》2023,51(1):154-167
Few longitudinal studies have so far investigated the impact of sustained COVID-19 among people with pre-existing psychiatric disorders. We conducted a prospective study involving people with serious mental illness (n = 114) and healthy controls (n = 41) to assess changes in the Perceived Stress Scale, Generalized Anxiety Disorder Scale, Patient Health Questionnaire, and Specific Psychotic Experiences Questionnaire scores 18 months after the COVID-19 pandemic outset. Subjects underwent interviews with a mental health professional in April 2020 and at the end of the local third wave (October 2021). A significant increase in perceived stress was found in healthy controls, especially females. Psychiatric patients showed a significant worsening of anxiety symptoms compared to baseline records (t = −2.3, p = 0.036). Patients who rejected vaccination had significantly higher paranoia scores compared to those willing to get vaccinated (U = 649.5, z = −2.02, p = 0.04). These findings indicate that COVID-19's sustained emergency may cause enduring consequences on mental health, soliciting further investigations. 相似文献
964.