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931.
Annamaria Altomare Lorenza Putignani Federica Del Chierico Silvia Cocca Silvia Angeletti Massimo Ciccozzi Costanza Tripiciano Bruno Dalla Piccola Michele Cicala Michele Pier Luca Guarino 《Digestive and liver disease》2019,51(5):648-656
BackgroundGrowing evidence supports the potential role of intestinal microbiota in the pathophysiology of inflammatory bowel diseases (IBD) even if the literature does not reveal uniform alterations. The aim of the study was to evaluate the mucosal (MM) and faecal microbiota (FM) composition in a cohort of IBD patients compared to healthy controls (CTRLs).MethodsFaecal and mucosal samples were collected from 14 IBD patients and 11 CTRLs. The V1-V3 region of 16S rRNA locus was amplified on a 454-Junior Genome Sequencer. Reads were grouped into operational taxonomic units (OTUs) at a sequence similarity level of 97% for taxonomic assignment, and aligned for OTUs matching against Greengenes database.ResultsIrrespective of disease localization and activity, in the MM of IBD patients a statistically significant increase of Proteobacteria (especially Enterobacteriaceae, Acidaminococcus, Veillonella dispar) and decrease of Firmicutes (especially Roseburia and Faecalibacterium prausnitzii) and Actinobacteria was found compared to CTRLs. In the colon district some specific bacterial biomarkers were identified: Enterobacteriaceae for IBD stools, Bacteroides for IBD biopsies, Mogibacteriaceae, Ruminococcaceae and Prevotella for CTRL stools, Ruminococcaceae for CTRL biopsies.ConclusionsThe profiles of FM were more similar to CTRLs, suggesting that microbiota adhering to the gut mucosa better discriminates patients from controls, with the identification of some interesting biomarkers. 相似文献
932.
Maura Massimino Lorenza Gandola Salvina Barra Felice Giangaspero Cecilia Casali Paolo Potepan Concezio Di Rocco Paolo Nozza Paola Collini Elisabetta Viscardi Daniele Bertin Veronica Biassoni Armando Cama Claudia Milanaccio Piergiorgio Modena Rita Balter Giampiero Tamburrini Paola Peretta Maurizio Mascarin Giovanni Scarzello Paola Fidani Giuseppe Maria Milano Iacopo Sardi Lorenzo Genitori Maria Luisa Garrè 《International journal of radiation oncology, biology, physics》2011
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934.
Uberto Fumagalli Stefano de Carli Stefano de Pascale Lorenza Rimassa Mario Bignardi Riccardo Rosati 《Updates in surgery》2010,62(1):63-67
Treatment of adrenal metastases from cancer of the esophagogastric junction (EGJ) is not defined. The aim of the present work is to analyze retrospectively our experience in treating patients with adrenal metastases from EGJ adenocarcinoma. 102 patients with Siewert 1 or 2 EGJ adenocarcinoma underwent esophagectomy between May 2001 and Jan 2009. Five patients were diagnosed an adrenal metastases from EGJ adenocarcinoma, synchronous (s) in one and metachronous (m) in four, in the latter 11 months (mean) after esophagectomy. At diagnosis, three patients had synchronous metastases to mediastinal nodes (1 s and 2 m), 1 (m) had synchronous metastases to bone, and 1 (m) had an isolated adrenal metastasis. Three patients with synchronous node metastasis received chemotherapy followed by adrenalectomy 3, 8 and 16 months (mean 9) after diagnosis; one patient also received postoperative mediastinal radiotherapy. These patients are alive with no evidence of disease 16, 40 and 50 months after diagnosis of adrenal metastasis. The patient with bone metastasis received chemotherapy only and died 12 months after diagnosis of metastatic disease. The patient with isolated metastasis underwent laparoscopic adrenalectomy only, developed early bone metastases and died 15 months after surgery. In conclusion, our experience indicates that patients with adrenal metastases from adenocarcinoma of the EGJ may benefit from adrenalectomy if the gland is the only site of metastasis beyond lymphnodal disease. Chemotherapy should be considered before adrenalectomy to achieve better disease control and identify aggressive disease that would contraindicate adrenalectomy. 相似文献
935.
Garazzino S Krzysztofiak A Esposito S Castagnola E Plebani A Galli L Cellini M Lipreri R Scolfaro C Bertaina C Calitri C Bozzola E Lancella L Quondamcarlo A Bosis S Pugni L Losurdo G Soresina A De Gaudio M Mariotti I Mancini L Gabiano C Tovo PA 《The Journal of antimicrobial chemotherapy》2011,66(10):2393-2397
936.
937.
Debette S Metso T Pezzini A Abboud S Metso A Leys D Bersano A Louillet F Caso V Lamy C Medeiros E Samson Y Grond-Ginsbach C Engelter ST Thijs V Beretta S Béjot Y Sessa M Lorenza Muiesan M Amouyel P Castellano M Arveiler D Tatlisumak T Dallongeville J;Cervical Artery Dissection Ischemic Stroke Patients 《Circulation》2011,123(14):1537-1544
938.
939.
Speranza L Franceschelli S D'Orazio N Gaeta R Bucciarelli T Felaco M Grilli A Riccioni G 《Microvascular research》2011,82(3):391-396
Aim
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) which plays an important role in controlling vascular tone and regulates the contractile properties of cardiac myocytes. The aim of this study was to investigate the effect of pharmacological treatment on symmetric dimethylarginine (SDMA), ADMA and arginine plasma concentrations in patients with acute congestive heart failure (ACHF) through the evaluation of type-1 system cationic amino acid transporter-1/type 1 dimethylarginine dimethylaminohydrolases-1 (CAT-1/DDAH-1).Methods and results
25 hospitalized cardiology patients with symptomatic acute congestive HF (NYHA Class III-IV) and impaired left ventricular (LV) function (ejection fraction < 35%) were included in the study. ADMA, SDMA, and arginine plasma concentrations were assessed before and after pharmacological treatment by high performance liquid chromatography. All patients received an adequate pharmacological treatment for ACHF. ADMA and SDMA plasma levels were significantly higher after pharmacological treatment respect to baseline values (pre-treatment) (0.75 vs 0.48; 1.31 vs 1.03; p < 0.01). Arginine plasma concentration was significantly lower after therapy respect to baseline values (0.78 vs 0.99; p < 0.01). This is associated more with the modulation of DDAH-1 protein than with of CAT-1 system transport.Conclusions
In patients with ACHF, acute renal impairment function and the modulation of metabolism and extracellular transport by the DDAH-1/CAT-1 system determine high ADMA and SDMA levels after therapy for acute congestive heart failure. 相似文献940.