Role of Th1/Th2 cells activation in chronic hepatitis B virus infection

Clonal analysis of mndne T cells has led to the idenuncation of Z typeS of Th cells, Thl and on. Thl cells,chacterized by secreting interferon-y (Iap-Y), interleukin-2 (IL2) and tumor necrosis factor-5 (TNF-3), involved Principally in cell-mediated ~ity and play acrucial role in defending the host against intracellularPathogens such as a Vallety of yi~es. ThZ cells,secreting IL4, ms, IL-6 and ilo, mostly regulateh~ immune responSe, and may oafs Paxtial PIDtection against extracellula…     

Human papillomaviruses and papillomatosis lesions of the female lower genital tract

Objective: The objective of this study was to determine whether human papillomavirus (HPV) infections are involved in the development of papillomatosis lesions of the lower female genital tract.Methods: A total of 616 biopsy specimens of genital papillomatous lesions (307 nodular and 309 papular types) from 598 patients were anaylyzed for the presence of HPV DNA sequences by polymerase chain reaction (PCR). These specimens were also examined by histopathological assessment for characteristic HPV-associated cytological changes, by immunohistochemical staining for HPV-associated antigen, and by electron microscopy for the presence of virions.Results: HPV DNA sequences were found in 97.9% (140 of 143 cases) and 1.1% (1 of 91 cases) of the nodular and papular papillomatosis cases tested, respectively. In 18 patients who had both types of papillomatosis lesions, HPV DNA was invariably found only in nodular tissues. HPV-associated antigen, koilocytosis, and virions were found in 53.6% (98 of 183 cases), 70.5% (129 of 183 cases), and 5.9% (5 of 85 cases) of nodular papillomatosis lesions tested, respectively.Conclusions: These data suggest that nodular papillomatosis was closely associated with HPV infection, but that papular papillomatosis of the lower female genital tract may have an etiology other than HPV infection.     

急性非淋巴细胞白血病中MGMT与p53基因突变的研究

目的 探讨肿瘤抑制基因ｐ５３、ＭＧＭＴ在急性非淋巴细胞白血病（ＡＮＬＬ）中的改变。方法 用聚合酶链反应－单链构象多态性（ＰＣＲ－ＳＳＣＰ）技术对３１例ＡＮＬＬ患者、２２例正常人ｐ５３基因第５、６、７、８外显子和ＭＧＭＴ基因第１、４外显子进行突变分析。结果 ３１例ＡＮＬＬ中５例存在ｐ５３基因突变、４例存在ＭＧＭＴ基因突变,其中２例ｐ５３与ＭＧＭＴ同时发生突变。结论 ｐ５３基因突变在白血病发生中起一定     

Unilateral comminuted and complicated fracture of the mandible due to dog attack

Fractures of the mandible and their management are discussed in detail in textbooks and articles dealing with facial trauma. This paper presents the management and treatment of a case of a unilateral comminuted and complicated fracture of the mandible due to dog attack on a geriatric patient. The attack also severed the patient's right arm. Due to the severity of the trauma, an emergency surgery was performed on the mandible and arm.     

THE CHARACTERISTICS OF OVARIAN SEROUS TUMORS OF BORDERLINE MALIGNANCY

During 1948-1976, 363 cases of ovarian serous tumor were encountered in the hospital. Among them, 58 cases were pathologically compatible with the criteria of this tumor of borderline ma- lignancy proposed by the WHO classification. The purp8se of this paper is threefold: 1. To study the c!inical behavior and mode of de- velopment of pathologically documented bordcr- line malignant serous ovarian tumors. 2. To compare the difference between benign, border- line malignant and malignant serous tumors. 3. To assess the value of making such a "borderline malignant" subgroup.     

农村妇女避孕方法使用及其影响因素分析

本文使用的数据来源于1986年在江苏省进行的“农村已婚育龄妇女使用避孕方法的变异”的调查。本次调查的目的是对已婚育龄妇女避孕方法使用的类型及动力学进行综合研究。调查的数据表明,江苏农村已婚育龄妇女的避孕率为85%,其中,宫内节育器和女性绝育术为最普遍使用的方法。在使用避孕方法的妇女中,宫内节育器和女性绝育术的使用比例分别为46.6%和36.4%。妇女对正在使用的避孕方法的评价和希望使用新方法的意愿都存在着差别。从这些差别的分析中不难看出,面对广大育龄妇女的避孕要求,我们应提供较为先进的避孕方法的信息及咨询服务,从而扩大避孕方法的可选择范围,避免一些方法的错误使用,提高使用者的满意程度。     

慢性硬膜下血肿20例临床分析

目的 分析慢性硬膜下血肿(CSDH)的临床特征。方法 收集20例CSDH，就其临床表现、发病机制及防治和预后进行临床探讨。结果 CSDH临床症状不典型，尤其是老年人，初诊误诊率达50％，积极治疗治愈率达100％。结论 应重视CSDH的早期诊断。