全文获取类型
收费全文 | 600605篇 |
免费 | 41229篇 |
国内免费 | 29472篇 |
专业分类
耳鼻咽喉 | 4612篇 |
儿科学 | 12023篇 |
妇产科学 | 8093篇 |
基础医学 | 64451篇 |
口腔科学 | 8770篇 |
临床医学 | 72579篇 |
内科学 | 88296篇 |
皮肤病学 | 5572篇 |
神经病学 | 37114篇 |
特种医学 | 24861篇 |
外国民族医学 | 264篇 |
外科学 | 67154篇 |
综合类 | 79745篇 |
现状与发展 | 102篇 |
一般理论 | 52篇 |
预防医学 | 48191篇 |
眼科学 | 15540篇 |
药学 | 55705篇 |
476篇 | |
中国医学 | 27913篇 |
肿瘤学 | 49793篇 |
出版年
2024年 | 1102篇 |
2023年 | 5576篇 |
2022年 | 14114篇 |
2021年 | 20784篇 |
2020年 | 16177篇 |
2019年 | 13585篇 |
2018年 | 34879篇 |
2017年 | 29884篇 |
2016年 | 31169篇 |
2015年 | 20232篇 |
2014年 | 25082篇 |
2013年 | 22840篇 |
2012年 | 39522篇 |
2011年 | 56836篇 |
2010年 | 42618篇 |
2009年 | 30945篇 |
2008年 | 43560篇 |
2007年 | 45550篇 |
2006年 | 23986篇 |
2005年 | 24620篇 |
2004年 | 18179篇 |
2003年 | 18507篇 |
2002年 | 14130篇 |
2001年 | 10334篇 |
2000年 | 10212篇 |
1999年 | 10270篇 |
1998年 | 6521篇 |
1997年 | 6323篇 |
1996年 | 4851篇 |
1995年 | 4564篇 |
1994年 | 3878篇 |
1993年 | 2503篇 |
1992年 | 2978篇 |
1991年 | 2654篇 |
1990年 | 2328篇 |
1989年 | 2001篇 |
1988年 | 1670篇 |
1987年 | 1426篇 |
1986年 | 1169篇 |
1985年 | 891篇 |
1984年 | 503篇 |
1983年 | 368篇 |
1982年 | 205篇 |
1981年 | 215篇 |
1980年 | 182篇 |
1979年 | 217篇 |
1978年 | 103篇 |
1977年 | 68篇 |
1974年 | 88篇 |
1938年 | 62篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
31.
目的:探讨中西医结合治疗对单纯疱疹病毒性角膜炎(HSK)患者视力恢复及血清微量元素的影响。方法:选取2015年1月至2016年10月内蒙古包钢医院收治的HSK患者86例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组43例。对照组采用更昔洛韦滴眼液及硫酸软骨素滴眼液治疗,观察组在对照组基础上结合清肝明目汤进行治疗,2组均连续治疗4周。比较2组患者临床疗效;比较治疗前后2组患者视力恢复状况、血清微量元素及泪液免疫因子水平。结果:治疗后,观察组治疗有效率显著高于对照组,差异有统计学意义(P0.05);治疗后观察组患者视觉模拟评分及视力均显著高于治疗前与对照组,差异有统计学意义(P0.05);治疗后观察组铁离子、钙离子及铜离子水平低于治疗前与对照组,差异有统计学意义(P0.05);血清锌离子水平明显高于治疗前与对照组(P0.05),差异有统计学意义(P0.05);治疗后观察组患者泪液IgA、IgG及C3水平明显高于治疗前与对照组,差异有统计学意义(P0.05)。结论:中西医结合治疗HSK有效促进患者视力的恢复,调节血清微量元素的同时增强患者泪液免疫因子水平,疗效显著优于单用西药治疗。 相似文献
32.
Xiying Fan Glen A. Bjerke Kent Riemondy Li Wang Rui Yi 《Molecular carcinogenesis》2019,58(12):2241-2253
MicroRNAs (miRNAs) play important roles in prostate cancer development. However, it remains unclear how individual miRNAs contribute to the initiation and progression of prostate cancer. Here we show that a basal layer‐enriched miRNA is required for prostate tumorigenesis. We identify miR‐205 as the most highly expressed miRNA and enriched in the basal cells of the prostate. Although miR‐205 is not required for normal prostate development and homeostasis, genetic deletion of miR‐205 in a Pten null tumor model significantly compromises tumor progression and does not promote metastasis. In Pten null basal cells, loss of miR‐205 attenuates pAkt levels and promotes cellular senescence. Furthermore, although overexpression of miR‐205 in prostate cancer cells with luminal phenotypes inhibits cell growth in both human and mouse, miR‐205 has a minimal effect on the growth of a normal human prostate cell line. Taken together, we have provided genetic evidence for a requirement of miR‐205 in the progression of Pten null‐induced prostate cancer. 相似文献
33.
Effects of the Clearing the Lung and Dissipating Phlegm Method in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
下载免费PDF全文
![点击此处可从《World Journal of Traditional Chinese Medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tao Zhang Yao-Hui Li Gai-Xia Liu Xiu-Lin Tang 《World Journal of Traditional Chinese Medicine》2019,(1)
Objective: The objective of this study is to evaluate the efficacy and safety of the clearing the lung and dissipating phlegm method in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD) and to provide evidence for the treatment of the disease. Materials and Methods: Literature was searched from the United States National Library of Medicine(PubMed), Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database(Wanfang), and the Full?Text Database of Chinese Scientific and Technical Periodicals(VIP).A comprehensive collection was made of randomized controlled trials(RCTs) before June 2018, in which the treatment groups used either the clearing the lung and dissipating phlegm formulas only or combined it with routine Western medicine therapy, and the control group adopted routine Western medicine therapy only for the acute exacerbation of COPD. The Cochrane risk of bias method was used to evaluate the quality of the literature. The data were analyzed and retrieved independently by two reviewers before meta?analysis was carried out with RevMan 5.3 software to evaluate the primary outcome measures, including the total clinical effective rate, and the secondary outcome measures such as the pulmonary function(forced vital capacity [FVC], forced expiratory volume in the 1 s [FEV1], percentage of FEV1 [FEV1%], and FEV1/FVC)and blood gases(PaO_2 and PaCo_2). Results: A total of 13 RCTs involving 990 patients(496 in the treatment group and 494 in the control group)were included in this study. Meta?analysis revealed significant difference in the efficacy of the group that adopted solely the routine Western medicine method and the group that combined the Western medicine with the clearing the lung and dissipating phlegm method. Outcome measures including the pulmonary function(FVC, FEV1, FEV1%, and FEV1/FVC) and the blood gases(PaO_2 and PaCo_2) were significantly improved as compared to the control group(P 0.00001). However, adverse effects in the treatment group using combined traditional Chinese medicine were not reported due to the short observation time of the study. Conclusion: The clearing the lung and dissipating phlegm method can improve the efficacy in the treatment of acute exacerbation of COPD, the outcome measures of the pulmonary function and the blood gases,as well as the life quality of the patients. However, due to the fact that the existing studies are generally of poor quality in which randomization and its implementation were not properly carried out, more high?quality RCTs are necessary to confirm the findings of this study. 相似文献
34.
患者男,74岁,主因尿频、尿急、排尿困难10余年,加重1个月,患者因脑梗死后遗症康复治疗于2018年8月1日就诊于天津中医药大学第一附属医院针灸科。查颅脑MR:未见新发梗死灶。患者10余年前发现尿频、尿急、尿不尽、夜尿多等症状,曾诊断“良性前列腺增生”,未经系统诊治。 相似文献
36.
37.
良性前列腺增生(BPH)是老年男性常见的泌尿系统疾病,其发病与前列腺慢性炎症之间存在显著相关。感染因子、尿液返流、代谢综合征、衰老过程和自身免疫应答在内的几种刺激,通过相应分子途径引起前列腺免疫细胞的组织定位和组成成分发生广泛改变,从而导致免疫系统失调,之后引发的组织损伤和缓慢愈合,导致了BPH发生和进展。本文通过总结良性前列腺增生与前列腺慢性炎症的相关性的临床研究结果,前列腺免疫细胞在病理生理机制层面与前两者之间的内在联系,以及抗炎药物对BPH-LUTS的干预作用,以其为BPH-LUTS的药物研发提供参考。 相似文献
38.
39.
目的:观察应力刺激结合温经活血汤治疗骨折延迟愈合的临床疗效。方法:40例随机分成两组各20例,两组均行应力刺激。治疗组给予温经活血汤治疗、对照组给予接骨七厘片治疗。结果:治疗4周、8周两组血清ALP、BGP指标比较差异有统计学意义(P<0.05),治疗4周、8周和治疗结束后4周骨痂评分两组比较差异均有统计学意义(P<0.05),总体疗效治疗组优于对照组(P<0.05)。结论:应力刺激结合温经活血汤治疗骨折延迟愈合疗效较好。 相似文献
40.