全文获取类型
收费全文 | 2354篇 |
免费 | 161篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 72篇 |
妇产科学 | 47篇 |
基础医学 | 387篇 |
口腔科学 | 133篇 |
临床医学 | 160篇 |
内科学 | 579篇 |
皮肤病学 | 79篇 |
神经病学 | 139篇 |
特种医学 | 26篇 |
外科学 | 216篇 |
综合类 | 20篇 |
一般理论 | 6篇 |
预防医学 | 269篇 |
眼科学 | 26篇 |
药学 | 178篇 |
中国医学 | 2篇 |
肿瘤学 | 172篇 |
出版年
2023年 | 28篇 |
2022年 | 65篇 |
2021年 | 95篇 |
2020年 | 51篇 |
2019年 | 87篇 |
2018年 | 82篇 |
2017年 | 60篇 |
2016年 | 66篇 |
2015年 | 97篇 |
2014年 | 86篇 |
2013年 | 124篇 |
2012年 | 217篇 |
2011年 | 225篇 |
2010年 | 100篇 |
2009年 | 75篇 |
2008年 | 122篇 |
2007年 | 143篇 |
2006年 | 129篇 |
2005年 | 126篇 |
2004年 | 103篇 |
2003年 | 90篇 |
2002年 | 113篇 |
2001年 | 30篇 |
2000年 | 27篇 |
1999年 | 40篇 |
1998年 | 19篇 |
1997年 | 17篇 |
1996年 | 11篇 |
1995年 | 8篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 8篇 |
1991年 | 9篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1975年 | 5篇 |
1974年 | 2篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1968年 | 5篇 |
排序方式: 共有2530条查询结果,搜索用时 15 毫秒
61.
62.
Sara García‐Jiménez German Bernal Fernández Maria Fernanda Martínez Salazar Antonio Monroy Noyola Cairo Toledano Jaimes Angelica Meneses Acosta Leticia Gonzalez Maya Elizabeth Aveleyra Ojeda Maria A. Terrazas Meraz Boll Marie‐Catherine Miguel A. Sánchez‐Alemán 《Journal of clinical laboratory analysis》2015,29(1):5-9
63.
64.
Emi Sasagawa Hirotsugu Aiga Edith Yanira Corado Soriano Blanca Leticia Cuyuch Marroquín Marta Alicia Hernández Ramírez Ana Vilma Guevara de Aguilar José Eduardo Romero Chévez Hector Manuel Ramos Hernández Rafael Antonio Cedillos Chizuru Misago Kiyoshi Kita 《The American journal of tropical medicine and hygiene》2015,93(2):326-333
To estimate the incidence (any mother to child) and rate (from seropositive mother to child) of mother-to-child transmission of Trypanosoma cruzi, a serological census was conducted, targeting pregnant women and infants born to seropositive mothers, in four municipalities of El Salvador. Of 943 pregnant women, 36 (3.8%) were seropositive for T. cruzi. Of 36, 32 proceeded to serological tests of their infants when they became 6–8 months of age. Six infants seropositive at the age of 6–8 months further proceeded to second-stage serological test at the age of 9–16 months. As the result, one infant was congenitally infected. Thus, serological tests at the age of 6–8 months produced five false positives. To ensure earlier effective medication only for true positives, identification of seropositive infants at the age of 9–16 months is crucial. Incidence and rate of mother-to-child transmission were 0.14 (per 100 person-years) and 4.0%, respectively. Estimated number of children infected through mother-to-child transmission in El Salvador (170 per year) was much higher than that of human immunodeficiency virus (HIV; seven per year). It is recommended that serological testing for T. cruzi be integrated into those for HIV and syphilis as part of antenatal care package. 相似文献
65.
66.
67.
Daniella Alejandra Pompa-Monroy Paulina Guadalupe Figueroa-Marchant Syed G. Dastager Meghana Namdeo Thorat Ana Leticia Iglesias Valentín Miranda-Soto Graciela Lizeth Prez-Gonzlez Luis Jesús Villarreal-Gmez 《Materials》2020,13(23)
Electrospun nanofibers are used for many applications due to their large surface area, mechanical properties, and bioactivity. Bacterial biofilms are the cause of numerous problems in biomedical devices and in the food industry. On the other hand, these bacterial biofilms can produce interesting metabolites. Hence, the objective of this study is to evaluate the efficiency of poly (Ɛ- caprolactone)/Curcumin (PCL/CUR) nanofibers to promote bacterial biofilm formation. These scaffolds were characterized by scanning electron microscopy (SEM), which showed homogeneous fibers with diameters between 441–557 nm; thermogravimetric analysis and differential scanning calorimetry (TGA and DSC) demonstrated high temperature resilience with degradation temperatures over >350 °C; FTIR and 1H-NMR serve as evidence of CUR incorporation in the PCL fibers. PCL/CUR scaffolds successfully promoted the formation of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa biofilms. These results will be valuable in the study of controlled harvesting of pathogenic biofilms as well as in metabolites production for biotechnological purposes. 相似文献
68.
Merino Almazán Macarena Duarte Pérez Juan Manuel Marín Pozo Juan Francisco Ortega Granados Ana Laura Muros De Fuentes Begoña Quesada Sanz Paz Gago Sánchez Ana Isabel Rodríguez Gómez Patricia Jurado García José Miguel Artime Rodríguez-Hermida Fátima Martínez Bautista María José Rueda Ramos Antonio Mora Rodríguez Beatriz Martínez Díaz María Carmen Nieto Guindo Pablo Garrido Siles Margarita Villatoro Roldán Rosa Roldán Morales José Carlos Artacho Criado Silvia María Baños Roldán Úrsula Inoriza Rueda Ángel Garrido Martínez María Teresa 《International journal of clinical pharmacy》2019,41(1):272-279
International Journal of Clinical Pharmacy - Background Immunotherapy has become a standard treatment for lung cancer; however, the high cost makes it necessary to assess health outcomes. Objective... 相似文献
69.
Angélica Flores-Flores Samuel Estrada-Soto César Millán-Pacheco Blanca Bazán-Perkins Rafael Villalobos-Molina Leticia Moreno-Fierros Rogelio Hernández-Pando Sara García-Jiménez Julio César Rivera-Leyva 《Drug development research》2019,80(2):218-229
Previously, we described tracheal rat rings relaxation by several flavonoids, being 6-hydroxyflavone (6-HOF) the most active derivative of the series. Thus, its mechanism of action was determined in an ex vivo tracheal rat ring bioassay. The anti-asthmatic effect was assayed in in vivo OVAlbumin (OVA)-sensitized guinea pigs. Finally, the toxicological profile of 6-HOF was studied based on Organization of Economic Cooperation and Development guidelines with modifications. 6-HOF–induced relaxation appears to be related with receptor-operated calcium channel and voltage-operated calcium channel blockade as the main mechanism of action, and also through the production of relaxant second messengers NO and cGMP. Molecular docking supports that 6-HOF acts as calcium channel blocker and by activation of nitric oxide synthase. In addition, the in vivo anti-asthmatic experiments demonstrate the dose-dependent significant anti-allergic effect of 6-HOF induced by OVA, with best activity at 50 /kg. Finally, toxicological studies determined a LD50 > 2,000 mg/kg and, after 28 day of treatment with 6-HOF (50 mg/kg) by intragastric route, mice did not exhibit evidence of any significant toxicity. In conclusion, experiments showed that 6-HOF exerts significant relaxant activity through calcium channel blockade, and possibly, by NO/cGMP-system stimulation on rat trachea, which interferes with the contraction mechanism of smooth muscle cells in the airways. In addition, the flavonoid shows potential anti-asthmatic properties in an anti-allergic pathway. Furthermore, because the pharmacological and safety evidence, we propose this flavonoid as lead for the development of a novel therapeutic agent for the treatment of asthma and related respiratory diseases. 相似文献
70.
Ultralarge von Willebrand factor (ULVWF) multimeric strings are rapidly secreted by, and anchored to, stimulated endothelial cells (EC), and are hyperadhesive to platelets until cleavage by ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). In ADAMTS-13-deficient familial and autoantibody-mediated thrombotic thrombocytopenic purpura (TTP), there is severely restricted cleavage of EC-anchored ULVWF-platelet strings. The small amount of active enzyme released from their EC cleaves ULVWF strings minimally just above EC surfaces, thus generating soluble ULVWF multimers that are 2.5 to 50 times longer than plasma von Willebrand factor (VWF) forms. Soluble ULVWF multimers (detected in TTP and several other disorders) are also hyperadhesive to platelets and can cause excessive platelet adhesion/aggregation. Without exogenous chemicals or extreme shear stress, soluble ULVWF multimers cannot be cleaved by ADAMTS-13 but can be de-assembled (reduced) in vitro, by a free thiol-containing molecule (>30 kD) present in the cryosupernatant fraction of plasma that is not ADAMTS-13, thrombospondin-1, albumin, cysteine, or glutathione. This reduction may prevent occlusion of the microvasculature by embolic soluble ULVWF multimers (± adherent/aggregated platelets). New inhibitors of platelet adhesion to EC-anchored ULVWF multimeric strings and soluble ULVWF include an aptamer, a nanobody, and N-acetylcysteine. 相似文献