全文获取类型
收费全文 | 9219篇 |
免费 | 383篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 307篇 |
儿科学 | 213篇 |
妇产科学 | 466篇 |
基础医学 | 1237篇 |
口腔科学 | 94篇 |
临床医学 | 687篇 |
内科学 | 2022篇 |
皮肤病学 | 234篇 |
神经病学 | 618篇 |
特种医学 | 199篇 |
外科学 | 1249篇 |
综合类 | 125篇 |
一般理论 | 1篇 |
预防医学 | 456篇 |
眼科学 | 162篇 |
药学 | 927篇 |
中国医学 | 41篇 |
肿瘤学 | 648篇 |
出版年
2023年 | 51篇 |
2022年 | 162篇 |
2021年 | 300篇 |
2020年 | 124篇 |
2019年 | 177篇 |
2018年 | 244篇 |
2017年 | 196篇 |
2016年 | 231篇 |
2015年 | 287篇 |
2014年 | 361篇 |
2013年 | 426篇 |
2012年 | 660篇 |
2011年 | 751篇 |
2010年 | 378篇 |
2009年 | 238篇 |
2008年 | 521篇 |
2007年 | 636篇 |
2006年 | 597篇 |
2005年 | 555篇 |
2004年 | 514篇 |
2003年 | 518篇 |
2002年 | 398篇 |
2001年 | 175篇 |
2000年 | 167篇 |
1999年 | 144篇 |
1998年 | 62篇 |
1997年 | 50篇 |
1996年 | 45篇 |
1995年 | 38篇 |
1994年 | 28篇 |
1993年 | 31篇 |
1992年 | 42篇 |
1991年 | 41篇 |
1990年 | 44篇 |
1989年 | 44篇 |
1988年 | 24篇 |
1987年 | 26篇 |
1986年 | 28篇 |
1985年 | 36篇 |
1984年 | 27篇 |
1983年 | 20篇 |
1982年 | 16篇 |
1979年 | 21篇 |
1978年 | 25篇 |
1977年 | 18篇 |
1976年 | 16篇 |
1975年 | 18篇 |
1974年 | 20篇 |
1972年 | 19篇 |
1966年 | 18篇 |
排序方式: 共有9686条查询结果,搜索用时 0 毫秒
31.
Dunphy CH Galambos C Polski JM Evans HL Gardner LJ Grosso LE Montone KT 《Archives of pathology & laboratory medicine》2002,126(3):351-356
Posttransplant lymphoproliferative disorders (PTLDs) represent a morphologic, immunophenotypic, and genotypic spectrum of disease. Most recently, Knowles et al divided PTLDs into 3 distinct categories: (1) plasmacytic hyperplasia, (2) polymorphic B-cell hyperplasia and polymorphic B-cell lymphoma, and (3) immunoblastic lymphoma and multiple myeloma. Although one form of PTLD may progress to another form, only 1 previous case has been reported in which multiple myeloma developed 14 months after an original diagnosis of plasmacytic hyperplasia. The type of solid organ transplant was not specified in that case. We report a post--cardiac transplant plasmacytic hyperplasia developing 7 years posttransplant. Six years subsequent to the plasmacytic hyperplasia, the patient developed a posttransplant plasmacytic malignancy, supported by morphology, flow cytometric immunophenotyping, and genotypic studies. Since we have no data to support disseminated bony disease or an abnormal serum protein, we have not used the term "multiple myeloma" for this case. 相似文献
32.
33.
P Ku?nierczyk M Wysocka P Kisielow C Radzikowski 《Archivum immunologiae et therapiae experimentalis》1978,26(1-6):111-116
Lyt phenotype of in vitro generated alloreactive cytotoxic T lymphocytes (CTL) and their precursors in B6-Lyt-1.1 (Thy-1.2, Lyt-1.1, Lyt-2.2) congenic strain of mice was studied. The generation of CTL in vitro was completely abrogated by pretreatment of responder cells with antisera to Thy-1.2, Lyt-1.1 and Lyt-2.2 antigens and complement. Mixing of anti-Lyt-1.1-pretreated cells with anti-Lyt-2.2-pretreated cells did not restore CTL generation indicating that both Lyt antigens are expressed on the same precursor cell population. The effect of anti-Lyt sera was specific because the generation of CTL was prevented only when cells from strains possessing appropriate Lyt alleles were pretreated. CTL were eliminated by lysis with anti-Thy-1.2 serum and strongly reduced by anti-Lyt-1.1 and anti-Lyt. 2.2 sera. Nevertheless, a small but significant proportion of CTL was insensitive to lysis with anti-Lyt sera. These data indicate that a phenotype of precursor cells and of majority of CTL is Thy-1.2+ Lyt-1.1+ Lyt-2.2+. 相似文献
34.
Sunlian Feng Karin Ku Emir Hodzic Edward Lorenzana Kim Freet Stephen W. Barthold 《Clinical and Vaccine Immunology : CVI》2005,12(4):531-536
Several species of helicobacter have been isolated from laboratory mice, including H. bilis, H. hepaticus, H. muridarum, H. rodentium, and H. typhlonius, which appear to be the most common. The most widely used published method for molecular detection of these agents is PCR amplification of a conserved region of 16S rRNA, but differential speciation requires restriction enzyme digestion of the amplicons. This study was undertaken to determine PCR conditions that would simultaneously and specifically identify each of the five common species without restriction enzyme analyses. First, we designed novel and specific PCR primers for H. bilis, H. hepaticus, H. muridarum, H. rodentium, and H. typhlonius, using sequences from the heterologous regions of 16S rRNA. Because of comigration of amplified products, we next identified P17, an H. bilis-specific protein; P25, an H. hepaticus-specific protein; and P30, an H. muridarum-specific protein by screening genomic DNA expression libraries of each species. Primers were designed from these three genes, plus newly designed, species-specific 16S rRNA primers for H. rodentium and H. typhlonius that could be utilized for a five-plex PCR. The sizes of the amplicons from H. bilis, H. hepaticus, H. muridarum, H. rodentium, and H. typhlonius were 435, 705, 807, 191, and 122 bp, respectively, allowing simultaneous detection and effective discrimination among species. 相似文献
35.
Łuszczek W Kubicka W Cislo M Nockowski P Mańczak M Woszczek G Baran E Kuśnierczyk P 《Immunology letters》2003,85(1):59-64
Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations. It has not yet been studied in Polish patients at DNA level, but only by serology that is inadequate for HLA-C. Therefore, we examined the distribution of HLA-C alleles by means of low resolution PCR-SSP in 102 Polish psoriatics and 123 healthy controls. We have found significantly higher representation of HLA-Cw*06 (odds ratio, 18.73; P(cor)<0.001) and significantly lower representation of HLA-Cw*07 (odds ratio, 0.41; P(cor)<0.038) in patients than in controls. Association of HLA-Cw*06 with psoriasis was even stronger in early age at onset (0-20 years) group: odds ratio, 77.71; P(cor)<0.001. Therefore, our population seems to belong to those with strong association of psoriasis with HLA-Cw*06. 相似文献
36.
37.
Human heat shock protein 60 (409-424) fragment is recognized by serum antibodies of patients with acute coronary syndromes. 总被引:7,自引:0,他引:7
Jan Wysocki Bozena Karawajczyk Jacek Górski Artur Korzeniowski Zbigniew Ma?kiewicz Gotfryd Kupryszewski Renata Glo?nicka 《Cardiovascular pathology》2002,11(4):238-243
Acute coronary syndromes (ACS), including unstable angina (UA) and acute myocardial infarction (MI), are clinical manifestations of a progressive atherosclerotic process. Antibodies (Ab) to heat shock proteins (hsp) have been reported to be associated with atherosclerosis. Blood samples from 35 patients with ACS and 20 healthy volunteers were tested for Ab to human hsp60 by an enzyme-linked immunosorbent assay (ELISA). Levels of specific serum Ab against hsp60 were significantly elevated in patients with ACS when compared to clinically healthy subjects. To determine the antigenic determinants recognized by these Ab, antibody binding to seven peptides, selected from the hydrophilic and acrophilic regions of the human hsp60 molecule, was assessed. Despite the individual variation in the immune response among patients, one immunodominant region was revealed corresponding to the hsp60 (409-424) peptide. The identification of this epitope may be important for understanding the function of this protein in the atherosclerotic process. 相似文献
38.
Spatial adjacency of stimulus source and response site has been proven important for learning of simple behavioural tasks, including auditory quality and location discrimination. We investigated effect of sound source position (adjacent or not adjacent to manipulanda) on learning and performance of a complex auditory recognition memory task. Spatial adjacency of stimuli and manipulanda improved learning of a simple auditory directional task, which was an intermediate stage of training. In contrast, no improvement of learning and performance of the recognition task was found. 相似文献
39.
40.
Remiszewski P Langfort R Podsiadło B Kuś J Płodziszewska M Radzikowska E Roszkowska B Szopiński J Tomkowski W Wawrzyńska L Wiatr E Wierzbicka M Załeska J Załeska M Zych J Rowińska-Zakrzewska E 《Pneumonologia i alergologia polska》2002,70(5-6):251-257
The aim of this paper is an analysis of clinical documentation and results of autopsy of 21 patients (pts) who died of invasive aspergillosis (IA) in the Institute of Tuberculosis and Chest Diseases in years 1993-2000 and the assessment of predisposing factors for IA. In 17 pts IA was the main and in other 4 only an accessory cause of death. All pts were treated with corticosteroids and/or cytostatic drugs--because of lung cancer (11 pts), cancer in other site (2 pts), haematologic disorders (2 pts), Wegener's granulomatosis (1 pt), polymyositis (1 pt), idiopathic pulmonary fibrosis (1 pt) and other diseases (3 pts). In 15 out of 21 pts granulocytopenia was revealed (from 0.008 x 10(9)/L to 0.82 x 10(9)/L) on an average one month before death. In 15 pts IA was limited to the lungs, in 6 others there were also fungal lesions in brain, kidneys, liver, spleen and heart. Pts with disseminated form of IA had significantly lower granulocyte count and were treated with higher doses of corticosteroids than others. Immunosuppressive drugs and granulocytopenia can be regarded as predisposing factors. Fatal course of IA depended also on the late diagnosis. 相似文献