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101.
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The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
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Salvatore Piano Virendra Singh Paolo Caraceni Rakhi Maiwall Carlo Alessandria Javier Fernandez Elza Cotrim Soares Dong Joon Kim Sung Eun Kim Monica Marino Julio Vorobioff Rita de Cassia Ribeiro Barea Manuela Merli Laure Elkrief Victor Vargas Aleksander Krag Shivaram Prasad Singh Laurentius Adrianto Lesmana Giacomo Zaccherini 《Gastroenterology》2019,156(5):1368-1380.e10
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Mads Egerod Israelsen Lise Lotte Gluud Aleksander Krag 《Journal of gastroenterology and hepatology》2015,30(2):236-243
Cirrhosis is the eighth leading cause of “years of lost life” in the United States and accounts for approximately 1% to 2% of all deaths in Europe. Patients with cirrhosis have a high risk of developing acute kidney injury. The clinical characteristics of hepatorenal syndrome (HRS) are similar to prerenal uremia, but the condition does not respond to volume expansion. HRS type 1 is rapidly progressive whereas HRS type 2 has a slower course often associated with refractory ascites. A number of factors can precipitate HRS such as infections, alcoholic hepatitis, and bleeding. The monitoring, prevention, early detection, and treatment of HRS are essential. This paper reviews the value of early evaluation of renal function based on two new sets of diagnostic criteria. Interventions for HRS type 1 include terlipressin combined with albumin. In HRS type 2, transjugular intrahepatic portosystemic shunt (TIPS) should be considered. For both types of HRS patients should be evaluated for liver transplantation. 相似文献
106.
Predictors of gastrointestinal bleeding in adult ICU patients: a systematic review and meta-analysis
Granholm Anders Zeng Linan Dionne Joanna Colleen Perner Anders Marker Søren Krag Mette MacLaren Robert Ye Zhikang Møller Morten Hylander Alhazzani Waleed 《Intensive care medicine》2019,45(10):1347-1359
Intensive Care Medicine - To systematically identify predictors of gastrointestinal (GI) bleeding in adult intensive care unit (ICU) patients. We conducted a systematic review and meta-analysis of... 相似文献
107.
Krag MB Nielsen S Guo Z Pedersen SB Schmitz O Christiansen JS Jørgensen JO 《Clinical endocrinology》2008,69(3):452-461
Context Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists such as thiazolidinediones (TZDs) improve insulin sensitivity in type 2 diabetes mellitus (T2DM) through effects on fat metabolism whereas GH stimulates lipolysis and induces insulin resistance.
Objective To evaluate the impact of TZDs on fat metabolism and insulin sensitivity in subjects exposed to stable GH levels.
Design A randomized, placebo-controlled, double-blind parallel-group study including 20 GH-deficient patients on continued GH replacement therapy. The patients were studied before and after 12 weeks.
Intervention Patients received either pioglitazone 30 mg ( N = 10) or placebo ( N = 10) once daily for 12 weeks.
Results Adiponectin levels almost doubled during pioglitazone treatment ( P = 0·0001). Pioglitazone significantly decreased basal free fatty acid (FFA) levels ( P = 0·02) and lipid oxidation ( P = 0·02). Basal glucose oxidation rate ( P = 0·004) and insulin sensitivity ( P = 0·03) improved in the patients who received pioglitazone treatment. The change in insulin-stimulated adiponectin level after pioglitazone treatment was positively correlated to the change in insulin-stimulated total glucose disposal ( R = 0·69, P = 0·04).
Conclusion The impact of GH on lipolysis and insulin sensitivity can be modified by administration of TZDs. 相似文献
Objective To evaluate the impact of TZDs on fat metabolism and insulin sensitivity in subjects exposed to stable GH levels.
Design A randomized, placebo-controlled, double-blind parallel-group study including 20 GH-deficient patients on continued GH replacement therapy. The patients were studied before and after 12 weeks.
Intervention Patients received either pioglitazone 30 mg ( N = 10) or placebo ( N = 10) once daily for 12 weeks.
Results Adiponectin levels almost doubled during pioglitazone treatment ( P = 0·0001). Pioglitazone significantly decreased basal free fatty acid (FFA) levels ( P = 0·02) and lipid oxidation ( P = 0·02). Basal glucose oxidation rate ( P = 0·004) and insulin sensitivity ( P = 0·03) improved in the patients who received pioglitazone treatment. The change in insulin-stimulated adiponectin level after pioglitazone treatment was positively correlated to the change in insulin-stimulated total glucose disposal ( R = 0·69, P = 0·04).
Conclusion The impact of GH on lipolysis and insulin sensitivity can be modified by administration of TZDs. 相似文献
108.
Jenny C. NGAI Fanny W. KO Susanna S. NG Kin‐Wang TO Mabel TONG David S. HUI 《Respirology (Carlton, Vic.)》2010,15(3):543-550
Background and objective: Severe acute respiratory syndrome (SARS) emerged in 2003 and its long‐term sequelae remain largely unclear. This study examined the long‐term outcome of pulmonary function, exercise capacity, health and work status among SARS survivors. Methods: A prospective cohort study of SARS patients at the Prince of Wales Hospital, Hong Kong was conducted, with serial assessments of lung function, 6MWD and 36 item Short Form General Health Survey at 3, 6, 12, 18 and 24 months after disease onset. The work status was also recorded. Results: Serial assessments were completed by 55 of the 123 (39.9%) subjects, of whom 27 were health‐care workers (HCW). The mean age of the group was 44.4 (SD 13.2) years and 19 (34.5%) were males. At 24 months, 10 (18.2%), 9 (16.4%), 6 (10.9%) and 29 (52.7%) subjects had FEV1, FVC, TLC and DLCO < 80% of predicted values, respectively. The mean (SD) 6MWD increased significantly from 439.0 (89.1) m at 3 months to 460.1 (102.8) m at 6 months (P 0.016) and became steady after 6 months. However, 6MWD and 36 item Short Form General Health Survey scores were lower than the normal population throughout the study. Moreover, 29.6% of HCW and 7.1% of non‐HCW had not returned to work 2 years after illness onset. Conclusions: This 2‐year study of a selected population of SARS survivors, showed significant impairment of DLCO, exercise capacity and health status persisted, with a more marked adverse impact among HCW. 相似文献
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