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961.
Background
Advanced ovarian cancer is the leading non-breast gynaecologic cause of malignant pleural effusion. Aim of this study was to assess the efficacy of mitoxantrone sclerotherapy as a palliative treatment of malignant pleural effusions due to ovarian cancer. 相似文献962.
Sasiharan Sithamparanathan Arun Nair Logan Thirugnanasothy J. Gerry Coghlan Robin Condliffe Konstantinos Dimopoulos Charlie A Elliot Andrew J. Fisher Sean Gaine J. Simon R. Gibbs Michael A. Gatzoulis Clive E. Handler Luke S. Howard Martin Johnson David G. Kiely James L. Lordan Andrew J. Peacock Joanna Pepke-Zaba Paul A. Corris 《The Journal of heart and lung transplantation》2017,36(7):770-779
963.
Balafa Olga Zarzoulas Fotis Ikonomou Margarita Xiromeriti Sofia Siamopoulos Konstantinos 《International urology and nephrology》2017,49(2):365-365
International Urology and Nephrology - 相似文献
964.
Lisa Himpel Aziz Wahbi Fanar Mourad Konstantinos Tsagakis Heinz Jakob 《Scandinavian cardiovascular journal : SCJ》2017,51(1):35-39
Objectives. The mechanisms of the location and extension of acute aortic dissection (AD) are only poorly understood. The aim of this study was to compare the cohesion of the non-coronary aortic sinus (NAS) and the ascending aortic wall (AA) using the Dissectometer – a new device for analyses of the mechanical properties of the aorta. Design. The properties of the aortic wall were analyzed with the “Dissectometer” (parameters P7, P8 and P9) in adult patients undergoing aortic root (AR) replacement in two different segments: NAS and AA. The aortic wall thickness (AWT) was measured with a micrometer. Results. Thirty-three adult patients (mean age 65?±?14 years, 80% male) were included in this study. The aortic wall of the NAS was significantly thinner than that of the AA (1.9?±?0.4 vs. 2.3?±?0.4, p?0.01). In contrast, mechanical stability assessed by cohesion testing was diminished in AA samples compared to NAS samples (P7: 86.0?±?55.0 vs. 152.3?±?89.2, p?0.01; P8: 2.5?±?1.3 vs. 6.0?±?3.1, p?0.01; P9: 3.6?±?1.4 vs. 7.8?±?3.2, p?0.01). Conclusions. This study shows that the wall of the AR is characterized by a thin but stable wall, whereas AA was found to be weaker despite its greater thickness. This difference might be involved in the development and spreading of aortic dissections. 相似文献
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Gary Tse Mengqi Gong Julia Nunez Juan Sanchis Guangping Li Sadeq Ali-Hasan-Al-Saegh Wing Tak Wong Sunny Hei Wong William K.K. Wu George Bazoukis Gan-Xin Yan Konstantinos Lampropoulos Adrian M. Baranchuk Lap Ah Tse Yunlong Xia Tong Liu Jean Woo 《Journal of the American Medical Directors Association》2017,18(12):1097.e1-1097.e10
Background
Frailty has been identified as a risk factor for mortality. However, whether frailty increases mortality risk in patients undergoing percutaneous coronary intervention (PCI) has been controversial. Therefore, we conducted a systematic review and meta-analysis of the frailty measures and mortality outcomes in this setting.Methods
PubMed and EMBASE were searched until July 23, 2017 for studies evaluating the association between frailty measures and mortality in individuals who have undergone PCI.Results
A total of 141 entries were retrieved from our search strategy. A total of 8 studies involving 2332 patients were included in the final meta-analysis (mean age: 69 years; 68% male, follow-up duration was 30 ± 28 months). Frailty was a significant predictor of all-cause mortality after PCI, with a hazard ratio (HR) of 2.97 [95% confidence interval (CI) 1.56–5.66, P = .001]. This was substantial heterogeneity present (I2: 79%). Subgroup analysis using the Fried score reduced I2 to 68% without altering the pooled HR (2.78, 95% CI 1.02–7.76; P < .05). Using the Canadian Study of Health and Aging Clinical Frailty Scale reduced I2 to 0% while preserving the pooled HR (5.99, 95% CI 2.77–12.95, P < .001).Conclusions
Frailty leads to significantly higher mortality rates in patients who have undergone PCI. Both the Fried score and Canadian Study of Health and Aging Clinical Frailty Scale are powerful predictors of mortality. These findings may support the notion that an alternative to invasive strategy should be considered in frail patients who are indicated for revascularization. 相似文献967.
Olympia Sideri Konstantinos T. Tsaousis He J. Li Maria Viskadouraki Ioannis T. Tsinopoulos 《Survey of ophthalmology》2019,64(5):668-678
Oxidative stress is one of the main mechanisms of lens opacification, and certain nutritional antioxidants are suspected to have a protective effect. To examine the role of these nutritional antioxidants on cataract prevention, we searched major databases and reviewed current evidence regarding the protective effect of nutritive antioxidants. We included observational studies that investigate the association between one or more of the following micronutrients and cataract: vitamin A, vitamin C, vitamin E, lutein, zeaxanthin, α- and β-carotene. Two independent authors extracted data and assessed their quality. We pooled results for overall cataract incidence for all types of cataract and separately for nuclear, cortical, and posterior subcapsular cataract. We did not perform sensitivity analysis. Twenty-five studies were included in the qualitative and 24 in the quantitative part of the study, with a total of 295,821 participants over 30 years old. Results from pooled analysis showed a protective effect of antioxidants on cataract, but not all of them reached statistical significance. Statistically significant results were reached for vitamin C (odds ratio [OR] = 0.88, 95% confidence interval [CI] [0.81, 0.97]), beta-carotene (OR = 0.89, 95% CI [0.83, 0.95]), and lutein and zeaxanthin (OR = 0.92, 95% CI [0.85, 0.99]). We did not find statistically significant results for vitamin E (OR = 0.84, 95% CI [0.70, 1.01]), vitamin A (OR = 0.90, 95% CI [0.80, 1.00]), or alpha-carotene (OR = 0.92, 95% CI [0.85, 1.00]). The present study shows a relation between certain antioxidants and cataract, but further studies, especially interventional, are needed to confirm this hypothesis. 相似文献
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969.