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51.
Liu JM; Chen YM; Chao Y; Liu SM; Tiu CM; Wu HW; Chiou TC; Hsieh RK; Chen LT; Whang-Peng J 《Japanese journal of clinical oncology》1998,28(7):431-435
BACKGROUND: To evaluate the efficacy and toxicity of cisplatin/etoposide
continuous infusion chemotherapy for cancer of unknown primary site in
Taiwan, a region with a high prevalence of endemic viral infections.
METHOD: Between April 1994 and February 1996, 20 patients with a diagnosis
of CUPS were treated, including 15 males and five females, of average age
63.3 years (range 41-83 years). Continuous intravenous infusion of
etoposide 80 mg/m2 and cisplatin 25 mg/m2 was given for 3 days every 3
weeks. Pretreatment tumor marker and viral serology studies were performed
for baseline evaluation. Nearly two-thirds of the patients had poorly
differentiated carcinoma. The average number of metastatic sites was 2.65
(range 1-4), with liver and lymph node involvement predominating. RESULTS:
The overall response rate was 25% (95% CI 17.7-32.3%); 30.7% for poorly
differentiated cancers and 25% for well differentiated cancers. Median
survival was 4 months (range 1-12 months), 4.8 months for patients
attaining partial response. Toxicity was moderate, grade 3 and 4
neutropenia occurred in 55% and grade 3 and 4 thrombocytopenia in 40%;
other toxicities were mild. CA125 and CA199 were elevated in more than 50%
of patients. Viral serology studies were not significantly different from
those of the indigenous population. CONCLUSION: Etoposide and cisplatin
combination chemotherapy has modest activity in patients with extensive
CUPS and, at the schedule and dosage given, it is associated with moderate
toxicity.
相似文献
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Eran Chemerinski MD Larry J. Siever MD Harold W. Koenigsberg MD 《Current Psychosis and Therapeutics Reports》2005,3(4):162-168
It has recently been proposed that reduced stimulation of prefrontal cortex DI receptors secondary to hypoactivity of mesocortical
dopamine (DA) projections may explain the cognitive impairments experienced by patients with schizophrenia and the schizophrenia
spectrum. Findings from studies done during the past two decades suggest that schizotypal personality disorder (SPD), the
prototypic disorder of the schizophrenia spectrum, is associated with cognitive deficits and social deterioration that are
qualitatively similar, although less severe, to those observed in schizophrenia. It generally is acknowledged that the psychotic
symptoms of schizophrenia are associated with hyperactivity of mesolimbic DA projections resulting in excessive stimulation
of striatal D2 receptors. In contrast with schizophrenia, dopaminergic interventions improved cognitive function in SPD without
worsening psychotic-like symptoms, raising the possibility that patients with SPD are protected against increases in subcortical
dopaminergic activity associated with psychosis. However, mounting evidence suggests that alterations in other neurotransmitter
systems (eg, glutamate, γ-aminobutyric acid, opioid, serotonergic) may be involved in the pathophysiology of schizophrenia.
This over view focuses on common DA-related neurobiological vulnerabilities shared by schizophrenia and the schizophrenia
spectrum, in addition to factors that protect SPD from the overt psychotic symptoms and more severe social and cognitive deficits
experienced by patients with chronic schizophrenia. 相似文献
57.
从头序木(AraliadasyphylaMiq)叶中分离到6个三萜化合物,用化学方法和波谱(UV,IR,MS,1HNMR,13CNMR,13CDEPT,HMQC,HMBC)分析,确定其中4种化合物的结构,分别为齐墩果酸(I),16β羟基18βH齐墩果酸(I),齐墩果酸28OβD吡喃葡萄糖甙(II)和16β羟基18βH齐墩果酸28OβD吡喃葡萄糖甙(IV)。用NOESY谱确定化合物I的立体构型。以上4个化合物均为首次从该植物中分离到,化合物IV为新化合物。 相似文献
58.
R. A. Koenigsberg 《Neuroradiology》1998,40(4):272-273
This report describes image-guided percutaneous aspiration of a symptomatic lumbar synovial cyst, with prompt relief of symptoms.
Received: 22 July 1997 Accepted: 13 October 1997 相似文献
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