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N Kenworthy 《Nurse education today》1985,5(1):37-40
It is becoming the practice in some of the larger schools of nursing to designate a senior member of the teaching staff for the responsibility of curriculum studies; the post is usually that of assistant director of nurse education. Although smaller schools with 200–500 students do not have assistant director posts, it is equally important that curriculum design, development and evaluation is carried out. This paper describes the attempt by one school of nursing to overcome the problem of finding the time to concentrate on curriculum planning and the emergence of a teaching structure based on tutor specialisation. With a new general nursing syllabus promised by the English National Board it is important that schools of nursing should address themselves to this area of educational management. 相似文献
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Influence of bacteria on absorption from the small intestine 总被引:1,自引:0,他引:1
R Kenworthy 《The Proceedings of the Nutrition Society》1967,26(1):18-23
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Oliveras-Rentas RE Kenworthy L Roberson RB Martin A Wallace GL 《Journal of autism and developmental disorders》2012,42(5):655-664
Changes in the Wechsler Intelligence Scales for Children-IV (WISC-IV) may affect the IQ profile characteristic of autism spectrum
disorders (ASD). Moreover, the association of particular component cognitive abilities (unlike overall IQ) with symptomatology
and adaptive functioning in ASD remains unclear. This archival study characterizes the WISC-IV IQ profile among 56 high-functioning
(IQ > 70) children with ASD and correlates WISC-IV performance with ASD and ADHD symptomatology and adaptive functioning.
The ASD WISC-IV profile included strengths on Matrix Reasoning and Similarities, weaknesses on Comprehension (which correlated
negatively with social symptoms) and the subtests comprising the Processing Speed Index (Coding, Symbol Search). Processing
speed task performance correlated negatively with communication symptoms and positively with communication abilities, indicating
its importance to functional outcomes in ASD. 相似文献
17.
Goodman M Squibb K Youngstrom E Anthony LG Kenworthy L Lipkin PH Mattison DR LaKind JS 《Ciência & saúde coletiva》2011,16(7):3207-3220
We examined prospective cohort studies evaluating the relation between prenatal and neonatal exposure to polychlorinated biphenyls (PCBs) and neurodevelopment in children to assess the feasibility of conducting a meta-analysis to support decision making. We described studies in terms of exposure and end point categorization, statistical analysis, and reporting of results. We used this evaluation to assess the feasibility of grouping studies into reasonably uniform categories. The most consistently used tests included Brazelton's Neonatal Behavioral Assessment Scale, the neurologic optimality score in the neonatal period, the Bayley Scales of Infant Development at 5-8 months of age, and the McCarthy Scales of Children's Abilities in 5-year-olds. Despite administering the same tests at similar ages, the studies were too dissimilar to allow a meaningful quantitative examination of outcomes across cohorts. These analyses indicate that our ability to conduct weight-of-evidence assessments of the epidemiologic literature on neurotoxicants may be limited, even in the presence of multiple studies, if the available study methods, data analysis, and reporting lack comparability. 相似文献
18.
John F. Strang Aron Janssen Amy Tishelman Scott F. Leibowitz Lauren Kenworthy Jenifer K. McGuire Laura Edwards-Leeper Carla A. Mazefsky Dana Rofey Julia Bascom Reid Caplan Veronica Gomez-Lobo Dianne Berg Zosia Zaks Gregory L. Wallace Harriette Wimms Elyse Pine-Twaddell Daniel Shumer Laura G. Anthony 《Journal of the American Academy of Child and Adolescent Psychiatry》2018,57(11):885-887
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D Iusuf RW Sparidans A van Esch M Hobbs KE Kenworthy E van de Steeg E Wagenaar JH Beijnen AH Schinkel 《Molecular pharmaceutics》2012,9(9):2497-2504
Organic anion-transporting polypeptides (OATPs) mediate the hepatic uptake of many drugs. Hepatic uptake is crucial for the therapeutic effect of pravastatin, a cholesterol-lowering drug and OATP1A/1B substrate. We aimed to gain empirical insight into the relationship between OATPs and pravastatin pharmacokinetics and toxicity. We therefore compared the distribution and toxicity of pravastatin in wild-type and Oatp1a/1b-null mice. Intestinal absorption of pravastatin was not affected by Oatp1a/1b absence, but systemic plasma exposure (AUC) increased up to 30-fold after oral bolus administration. This increased plasma exposure resulted from reduced hepatic uptake, as evident from 10 to 100-fold lower liver-to-plasma concentration ratios. However, the reductions in liver exposure were far smaller (<2-fold) than the increases in plasma exposure. Reduced pravastatin liver uptake in Oatp1a/1b-null mice was more obvious shortly after intravenous administration, with 8-fold lower biliary pravastatin excretion. Although mice chronically exposed to pravastatin for 60 days evinced little muscular toxicity, Oatp1a/1b-null mice displayed 10-fold higher plasma concentrations and 8-fold lower liver concentrations than wild-type mice. Thus, Oatp1a/1b transporters importantly control the hepatic uptake of pravastatin. Activity-reducing human OATP1B polymorphisms may therefore both reduce pravastatin therapeutic efficacy in the liver and increase systemic toxicity risks, thus compromising its therapeutic index in a two-edged way. 相似文献
20.
Lauren Kenworthy Gregory L. Wallace Kelly Powell Cheryl Anselmo Alex Martin David O. Black 《Research in autism spectrum disorders》2012,6(3):1194-1202
Language ability is a known predictor of outcome in children with autism but plays a more controversial role for higher functioning children with autism spectrum disorders (ASD). We studied the relationship between early language milestones and later structural language, adaptive functioning and autism symptoms in a sample of 76 children (mean age = 9.1 years) with an ASD, using two different language milestones: first phrase by 24 or 36 months. After controlling for age and nonverbal abilities, retrospectively reported early language milestones were predictive of later structural language abilities, measured by a sentence repetition task, and adaptive communication skills, but not autism symptoms or adaptive social skills. Acquisition of phrase speech by 24 months was sensitive to language and communication impairments in our ASD group, the majority (84%) of which had already acquired phrase speech by 36 months of age. Early available and easily collectable milestone data may be a useful marker of later language performance even in higher functioning, verbal children on the autism spectrum. When a detailed assessment of language is not possible, data on early milestones may be useful for identifying children at-risk in clinical settings and for language phenotyping in the laboratory. 相似文献