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51.
Seishi Aihara Shunsuke Yamada Satoru Shichijo Kento Fukumitsu Mika Kondo Yutaro Hirashima Hideaki Oka Taro Kamimura Atsumi Harada Toshiaki Nakano Kazuhiko Tsuruya Takanari Kitazono 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2020,24(1):34-41
Vascular access intervention therapy (VAIVT) is necessary to maintain vascular access in patients undergoing hemodialysis. VAIVT‐associated vasodilatation is painful. However, few reports have focused on effective pain relief at the time of VAIVT. The present study was performed to determine whether lidocaine‐propitocain cream, a eutectic mixture of local anesthetics (EMLA), effectively reduces VAIVT‐associated pain in patients undergoing hemodialysis. This placebo‐controlled, double‐blind, crossover study was conducted in a single center. Among 210 patients who underwent a total of 437 VAIVT procedures from August 2017 to June 2018, 30 patients were randomly allocated to either the EMLA–placebo arm or placebo–EMLA arm at the time of VAIVT. EMLA application significantly reduced the visual analog scale score compared with placebo (47.0 ± 21.1 vs. 68.6 ± 20.7 mm, respectively; P < 0.05). EMLA is a safe and effective treatment for relief of VAIVT‐associated pain in patients undergoing hemodialysis. 相似文献
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Keiichi Hosaka Antonin Tichy Masaomi Ikeda Keiichi Nakagawa Alireza Sadr Junji Tagami Masahiro Takahashi Kento Sato Yoshihiro Nishitani Celso Afonso Klein-Junior David H. Pashley Masatoshi Nakajima 《Dental materials》2019,35(7):e153-e161
ObjectivesUltra-high-speed (UHS) videography was used to visualize the fracture phenomena at the resin–dentin interface during micro-tensile bond strength (μTBS) test. We also investigated whether UHS videography is applicable for failure-mode analysis.MethodsTen human mid-coronal dentin surfaces were bonded using Clearfil SE Bond either in self-etching (SE) or etch-and-rinse (ER) mode. After 24-h water storage, the samples were cut into beams for μTBS test and tested at a cross-head speed of 1 mm/min. The fracture phenomena at the bonded interface were captured using a complementary metal–oxide–semiconductor digital UHS camera at 299,166 frames per second. The failure modes were classified using UHS videography, followed by scanning electron microscopy (SEM) analysis. The failure-mode distributions determined by UHS videography and SEM analysis were statistically analyzed using Fisher’s exact test with Bonferroni correction.ResultsThe crack-propagation speed exceeded 1,500 km/h. No significant difference was found between the SEM and UHS videography failure-mode distributions in the SE mode. A significant difference appeared between them in the ER mode. Significant differences in the incidence of cohesive failures within the adhesive and at the adhesive–composite interface between the SE and ER modes were identified by both SEM and UHS videography.SignificanceUHS videography enabled visualization of the fracture dynamics at the resin– dentin interfaces under tensile load. However, the resolution at such high frame rate was insufficient to classify the failure mode as precisely as that of SEM. Nevertheless, UHS videography can provide more detailed information about the fracture origin and propagation. 相似文献
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Asakura H 《Gastroenterology》2012,142(3):e27-8; author reply e28-9
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Tomoki Ueda Rioko Iino Kenji Yokoyama Shinichiro Okamoto Keiko Asakura Yuiko Tsukada Jo Ishizawa Eri Matsuki Yasuo Ikeda Yutaka Hattori 《International journal of hematology》2012,96(4):477-484
In order to test for improved survival following autologous transplantation (ASCT), we conducted a prospective clinical trial of post-ASCT thalidomide therapy in Japanese patients with multiple myeloma (MM). Twenty-five newly diagnosed patients received double or single ASCT with high-dose melphalan (200?mg/m2). Two months after stem cell infusion, if the patients failed to achieve a near-complete response, thalidomide was administered at 200?mg/day until disease progression or occurrence of intolerable adverse events. Seventeen patients were in partial response or minimal response after ASCT and received thalidomide alone. Their median progression-free survival (PFS) from ASCT was 17.4?months, and the median overall survival (OS) was 42.9?months. Some patients with normal karyotype experienced durable disease stabilization for over 5?years. Five patients who exhibited high-risk chromosomal changes such as t(4;14) or deletion of chromosome 13 or 17 showed very short PFS and OS compared with those who did not. Observed grade 3 or 4 toxicities included infection in three patients, hematological toxicities in three, and gastrointestinal toxicities in two, but there was no grade 3 or higher peripheral neuropathy, probably due to appropriate dose modifications. This long-term prospective study is the first to demonstrate the feasibility of post-ASCT thalidomide therapy in Japanese patients with MM. 相似文献
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The effect of the addition of alcohol to a Na3PO4-based electrolyte on plasma electrolytic oxidation (PEO) of AZ31B magnesium alloy was investigated. Anodization with spark discharge was conducted in Na3PO4-based electrolyte containing various alcohols (e.g., ethanol, ethylene glycol, and glycerol) at a constant current density of 200 A m−2 and a constant temperature of 25 °C. Voltage–time curves during the PEO process, the film structure, surface roughness, crystallographic structure, composition, corrosion resistance, and withstand voltage were investigated using various analytical equipment and electrochemical measurements. When the electrolyte containing alcohol was used, the initial bending voltage was higher than that observed using the basic electrolyte without alcohol addition, as was the oscillation voltage during the PEO process. For a given amount of electricity supplied, the addition of alcohol into the basic electrolyte tended to increase the thickness and corrosion resistance of PEO films formed while effectively reducing surface roughness. In particular, the addition of a polyhydric alcohol (i.e., ethylene glycol and glycerol) could act not only as a leveler for the formation of compact film but also as an enhancer for film qualities, such as corrosion resistance and withstand voltage. The patterns observed for Na3PO4-based electrolyte containing alcohol also hold for Na2SiO3-based electrolyte containing alcohol.Alcohol used as an additive could act not only as a leveler for the formation of compact film but also as an enhancer for film qualities, such as corrosion resistance and withstand voltage. 相似文献
58.
Nonanastomotic rupture of thoracic aortic Dacron graft treated by endovascular stent graft placement
Seiichi Yamaguchi Toshihisa Asakura Sumio Miura Takao Ohki Yuji Kanaoka Hiroki Ohta Noriyuki Yajima Mitsuru Nakaya 《General thoracic and cardiovascular surgery》2013,61(7):414-416
A 61-year-old man had a Stanford type A acute aortic dissection, and the total aortic arch was replaced with 22-mm knitted Dacron graft in 1996. In 2006, he underwent mitral valve replacement and tricuspid valve repair due to severe mitral and tricuspid valve regurgitation. Although preoperative computed tomography (CT) scan suggested pseudoaneurysm around the Dacron graft replaced with aortic arch, it could not be repaired concomitantly. Four months later, in view of the technical difficulties of an open surgical procedure, the prosthetic graft failure was repaired by endovascular stent graft consisting of a Gianturco Z stent covered with an UBE woven Dacron graft. However, during a follow-up, aneurysm sac diameter increased without any sings of endoleak in follow-up CT scans. Redo endovascular stent graft placement using a Gore-TAG device was performed. Subsequently, shrinkage of the pseudoaneurysmal sac could be observed. 相似文献
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