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Alexandra M. Burgess Kelsie H. Okamura Sonia C. Izmirian Charmaine K. Higa-McMillan Scott Shimabukuro Brad J. Nakamura 《The journal of behavioral health services & research》2017,44(3):414-427
Despite the accumulated research support for the use of evidence-based practices (EBPs) with youth, these treatment approaches remain underutilized in community settings. Therapist attitudes towards EBPs play a pivotal role in their adoption and implementation of these practices. The present investigation employs joint exploratory factor analysis to evaluate the structure of two measures of therapist attitudes, the Evidence-Based Practices Attitudes Scale and the Modified Practice Attitude Scale. Results suggest three factors including (a) importance of clinical experience over EBPs, (b) clinician openness to change, and (c) problems with EBPs. Recommendations are provided for future evaluation of therapist attitudes and associated characteristics. 相似文献
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Kelsie H. Okamura Puanani J. Hee David Jackson Brad J. Nakamura 《Administration and policy in mental health》2018,45(5):699-708
Examining therapist evidence-based practice (EBP) knowledge seems an important step for supporting successful implementation. Advances in implementation science suggest a distinction between practice specific (i.e., knowing which practices are derived from the evidence base) and EBP process (i.e., integrating research evidence, clinical experience, client characteristics, and monitoring outcomes) knowledge. An examination of how these knowledge types are measured and relate to attitudes appears warranted. In our sample of 58 youth community therapists, both practice specific and EBP process knowledge accounted for EBP attitude scores, which varied by therapist demographic variables. Implications for measurement of therapist constructs and future research in identifying therapist predictors of EBP use and youth clinical improvement are discussed. 相似文献
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GilbertM. Rishton Gary C. Look Zhi-Jie Ni Jason Zhang Yingcai Wang Yaodong Huang Xiaodong Wu Nicholas J. Izzo Kelsie M LaBarbera Colleen S. Limegrover Courtney Rehak Raymond Yurko Susan M. Catalano 《ACS medicinal chemistry letters》2021,12(9):1389
An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented and reversed synaptotoxic effects of Aβ oligomers in neurons were discovered to bind to the sigma-2 receptor complex. Select development compounds displaced receptor-bound Aβ oligomers, rescued synapses, and restored cognitive function in transgenic hAPP Swe/Ldn mice. Our first-in-class orally administered small molecule investigational drug 7 (CT1812) has been advanced to Phase II clinical studies for Alzheimer’s disease. 相似文献
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Kelsie Bogyo Natalie Vena Halie May Hila Milo Rasouly Maddalena Marasa Simone Sanna-Cherchi Krzysztof Kiryluk Jordan Nestor Ali Gharavi 《American journal of medical genetics. Part C, Seminars in medical genetics》2022,190(3):289-301
Studies have shown that as many as 1 in 10 adults with chronic kidney disease has a monogenic form of disease. However, genetic services in adult nephrology are limited. An adult Kidney Genetics Clinic was established within the nephrology division at a large urban academic medical center to increase access to genetic services and testing in adults with kidney disease. Between June 2019 and December 2021, a total of 363 patients were referred to the adult Kidney Genetics Clinic. Of those who completed genetic testing, a positive diagnostic finding was identified in 27.1%, a candidate diagnostic finding was identified in 6.7% of patients, and a nondiagnostic positive finding was identified in an additional 8.6% of patients, resulting in an overall yield of 42.4% for clinically relevant genetic findings in tested patients. A genetic diagnosis had implications for medical management, family member testing, and eligibility for clinical trials. With the utilization of telemedicine, genetic services reached a diverse geographic and patient population. Genetic education efforts were integral to the clinic's success, as they increased visibility and helped providers identify appropriate referrals. Ongoing access to genomic services will remain a fundamental component of patient care in adults with kidney disease. 相似文献
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Okamura Kelsie H. Orimoto Trina E. Nakamura Brad J. Chang Bree Chorpita Bruce F. Beidas Rinad S. 《The journal of behavioral health services & research》2021,48(1):156-157
The Journal of Behavioral Health Services & Research - On page 73 in the Methods section, we added clarification to the criteria applied for counting practice elements that would eliminate an... 相似文献
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