超声引导下临时心脏起搏电极心内定位的临床应用

目的：探讨应用超声引导临时心脏起搏电极心内定位的可行性和这一新方法的实用价值。方法：经皮穿刺右侧颈内静脉或右侧锁骨下静脉,在超声引导下将起搏电极送至右室心尖部进行临时起搏。结果：21例患者均能顺利地将电极定位在右室心尖部并能成功起搏。结论：应用超声替代X光行临时心脏起搏器安装术具有实用价值,值得临床推广应用。     

Treatment of neurofibromatosis with Chinese herbal drugs.

Neurofibromatosis is a dominantly inheriteddefect of the ectoderm,characterized by cafe au laitspots since the childhood and multiple tumorsderived from elements of peripheral and cranialnerves.Hernia-like tumors of various sizes can oftenbe felt under the skin and serve as a valuablecharacteristic in making diagnosis.However,theycan also affect brain,vegetative nerve system or othertissues and lead to bony abnormalities,mentaldisturbances and sometimes,endocrine abnormalities,     

超声评价低频脉冲中药导入治疗乳腺囊性增生病临床疗效

目的：超声观察低频脉冲中药导入治疗乳腺囊性增生病的临床疗效。方法：将１５０例患者随机分为治疗组（１００例）和口服乳增宁片对照组（５０例）,超声观察治疗前后乳腺病变组织的变化情况。结果：经２个疗程治疗后,治疗组治愈率６２％,总显效率８３％,总有效率９８％;对照组治愈率３６％,总显效率６６％,总有效率９０％。治疗组的治愈率和总显效率均显著优于对照组（Ｐ〈０．０１,Ｐ〈０．０５）。结论：低频脉冲中药导入     

2型糖尿病及其血管并发症患者血清ACE活性的变化

This investigation was made with reference to the changes of serum angiotensin converting enzyme (SACE) activity in type 2 diabetes and its vascular complications. SACE activity was studied in 127 type 2 diabetic patients and 90 healthy persons by using a spectrophotometric assay. The results showed SACE activity was obviously higher in diabetic patients (459.51 +/- 175.85 U) than in healthy persons (321.14 +/- 121.27 U); SACE activity was significantly higher in type 2 diabetic patients with diabetic nephropathy (548.27 +/- 166.60 U) than in patients without diabetic nephropathy (383.2 +/- 139.00 U), but there was no difference between patients with microalbuminuria and macroalbuminuria; no statistical difference was detected in SACE activity between diabetic patients with diabetic retinopathy (465.64 +/- 178.93 U) and without retinopathy (449.07 +/- 170.04 U); SACE activity was not associated with the course of diabetes, blood pressure, blood lipid and blood glucose. These data suggest that raised SACE activity might only play a role in the initiation of type 2 diabetes and diabetic nephropathy, but not relate to the progress of diabetic nephropathy, the onset of diabetic retinopathy and hypertension.     

中国3766例非综合征性总唇裂的分析

为了解我国１９８８￣１９９２年非综合征性总唇裂的流行病学特征及发生率的动态变化趋势,采用以医院为单位的整群抽样方法,对全国５００所医院孕２８周至产后７天的３２４６４０８例围产儿,３７６６例非综合征性总唇裂病例进行性分析。结果：我国非综合征性总唇裂发生率为１１．６／万,其中单纯性唇裂为３．８／万,唇裂合并腭裂为７．８／万,５年发生率无显著性差异（Ｐ〉０．１）。城乡非综合征性总唇裂的发生率（１１．７／     

ACEI治疗肾性高血压和对肾机能的保护作用

OBJECTIVE: To explore the influence of angiotensin-converting enzyme inhibitors (ACEI) on plasma endothelin (ET-1), nitric oxide (NO) and renal function in renal-hypertension patients. METHODS: Sixty renal-hypertension patients (Group II) were treated with ACEI (lotensin) for 10 weeks then we measure their blood pressure (BP), plasma ET-1, NO and renal functions (BUN, Scr and proteinuria) before and after the treatment. Thirty healthy persons (Group I) acted as control. RESULTS: The level of plasma ET-1 was higher and plasma NO was lower in Group II than those in Group I. After the treatment of ACEI plasma ET-1 and proteinuria were decreased (P < 0.01), and NO increased in Group II significantly (P < 0.01), while BUN and Scr decreased in abnormal-renal function patients (Group II2) (P < 0.05, P < 0.01). CONCLUSION: The Study indicates that: ACEI is effective to renal hypertension; it decreases plasma ET-1 and increases NO in the renal hypertension patients; ACEI may play an important role in protection of renal functions and prolonging the chronic renal failure.     

γ射线诱导人肝癌细胞表达B7-1共刺激分子的研究

目的　研究电离辐射与肿瘤细胞B7- 1分子表达之间的关系 ,探讨肿瘤细胞辐照后免疫原性增强的机制。方法　采用间接免疫荧光 -流式细胞仪分析技术 ,研究在用不同剂量γ射线照射SMMC - 772肝癌细胞后、培养不同时间内SMMC - 772细胞B7- 1共刺激分子的表达水平。并用3H -TdR释放法测定照射和未照射肿瘤细胞与淋巴细胞共反应后的细胞毒活性。结果　未照射和经 10、2 0、30Gy照射的人肝癌细胞不表达B7- 1分子。经 40、5 0、6 0Gy剂量照射后 ,SMMC - 772肝癌细胞表达B7- 1分子 ,最高达 6 6 .8± 1.3% ,与对照组比有非常显著性差异 (P <0 .0 1)。表达时间的高峰在照射后培养 72h时 ,最低在照射后培养 2 4h时 (P <0 .0 5 )。细胞毒活性测定结果表明 ,表达B7- 1分子的SMMC - 72肝癌细胞与淋巴细胞共反应后 ,细胞毒活性明显高于未照射组 (P <0 .0 1)。结论　γ射线可诱导肝癌细胞表达B7- 1分子 ,从而增强肿瘤细胞的免疫性     

影响淋巴细胞共刺激作用的体外实验研究

目的　观察CD3单抗、CD2 8单抗、PHA和低剂量辐射对淋巴细胞增殖的影响 ,探讨影响T淋巴细胞信号转导的因素。方法　分别以CD3单抗、CD2 8单抗、PHA和低剂量辐射作为作用因素 ,用3H TdR掺入法观察在这些因素作用下 ,淋巴细胞增殖反应情况。结果　CD3单抗和CD2 8单抗联合刺激、PHA和低剂量辐射单独或联合处理 ,均可使淋巴细胞明显增殖。但CD3单抗和CD2 8单抗单独刺激 ,淋巴细胞增殖不明显。结论　CD3单抗和CD2 8单抗联合作用可使淋巴细胞有效增殖 ,PHA和低剂量辐射具有相似作用 ,对细胞免疫调节有重要意义     

树立新观念 搞好高校教材工作改革

社会主义市场经济必然要求高校教材走向市场。教材管理者、学校领导和师生都必须树立新观念。坚持社会效益首位前提下的双重效益观念是搞好主校教材工作改革的关键     

老年人肺癌并发院内获得性肺炎的临床研究

目的为探讨老年人肺癌院内获得性肺炎的临床特点、病原菌及耐药情况,为临床提供依据。方法分析72例老年人肺癌并发院内获得性肺炎的临床资料。结果老年人肺癌平均住院日期延长,化疗时不合理使用抗菌药物,发生院内获得性肺炎的机会最大。主要病原菌为G~-杆菌占80.70％,其中以铜绿假单胞菌、肺炎克雷伯氏菌为主,其次为表皮葡萄球菌占10.53％。病原菌对氨苄青霉素、哌拉西林、头孢菌素耐药性增加,对亚胺培南、万古霉素、阿米卡星敏感。病死率达30.56％。结论老年人肺癌免疫功能低下,住院日期延长,不合理使用抗生素是造成院内感染的主要因素。病原菌的耐药率呈增加趋势,病死率较高。