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排序方式: 共有760条查询结果,搜索用时 15 毫秒
751.
Egan JJ Remund KF Corris P 《The New England journal of medicine》2008,358(18):1963-4; author reply 1964
752.
Signe Winther‐Jrgensen Marietta Nygaard Carsten Heilmann Marianne Ifversen Kaspar Srensen Klaus Müller Tania Masmas 《Pediatric transplantation》2019,23(4)
Graft‐versus‐host disease (GVHD) is a main cause of morbidity and mortality following hematopoietic stem cell transplantation. The cumulative incidence of acute and chronic GVHD (aGVHD, cGVHD) reaches 30%‐50% and 20% in pediatric populations, respectively. Prednisolone and/or calcineurin inhibitors (CNI) are first‐line treatments, but no superior second‐line treatment has yet been established. Several treatments have been suggested, among others extracorporeal photopheresis (ECP). Technical advances have made treatment of pediatric patients possible; however, only few reports on the feasibility of ECP in children have been published. We retrospectively studied the feasibility, safety, and efficacy of ECP in 15 children with steroid‐dependent/refractory acute or chronic GVHD, who initiated ECP treatment between April 2014 and January 2018. Only few and mild side effects directly related to the ECP procedure were registered, even in patients with low body weight. The most frequent cause of shortened or canceled ECP treatment was difficulties with vascular accesses, which were more rarely seen using central venous catheters with larger lumens and made of stiffer material. Nine patients had grade II‐III aGVHD. Six of these experienced a response to ECP at day 28, while eight of nine had responded at the last ECP treatment. Six patients had cGVHD when ECP was initiated, and of these, four had a partial response at last ECP treatment. We found ECP to be a feasible and safe treatment, and particularly, children with aGVHD appeared to respond well to ECP. 相似文献
753.
754.
755.
M. Kaspar 《Archives of orthopaedic and trauma surgery》1944,43(1):126-130
Ohne Zusammenfassung 相似文献
756.
Camous Moslemi Susanne G. Sækmose Rune Larsen Jakob T. Bay Thorsten Brodersen Maria Didriksen Henrik Hjalgrim Karina Banasik Kaspar R. Nielsen Mie T. Bruun Joseph Dowsett Khoa M. Dinh Susan Mikkelsen Christina Mikkelsen Thomas F. Hansen Henrik Ullum Christian Erikstrup Søren Brunak Karen Angeliki Krogfelt Jill R. Storry Sisse R. Ostrowski Martin L. Olsson Ole B. Pedersen 《Transfusion》2023,63(12):2297-2310
757.
Werner Guido Abu Sin Muna Bahrs Christina Brogden Sandra Feßler Andrea T. Hagel Stefan Kaspar Heike Köck Robin Kreienbrock Lothar Krüger-Haker Henrike Maechler Frederike Noll Ines Pletz Mathias W. Tenhagen Bernd-Alois Schwarz Stefan Walther Birgit Mielke Martin 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2023,66(6):628-643
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - „One Health“ bezeichnet ein Konzept, das die Gesundheit von Menschen, Tieren und der Umwelt miteinander verbindet. In... 相似文献
758.
Tina Gerbek Birthe Lykke Thomsen Ena Muhic Terkel Christiansen Kaspar Sørensen Marianne Ifversen Klaus Kofoed Klaus Müller 《Pediatric transplantation》2023,27(4):e14530
Background
Metabolic syndrome (MetS) is frequent among survivors of childhood hematopoietic stem-cell transplantation (HSCT), but assessment of risk factors is challenged by survivor and participation bias in long-term follow-up studies.Methods
A cohort of 395 pediatric patients transplanted between 1980 and 2018 was investigated. MetS was assessed at follow-up between December 2018 and March 2020. Two composite outcomes ((a) combining MetS and death, (b) combining MetS, death, and nonparticipation) were considered to address the risk of selection bias.Results
Among 234 survivors invited to the follow-up, 96 individuals (median age 27 years) participated. MetS prevalence was 30% among participants. The only significant HSCT risk factor was a variable combining HSCT indication and conditioning with total-body irradiation (TBI) (p = .0011). Compared to acute leukemias (AL) treated with high-grade TBI (8–12 Gy), a lower MetS prevalence was seen for nonmalignant diseases treated with no/low-grade TBI (0–4.5 Gy) (OR = 0.04, 95% confidence interval (CI): 0.00–0.23). Analyses of the composite outcomes indicated overestimation of the effect of high-grade TBI due to selection bias. Scrutiny showed strong residual confounding between HSCT indication and high-grade TBI within AL-patients. The HSCT effect on MetS reflected HSCT effects on high-density-lipoprotein (HDL) and triglycerides. Compared to AL treated with high-grade TBI, nonmalignant diagnoses treated with no/low-grade TBI had higher HDL (+40%, 95% CI: +21% to +62%) and lower triglyceride (−59%, 95% CI: −71% to −42%).Conclusion
The TBI effect on MetS may be overestimated in follow-up studies due to selection bias and confounding. The TBI effect was confined to the potentially modifiable MetS criteria HDL and triglyceride. 相似文献759.
Mona Ameri Chalmer Lisette J. A. Kogelman Ida Callesen Charlotte Grønvold Christensen Tanya Ramdal Techlo Peter L. Møller Olafur B. Davidsson Isa A. Olofsson Michael Schwinn Susan Mikkelsen Khoa Manh Dinh Kaspar Nielsen Mie Topholm Christian Erikstrup Sisse Rye Ostrowski Ole Birger Pedersen DBDS Genomic Consortium Henrik Hjalgrim Karina Banasik Kristoffer S. Burgdorf Mette Nyegaard Jes Olesen Thomas Folkmann Hansen 《European journal of neurology》2023,30(6):1774-1784
Background and purpose
Understanding migraine in a sex-specific manner is crucial for improving clinical care, diagnosis and therapy for both females and males. Here, data on sex differences are provided in the presentation of migraine in a large European-based population cohort, which is representative of the general population.Methods
A population-based study of 62,672 Danish blood donors (both present and previous donors), of whom 12,658 had migraine, was performed. All participants completed a 105-item diagnostic migraine questionnaire sent via an electronic mailing system (e-Boks) between May 2020 and August 2020. The questionnaire allowed for correct diagnosis of migraine according to the International Classification of Headache Disorders, third edition.Results
The migraine questionnaire was in-cohort validated and had a positive predictive value of 97% for any migraine, a specificity of 93% and a sensitivity of 93%. There were 9184 females (mean age 45.1 years) and 3434 males (mean age 48.0 years). The 3-month prevalence of migraine without aura was 11% in females and 3.59% in males. The 3-month prevalence of migraine with aura was 1.72% in females and 1.58% in males. In females, the age-related 3-month prevalence of migraine without aura increased markedly during childbearing age. In males, migraine both with and without aura showed less age variation. Females had a higher frequency of migraine attacks (odds ratio [OR] 1.22) but a lower frequency of non-migraine headaches (OR = 0.35). Females also had a greater intensity of pain, more unilateral and pulsatile pain, and exacerbation by physical activity (OR = 1.40–1.49) as well as more associated symptoms (OR = 1.26–1.98). Females carried 79% of the total migraine disease burden, which was almost exclusively driven by migraine without aura (77%), whilst there was no sex difference in the disease burden of migraine with aura.Conclusion
Females have more severe disease, resulting in a much higher migraine disease burden than indicated by prevalence alone. 相似文献760.
Camous Moslemi Susanne Sækmose Rune Larsen Thorsten Brodersen Maria Didriksen Henrik Hjalgrim Karina Banasik Kaspar R. Nielsen Mie T. Bruun Joseph Dowsett Kathrine A. Kasperen Susan Mikkelsen Thomas F. Hansen Henrik Ullum Christian Erikstrup Martin L. Olsson Sisse R. Ostrowski Ole B. Pedersen 《Transfusion》2023,63(1):47-58