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排序方式: 共有734条查询结果,搜索用时 343 毫秒
61.
High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice 总被引:1,自引:0,他引:1
62.
Primary leiomyosarcoma of broad ligament 总被引:1,自引:0,他引:1
Ben Amara F Jouini H Nasr M Malek M Neji K Reziga H Mrad K Ben Romdhane K 《La Tunisie médicale》2007,85(7):591-595
BACKGROUND: Primary broad ligament leiomyosarcoma (LMS) is an extremely rare tumor with few well-documented cases. We are aware of 15 previously reported observations. AIM: Report of a new case. CASE: In this report we report a case of a right pelvic sidewall leiomyosarcoma with involvement of the appendix in a 49-year-old woman. A hysterectomy, bilateral salpingo-oophorectomy, omentectomy and appendicectomy were done, without complications. The patient died five months later. The case illustrates the difficulty of correct diagnosis before intervention. On this occasion, review of the literature confirms that this site remains unusual and the management is difficult. 相似文献
63.
Emeline Tabouret Michel Fabbro Didier Autran Khe Hoang-Xuan Luc Taillandier François Ducray Maryline Barrie Marc Sanson Christine Kerr Stephanie Cartalat-Carel Anderson Loundou Remy Guillevin Karima Mokhtari Dominique Figarella-Branger Jean-Yves Delattre Olivier Chinot 《The oncologist》2021,26(8):647-e1304
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Mathilde Duchesne Stéphane Mathis Philippe Corcia Laurence Richard Karima Ghorab Arnaud Jaccard Laurent Magy Jean-Michel Vallat 《Medicine》2015,94(3)
Hematological malignancies include several diseases that may affect the peripheral nervous system (PNS) through various mechanisms. A common and challenging situation is represented by the occurrence of an active peripheral neuropathy in a patient with a supposed inactive hematological disorder.We report clinical, electrophysiological, biological, and pathological data of 8 patients with latent malignant hemopathies (most were considered in remission): B-cell chronic lymphocytic leukemia in 3 patients, B-cell lymphoma in 1 patient, low-grade non-Hodgkin''s lymphoma in 1 patient, Waldenström''s macroglobulinemia in 1 patient, smoldering multiple myeloma in 1 patient, and monoclonal gammopathy of undetermined significance in 1 patient.In all these cases, the nerve biopsy (NB) helped to diagnose the hematological relapse or detect a pathological mechanism linked to the hematological disorder: epineurial lymphocytic infiltration in 5 patients (including one with antimyelin-associated glycoprotein antibodies), cryoglobulin deposits in 1 patient, chronic inflammatory demyelinating polyneuropathy in 1 patient, and necrotizing vasculitis in 1 patient. In each case, pathological findings were crucial to select the adequate treatment, leading to an improvement in the neurological and biological manifestations.These observations illustrate the value of NB and the need for active collaboration between neurologists and hematologists in such cases. 相似文献
68.
Abourazzak FE Benbouazza K Amine B Bahiri R Lazrak N Bzami F Jroundi I Abouqal R Guillemin F Hajjaj-Hassouni N 《Rheumatology international》2008,28(12):1197-1203
Objective of the study is to test the reliability and validity of a translated version of health assessment questionnaire (HAQ) on Moroccan patients with rheumatoid arthritis (RA). We led a prospective study from July 2004 to September 2005. A total of 100 Moroccan patients were recruited. After translation to dialect Arabic, back translation, expert committee review and pretesting of the questionnaire, it was administered to the selected patients and tested for construct validity, reliability and internal consistency. The construct validity was evaluated by correlating the yield of the questionnaire with other disease activity and severity parameters. The questionnaire was administered again after a time interval of between 2 and 10 days for evaluation of the reliability of this test. All the items were tested for their loyalty to the principal component. The adapted questionnaire showed a good internal consistency. Cronbach's alpha test was 0.994. The test-retest showed a strong reliability with a kappa test ranging from 0.70 to 0.92 for all domains. Intraclass correlation coefficient for the total score was 0.987. The Moroccan HAQ showed a strong validity. It correlates significantly with disease activity and severity parameters. The unidimentionality has been demonstrated. About 71.5% of all variabilities was accounted for by the first principal component. The Moroccan Arabic dialect version of HAQ is a reliable and valid instrument that can be self-administered by Moroccan RA patients to assess their functional disability. 相似文献
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Anna Luisa Di Stefano Marianne Labussiere Giuseppe Lombardi Marica Eoli Donata Bianchessi Francesco Pasqualetti Patrizia Farina Stefania Cuzzubbo Jaime Gallego-Perez-Larraya Blandine Boisselier Francois Ducray Caroline Cheneau Arrigo Moglia Gaetano Finocchiaro Yannick Marie Amithys Rahimian Khe Hoang-Xuan Jean Yves Delattre Karima Mokhtari Marc Sanson 《Journal of neuro-oncology》2015,121(3):499-504