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101.
Akyüz F Demir K Ozdil S Aksoy N Poturoğlu S Ibrişim D Kaymakoğlu S Beşişik F Boztaş G Cakaloğlu Y Mungan Z Cevikbaş U Okten A 《Digestive diseases and sciences》2007,52(9):2359-2367
Our aım was to evaluate effects of metformin, rosiglitazone, and diet with exercise in nonalcoholic fatty liver disease. Forty-seven
patients (mean age, 44±10 years; 17 female) whose ALT levels had been high for at least 6 months and with hepatosteatosis
detected by liver biopsy and/or USG were enrolled in this study. Of these, 12 were treated with 850 mg/day metformin (group
1), 11 with 4 mg/day rosiglitazone (group 2), and 24 with diet and exercise (group 3) for 1 year. ALT normalization at months
6 and 12 was accepted as treatment response. Liver biopsy was performed in all patients in groups 1 and 2 before treatment
and 12 patients (4 in group 1, 8 in group 2) after treatment; but in group 3 it was performed only in patients who approved
this procedure (12 patients). Body mass index did not change in groups 1 and 2, but it decreased significantly in group 3
(30±3 to 28±2 kg/m2) at month 12. Treatment response rate was 33.3, 54.5, and 54.2% in groups 1, 2, and 3, respectively, at month 6. This rate
was 22.2, 37.5, and 41.2 in groups 1, 2, and 3, respectively, at month 12. Rate of steatosis and stage of fibrosis did not
change after treatment. Diet with exercise seems to be superior to metformin and rosiglitazone. Decreasing treatment response
at month 12 compared to month 6 may be due to fluctuations of ALT levels. Treatment response should be evalulated histologically. 相似文献
102.
Symptomatic interhemispheric arachnoid cysts (ACs) are extremely rare lesions seen more frequently in the elderly. Only 13 cases of symptomatic interhemispheric ACs in the elderly have previously been reported. Herein, we describe a 70-year-old female with symptoms of vertigo, memory and behavior disturbances. Magnetic resonance imaging (MRI) revealed a giant arachnoid cyst (AC) on the interhemispheric fissure, which was exerting a mass effect and displacement on the corpus callosum and anterior cerebral vessels, with a massive midline shift. The patient was treated with a cysto-peritoneal shunt. Reports to date have reviewed the pathology, clinical presentation, radiology and surgical management of interhemispheric symptomatic arachnoid cysts in elderly patients. 相似文献
103.
104.
Akyuz F Kaymakoglu S Demir K Aksoy N Karaca C Danalioglu A Onel D Badur S Besisik F Cakaloglu Y Okten A 《Acta gastro-enterologica Belgica》2007,70(1):20-24
BACKGROUND AND STUDY AIMS: To investigate the efficacy of the combined therapy of lamivudine (LAM) plus alpha interferon (IFN) and LAM monotherapy in HBeAg negative chronic hepatitis B (CHB) patients who were unresponsive to previous IFN monotherapy, and the incidence of YMDD mutations. PATIENTS-METHODS: Forty-five HBeAg negative patients were enrolled in this study. 24 of these were treated with LAM (100 mg/day, PO, for 24 months) alone (group 1) and 21 with combined therapy (IFN-alpha-2b, 10 MU, tiw, SC, for 6 months plus LAM 100 mg/day, PO, for 24 months) (group 2). Normal alanine aminotransferase values and negativity of HBV DNA (molecular hybridization; Digene, USA) were accepted as treatment response. YMDD variants were analyzed at the end of treatment or when clinical breakthrough was observed (Inno-Lipa Innogenetic kit, Belgium). RESULTS: End of follow-up response rate was 29.2%, by ITT in group 1, 19% in group 2 (p > 0.05). Histological activity index was statistically decreased by LAM monotherapy as compared to combination therapy. YMDD mutation rates were 59% in group 1, 62.5% in group 2 (p > 0.05). CONCLUSIONS: Additional IFN-alpha therapy to LAM in HBeAg negative CHB not responding to previous IFN-alpha monotherapy does not increase the response rate compared to LAM monotherapy and does not also decrease the incidence of YMDD mutations. 相似文献
105.
Dijke IE Caliskan K Korevaar SS Maat AP Zondervan PE Balk AH Weimar W Baan CC 《Transplant immunology》2008,18(3):250-254
Previously, we demonstrated in heart transplant patients that FOXP3, a gene required for the development and function of regulatory T cells, was highly expressed in the graft during an acute cellular rejection. In this study, we analyzed whether the FOXP3 gene expression in the peripheral blood also reflects anti-donor immune responses, and therefore may provide clues for non-invasive detection of non-responsiveness or acute rejection. We examined the FOXP3 expression patterns of peripheral blood mononuclear cells (PBMC; n=69) of 19 heart transplant patients during quiescence and rejection in comparison with those of endomyocardial biopsies (EMB; n=75) of 24 heart transplant patients. While the FOXP3 mRNA levels were abundantly expressed in rejecting EMB (ISHLT rejection grade>1R) compared with EMB without histological evidence of myocardial damage (ISHLT rejection grade 0R-1R; p=0.003), no association with rejection or non-responsiveness was found for the FOXP3 mRNA levels in the peripheral blood. Thus, in contrast to intragraft FOXP3 gene expression, the peripheral FOXP3 mRNA levels lack correlation with anti-donor immune responses in the graft, and, consequently, FOXP3 does not appear to be a potential candidate gene for non-invasive diagnosis of non-responsiveness or rejection. 相似文献
106.
107.
Kadir A Darreh-Shori T Almkvist O Wall A Långström B Nordberg A 《Psychopharmacology》2007,191(4):1005-1014
Rationale Marked reduction in the cortical nicotinic acetylcholine receptors is observed in the brain of patients suffering from Alzheimer’s
disease (AD). Although cholinesterase inhibitors are used for symptomatic treatment of mild to moderate AD patients, numerous
long-term treatment studies indicate that they might stabilize or halt the progression of the disease by restoring the central
cholinergic neurotransmission. Thus, we used positron emission tomography (PET) technique as a sensitive approach to assess
longitudinal changes in the nicotine binding sites in the brains of patients with AD.
Objective To evaluate changes in brain nicotinic binding sites in relation to inhibition level of cholinesterases in cerebrospinal fluid
(CSF) and plasma and changes in cognitive performance of the patients in different neuropsychological tests after rivastigmine
treatment.
Materials and methods Ten mild AD patients received rivastigmine for 12 months. A dual-tracer PET model with administration of 15O–water and (S)(–)11C–nicotine was used to assess 11C–nicotine binding sites in the brain at baseline and after 3 and 12 months of the treatment. Cholinesterase activities in
CSF and plasma were assessed colorimetrically.
Results The 11C–nicotine binding sites were significantly increased 12–19% in several cortical brain regions after 3 months compared with
baseline, while the increase was not significant after 12 months of the treatment. After 3 months treatment, low enzyme inhibition
in CSF and plasma was correlated with higher cortical 11C–nicotine binding. The 11C–nicotine binding positively correlated with attentional task at the 12-month follow-up.
Conclusion Changes in the 11C–nicotine binding during rivastigmine treatment might represent remodeling of the cholinergic and related neuronal network. 相似文献
108.
A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients 总被引:1,自引:0,他引:1
Hazneci E Karabulut AB Oztürk C Batçioğlu K Doğan G Karaca S Eşrefoğlu M 《International journal of dermatology》2005,44(8):636-640
BACKGROUND: Several groups have shown the involvement of oxidative stress in the pathophysiology of vitiligo. METHODS: In this study, we examined the erythrocyte and plasma activities of glutathione peroxidase and Cu/Zn superoxide dismutase, plasma nitrite/nitrate levels, and erythrocyte catalase activity in 23 vitiligo patients and 25 controls. RESULTS: The results show that erythrocyte superoxide dismutase activity and plasma nitrite/nitrate levels are high in vitiligo patients. CONCLUSIONS: Our study confirms that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of erythrocyte superoxide dismutase activity and plasma nitrite/nitrate. 相似文献
109.
Maurya Rajendra Prakash Singh Virendra Pratap Kadir Syeed Mehbub Ul Das Jayant Kumar Bosak Sanjay Kumar Prajapat Manish Kumar Roy Meghna Kushwaha Brijesh Kumar Kumar Anil Al-Mujaini Abdullah 《International ophthalmology》2022,42(4):1193-1203
International Ophthalmology - This study is aimed to determine the frequency, sociodemographic profile, clinical presentation, patterns of injury, treatment and outcomes of cases of... 相似文献
110.
Muhammed Selim BODUR Kadir TOMAS Serdar TOPALOLU ükrü OUZ Hakan KÜÜKASLAN Davut DOHMAN Erdem KARABULUT Adnan ALIK 《Turkish Journal of Medical Sciences》2021,51(3):1388
Background/aim Operative bleeding is one of the major determinants of outcome in liver surgery. This study aimed to describe the impact of intraoperative blood loss on the postoperative course of liver resection (LR). Materials and methods The data of 257 patients who were treated with LR between January 2007 and October 2018 were retrospectively analyzed. LRs were performed via intermittent portal triad clamping (PTC) under low central venous pressure. Results LRs were performed for 67.7% of patients with a malignant disease and 32.3% of patients with a benign disease. Major LR was performed in 89 patients (34.6%). The mean PTC period was 20.32 min (±13.7). The median intraoperative bleeding amount was 200 mL (5–3500 mL), the 30-day mortality rate was 4.3%, and the morbidity rate was 31.9%. The hospital stay (p = 0.002), morbidity (p = 0.009), and 30-day mortality (p = 0.041) of patients with a bleeding amount of more than 500 mL significantly increased. Conclusion Surgeons should consider the adverse effects of intraoperative bleeding during liver resection on patients’ outcome. Favorable outcomes would be obtained with diligent postoperative care. 相似文献