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排序方式: 共有6198条查询结果,搜索用时 281 毫秒
81.
82.
Hana Kim Jae-Pyo Jeon Chansik Hong Jinsung Kim Jongyoun Myeong Ju-Hong Jeon Insuk So 《Pflügers Archiv : European journal of physiology》2013,465(7):1011-1021
The transient receptor potential canonical 4 (TRPC4) channel is a Ca2+-permeable nonselective cation channel in mammalian cells and mediates a number of cellular functions. Many studies show that TRPC channels are activated by stimulation of Gαq-phospholipase C (PLC)-coupled receptors. However, our previous study showed that the TRPC4 current was inhibited by co-expression of a constitutively active form of Gαq (Gαq Q209L). A shortage of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] in Gαq Q209L may be responsible for reduced TRPC4 activity. Here, we tested this hypothesis by using a rapamycin-inducible system that regulates PI(4,5)P2 acutely and specifically. Our results showed that the TRPC4β current was reduced by inducible Gαq Q209L, but not by the mutants with impaired binding ability to PLCβ. Depletion of PI(4,5)P2 by inducing the inositol polyphosphate 5-phosphatase to HEK293 cells that express TRPC4β led to an irreversible inhibition of TRPC4β currents. In contrast, inducing phosphatidylinositol 4-phosphate 5-kinase or intracellular PI(4,5)P2 application did not activate the TRPC4β current. Finally, we revealed that PI(4,5)P2 is important in delaying the desensitization of TRPC4β. Taken together, we suggest that PI(4,5)P2 is not the activator of TRPC4β activation, but it is still necessary for regulating TRPC4β activation. 相似文献
83.
The extant empirical research examining the effectiveness of statistical and exemplar-based health information is largely inconsistent. Under the premise that the inconsistency may be due to an unacknowledged moderator (O’Keefe, 2002), this study examined a moderating role of outcome-relevant involvement (Johnson & Eagly, 1989) in the effects of statistical and exemplified risk information on risk perception. Consistent with predictions based on elaboration likelihood model (Petty & Cacioppo, 1984), findings from an experiment (N = 237) concerning alcohol consumption risks showed that statistical risk information predicted risk perceptions of individuals with high, rather than low, involvement, while exemplified risk information predicted risk perceptions of those with low, rather than high, involvement. Moreover, statistical risk information contributed to negative attitude toward drinking via increased risk perception only for highly involved individuals, while exemplified risk information influenced the attitude through the same mechanism only for individuals with low involvement. Theoretical and practical implications for health risk communication are discussed. 相似文献
84.
High risk of conversion to diabetes in first‐degree relatives of individuals with young‐onset type 2 diabetes: a 12‐year follow‐up analysis 下载免费PDF全文
85.
The purpose of this study was to investigate the relationship between weight status and recreational drug use in Korean adolescents.
A total of 72,399 adolescent students (38,152 boys and 34,247 girls) from the middle first to high third grade participated
in the 5th Korea Youth Risk Behaviour Web-based Survey (KYRBWS-V) project in 2009. They were assessed for body mass index (BMI) and
recreational drug abuse. The associations between BMI and recreational drug use were examined using multivariable logistic
regression analysis after adjusting for the covariate variables of age, smoking frequency and cigarette consumption, frequency
of alcohol consumption and severe alcohol intoxication, amount of alcohol consumed, parents’ education level, economic status,
sedentary activities during the week, mental stress, sleep duration, frequency of vigorous and moderate physical activities,
and muscular strength exercises during the week. For boys, the odds ratio (OR) (95% confidence interval [CI]) between overweight
and drug use were 0.990 (0.723–1.356; p = 0.950) for almost none, 0.939 (0.521–1.693; p = 0.834) for past use, and 0.791 (0.385–1.624;
p = 0.523) for present use. The OR (95% CI) between obesity and drug use was 0.731(0.508–1.052; p = 0.091) for almost none,
0.755 (0.389–1.465; p = 0.407) for past use, and 0.701 (0.314–1.565; p = 0.386) for present use. For girls, the OR (95% CI)
between overweight and drug use was 1.112 (0.702–1.763; p = 0.650) for almost none, 1.103 (0.464–2.619; p = 0.825) for past
use, and 0.927 (0.267–3.218; p = 0.905) for present use. The OR (95% CI) between obesity and drug abuse was 0.594 (0.261–1.352;
p = 0.215) for almost none, 1.318 (0.462–3.764; p = 606) for past use, and <0.001(<0.001–<0.001; p = 0.998) for present use.
We concluded that recreational drug use had no correlation with overweight and obesity in Korean adolescents. 相似文献
86.
87.
Kim Sung Jin Park Min Uk Chae Han Kyu Nam Wook Kim So Won Yu Hoon Kim Han Gwun Kang Gil Hyun Park Jong Yeon 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(2):403-410
International Journal of Clinical Oncology - Previous studies have shown a relationship between the occurrence and recurrence of prostate cancer; however, this relationship remains controversial.... 相似文献
88.
89.
Benjamin J. Lee Sheila K. Wang Chunkit So Brandon G. Chiu Wesley Y. Wang Radhika Polisetty Ana Qui?ones-Boex Hong Liu 《American journal of pharmaceutical education》2015,79(9)
Together with community advocates, professional student organizations can help improve access to health care and sustain services to address the health disparities of a community in need. This paper examines the health concerns of an underserved Chinese community and introduces a student-led health education initiative that fosters service learning and student leadership. The initiative was recognized by the American Association of Colleges of Pharmacy (AACP) and received the 2012-2013 Student Community Engaged Service Award. 相似文献
90.