全文获取类型
收费全文 | 1081167篇 |
免费 | 72072篇 |
国内免费 | 1375篇 |
专业分类
耳鼻咽喉 | 15094篇 |
儿科学 | 34820篇 |
妇产科学 | 28707篇 |
基础医学 | 154201篇 |
口腔科学 | 29620篇 |
临床医学 | 95646篇 |
内科学 | 204649篇 |
皮肤病学 | 24443篇 |
神经病学 | 82012篇 |
特种医学 | 43236篇 |
外国民族医学 | 201篇 |
外科学 | 163986篇 |
综合类 | 21864篇 |
现状与发展 | 2篇 |
一般理论 | 266篇 |
预防医学 | 75306篇 |
眼科学 | 24687篇 |
药学 | 86661篇 |
7篇 | |
中国医学 | 2834篇 |
肿瘤学 | 66372篇 |
出版年
2019年 | 7846篇 |
2018年 | 11392篇 |
2017年 | 9003篇 |
2016年 | 10171篇 |
2015年 | 11359篇 |
2014年 | 15418篇 |
2013年 | 22407篇 |
2012年 | 30869篇 |
2011年 | 32633篇 |
2010年 | 19163篇 |
2009年 | 18007篇 |
2008年 | 30271篇 |
2007年 | 32421篇 |
2006年 | 33001篇 |
2005年 | 31328篇 |
2004年 | 30019篇 |
2003年 | 28824篇 |
2002年 | 27792篇 |
2001年 | 60206篇 |
2000年 | 61643篇 |
1999年 | 51068篇 |
1998年 | 12514篇 |
1997年 | 11059篇 |
1996年 | 11074篇 |
1995年 | 10391篇 |
1994年 | 9384篇 |
1993年 | 8903篇 |
1992年 | 37934篇 |
1991年 | 36389篇 |
1990年 | 35853篇 |
1989年 | 34367篇 |
1988年 | 30950篇 |
1987年 | 30074篇 |
1986年 | 28287篇 |
1985年 | 26545篇 |
1984年 | 19269篇 |
1983年 | 16186篇 |
1982年 | 8863篇 |
1979年 | 17098篇 |
1978年 | 11447篇 |
1977年 | 10267篇 |
1976年 | 8861篇 |
1975年 | 10089篇 |
1974年 | 11693篇 |
1973年 | 11301篇 |
1972年 | 10782篇 |
1971年 | 10120篇 |
1970年 | 9279篇 |
1969年 | 8958篇 |
1968年 | 7946篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
901.
902.
903.
904.
A K Burroughs L Marelli E Cholongitas P Manousou K Rolles V Karam V Delvart R Adam C Sabin 《Liver transplantation》2007,13(6):935-6; author reply 937
905.
906.
907.
908.
909.
Y Imamura K Yanagihara Y Fukuda Y Kaneko M Seki K Izumikawa Y Miyazaki Y Hirakata T Sawa J P Wiener-Kronish S Kohno 《The European respiratory journal》2007,29(5):965-968
Pseudomonas aeruginosa is one of the most important pathogens in patients with chronic airway conditions, such as cystic fibrosis and diffuse panbronchiolitis. Type III secretion system-mediated virulence factors contribute to the lung damage in chronic P. aeruginosa infection. The effects of the anti-PcrV immunoglobulin (Ig)G, which blocks the type III secretion system, were evaluated in a mouse model of chronic P. aeruginosa infection. On bacteriological examination, anti-PcrV IgG showed no bactericidal effects. On bronchoalveolar lavage fluid (BALF) analysis, total cell number and neutrophil ratios in the anti-PcrV IgG-treated groups were lower than those in the control group. In addition, macrophage inflammatory protein-2, tumour necrosis factor-alpha, and interleukin-beta concentrations in BALF were lower in the anti-PcrV IgG-treated groups when compared with controls. Plasma anti-PcrV IgG titre was elevated after administration of anti-PcrV IgG. Although plasma titre decreased gradually, a significant concentration was maintained during the experimental period. These data suggest that anti-PcrV immunoglobulin G reduces the inflammatory reaction caused by chronic Pseudomonas aeruginosa respiratory infection and may be useful in treating respiratory diseases. 相似文献
910.
J C Ho M Chan-Yeung S P Ho J C Mak M S Ip G C Ooi M P Wong K W Tsang W K Lam 《The European respiratory journal》2007,29(2):273-278
The present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry. In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48.7 (27.0-64.3) U x (ghaemoglobulin(Hb)(-1)), and higher GPx activity (175.2 (126.6-288.3) versus 49.2 (39.5-59.2) mU x (gHb)(-1)) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities. In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. 相似文献