全文获取类型
收费全文 | 28780篇 |
免费 | 2069篇 |
国内免费 | 312篇 |
专业分类
耳鼻咽喉 | 537篇 |
儿科学 | 389篇 |
妇产科学 | 401篇 |
基础医学 | 4634篇 |
口腔科学 | 861篇 |
临床医学 | 2984篇 |
内科学 | 5511篇 |
皮肤病学 | 1044篇 |
神经病学 | 2128篇 |
特种医学 | 1746篇 |
外科学 | 3495篇 |
综合类 | 163篇 |
现状与发展 | 3篇 |
一般理论 | 8篇 |
预防医学 | 1142篇 |
眼科学 | 502篇 |
药学 | 2683篇 |
中国医学 | 426篇 |
肿瘤学 | 2504篇 |
出版年
2023年 | 157篇 |
2022年 | 543篇 |
2021年 | 1090篇 |
2020年 | 591篇 |
2019年 | 810篇 |
2018年 | 957篇 |
2017年 | 754篇 |
2016年 | 1109篇 |
2015年 | 1517篇 |
2014年 | 1590篇 |
2013年 | 1914篇 |
2012年 | 2706篇 |
2011年 | 2499篇 |
2010年 | 1542篇 |
2009年 | 1224篇 |
2008年 | 1672篇 |
2007年 | 1484篇 |
2006年 | 1269篇 |
2005年 | 1192篇 |
2004年 | 960篇 |
2003年 | 847篇 |
2002年 | 703篇 |
2001年 | 443篇 |
2000年 | 415篇 |
1999年 | 348篇 |
1998年 | 235篇 |
1997年 | 211篇 |
1996年 | 165篇 |
1995年 | 134篇 |
1994年 | 121篇 |
1993年 | 120篇 |
1992年 | 131篇 |
1991年 | 156篇 |
1990年 | 138篇 |
1989年 | 119篇 |
1988年 | 124篇 |
1987年 | 87篇 |
1986年 | 92篇 |
1985年 | 74篇 |
1984年 | 55篇 |
1983年 | 45篇 |
1982年 | 35篇 |
1979年 | 59篇 |
1978年 | 41篇 |
1975年 | 53篇 |
1974年 | 30篇 |
1972年 | 39篇 |
1971年 | 51篇 |
1970年 | 35篇 |
1968年 | 31篇 |
排序方式: 共有10000条查询结果,搜索用时 593 毫秒
991.
Hye Na Jung Jung Hee Shin Boo-Kyung Han Eun Young Ko Eun Yoon Cho 《Breast (Edinburgh, Scotland)》2013,22(3):324-329
The aim of this study was to evaluate whether pleomorphic invasive lobular carcinoma (PILC) is different from classic invasive lobular carcinoma (CILC) in terms of radiologic and clinicopathologic features.We compared the radiologic and clinicopathologic features of 22 surgically confirmed PILCs in 21 patients from 2004 to 2009 and 47 CILCs from 47 consecutive patients. For all cases, we reviewed the imaging findings, medical records and pathological results.PILC had a higher T stage, N stage, nuclear and histologic grade compared to CILC. PILC was more commonly negative for estrogen receptors and positive for HER2 than CILC (all p < 0.05). However, there were no significant differences in age, symptoms, tumor size, extensive intraductal component, lymphovascular invasion, triple negative profile, or multiplicity between the two groups. PILC was not detected on mammography in 1 (4.5%) of 22 cases, whereas CILC was not detected on mammography in 7 (14.9%) of 47 cases and on MRI in 2 (5.0%) of 40 (p = 0.42 and p = 1.000, respectively). MRI identified more frequent multiplicity than mammography for both PILC and CILC (p < 0.001), but was similar to US (p = 0.066). Most lesions showed a spiculated mass or architectural distortion with or without calcifications on mammography and ultrasound. No differences in mass and/or non-mass lesions or kinetics on MRI were observed between the two groups.PILC shows more pathologically aggressive features, but cannot be differentiated from CILC based on imaging findings. 相似文献
992.
Ju‐Hyung Lee Lu Zhou Keun‐Sang Kwon Dongwook Lee Byung‐Hyun Park Jung Ryul Kim 《Journal of orthopaedic research》2013,31(10):1605-1610
Obesity is considered a clinical risk sign for Legg–Calvé–Perthes disease (LCPD). Leptin is primarily secreted by adipocytes, and it regulates adipose tissue mass and body weight. Furthermore, obesity is clearly associated with increased leptin levels. We investigated the roles of leptin and the soluble leptin receptor (sOB‐R) in LCPD. This matched case–control study included 38 male and 3 female patients with LCPD, and an equal number of age—(range was 4–12) and sex‐matched control patients with healthy fractures. Serum leptin and sOB‐R levels were quantified with ELISA. The free leptin index (FLI) was defined as the ratio of leptin to sOB‐R levels. Serum leptin levels, sOB‐R, and FLI were compared between groups. The relationship between leptin, disease severity, and treatment outcomes were analyzed in the LCPD group. There were no significant differences between groups in terms of age, sex, and body mass index (BMI) percentile. Mean leptin levels (p = 0.042), sOB‐R levels (p = 0.003), and FLI (p = 0.013) differed significantly between groups. In the LCPD group, the serum leptin levels, sOB‐R levels, and FLI differed significantly between the lateral pillar and Stulberg classification groups (p < 0.05). Also, the leptin levels and FLI increased significantly according to the lateral pillar and Stulberg classifications even after adjusting for age and BMI percentile (p < 0.05). Circulating leptin and FLI were significantly higher in the LCPD group. Furthermore, leptin, disease severity, and treatment outcomes were associated. This correlation suggests that leptin might play an important role in LCPD pathogenesis. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1605‐1610, 2013 相似文献
993.
994.
Jay R Shapiro Caressa Lietman Monica Grover James T Lu Sandesh CS Nagamani Brian C Dawson Dustin M Baldridge Matthew N Bainbridge Dan H Cohn Maria Blazo Timothy T Roberts Feng‐Shu Brennen Yimei Wu Richard A Gibbs Pamela Melvin Philippe M Campeau Brendan H Lee 《Journal of bone and mineral research》2013,28(7):1523-1530
995.
996.
Hyo Jin Kim Hyunsuk Kim Hyun Seop Cho Jin Ho Hwang In Mok Jung Curie Ahn Jongwon Ha Yun Kyu Oh Chun Soo Lim Dong‐Wan Chae Yon Su Kim Jung Pyo Lee 《Clinical transplantation》2013,27(6):866-874
The etiology of renal disease is important because the primary renal pathology may affect the outcomes of kidney allograft with respect to recurrence, rejection, and survival. However, for a significant number of patients who undergo kidney transplantation, the disease etiology is unknown. Here, allograft outcomes for patients with kidney disease of unknown etiology (UEK) at three affiliated Korean hospitals were identified. The incidence of biopsy‐proven acute rejection (BPAR) for UEK was 22.9%, which was similar to the rates for diabetic nephropathy (DN, 24.4%) and IgA nephropathy (IgAN, 20.0%; p = 0.345). The cumulative incidence of post‐transplant glomerulonephritis (PTGN) among patients with UEK was significantly lower than that among patients with IgAN (p < 0.001). Overall graft survival of the UEK group was superior to that of the DN group (hazards ratio 0.39, 95% confidence interval 0.17–0.92, p = 0.030). Preemptive transplantation for UEK significantly reduced the incidence of BPAR (preemptive vs. non‐preemptive 9.6% vs. 30.3%, p = 0.001), but graft survival and recurrence were not affected by preemptive transplantation. The outcomes of kidney transplantation for patients with UEK were not inferior to those for patients with IgAN or DN. Preemptive kidney transplantation may be encouraged for UEK patients. 相似文献
997.
Sang Hyun Lee Mi Sook Gwak Soo Joo Choi Young Hee Shin Justin Sangwook Ko Gaab Soo Kim Suk Young Lee Myung Hee Kim Hui Gyeong Park Suk‐Koo Lee Hee Jung Jeon 《Clinical transplantation》2013,27(2):E126-E136
Although many report intra‐operative cardiac arrests (ICAs) in liver transplantation (LT), the incidence, major causes, and outcome remain unclear. We aimed to investigate retrospectively, the incidence, nature, and outcome of ICA in Asian population and to identify risk factors for ICA. Consecutive 1071 LTs in an institution during 1996–2011 (adult 920, pediatric 151/living donor liver transplantation, LDLT 841, deceased donor liver transplantation, DDLT 230) were reviewed. ICA occurred in 14 adult LTs (1.5%), but none in pediatrics. ICA occurred 1.0% and 3.3% in LDLT and DDLT, respectively. Stages of ICA incidence were three at pre‐anhepatic, one at anhepatic, and 10 at neohepatic stage. Post‐reperfusion syndrome (PRS) with hyperkalemia and bleeding were the major causes of ICA. While LDLT showed miscellaneous causes for ICA at various stages, DDLT incurred ICAs at neohepatic stage only. Interestingly, we did not find pulmonary thromboembolism (PTE) to incur ICA. Risk factor analysis showed no association of pre‐operative patient condition, donor types, and intra‐operative parameters. In this review, the incidence of ICA was low in Asian population with LDLT predominance, and while PTE was not the cause of ICA, the neohepatic stage with PRS and bleeding was the most vulnerable period to anticipate ICA. 相似文献
998.
Minki Baek Jung Yoon Kang Jeongyun Jeong Dae Kyung Kim Kwang Myung Kim 《International urology and nephrology》2013,45(3):703-709
Purpose
We investigated the treatment outcomes according to neuropathic bladder sphincter dysfunction (NBSD) type after oral oxybutynin (OBT) treatment in children with NBSD caused by myelodysplasia.Methods
Among 334 pediatric patients who were diagnosed with NBSD caused by myelodysplasia, only children treated with oral OBT for more than 1 year with pre- and post-treatment urodynamic studies and dimercaptosuccinic acid (DMSA) were retrospectively reviewed. We compared pre- and post-treatment urodynamic parameters including maximum cystometric capacity (MCC), MCC/estimated bladder capacity (EBC), and compliance by NBSD type in children. We also compared renal scarring on pre- and post-treatment DMSA by NBSD type in children.Results
Our study population was comprised of 81 children (45 boys and 36 girls), with a mean age of 4.2 ± 3.4 years. The mean follow-up duration was 4.5 (range 1.0–15.1) years. After OBT treatment, MCC was increased significantly in all types of NBSD from 110.3 ± 62.2 to 202.3 ± 103.9 ml (p < 0.05), compliance was significantly improved from 6.4 ± 6.1 to 11.1 ± 9.6 ml/cmH2O (p < 0.05), but MCC/EBC was slightly decreased from 75.2 ± 46.9 to 69.8 ± 33.3 % (p = 0.40). Sub-analyzed by NBSD type, the pre-treatment compliance of children with acontractile detrusor with spastic sphincter (n = 16) was markedly decreased compared with other types of NBSD. Acontractile detrusor with spastic sphincter demonstrated the worst renal deterioration on DMSA.Conclusions
Although increases in MCC/EBC were limited, oral OBT treatment markedly improved MCC and compliance in all NBSD types. Children who had acontractile detrusor with spastic sphincter had a relatively high probability of renal deterioration and required specific attention. 相似文献999.
Insang Hwang Sun-Ouck Kim Ho-Song Yu Eu-Chang Hwang Seung-Il Jung Taek-Won Kang Dongdeuk Kwon Kwangsung Park 《International urology and nephrology》2013,45(3):639-643
Background and purpose
To determine landmarks for stent positioning in both ureteral orifices (UOs) and the gender differences in their location in men and women.Patients and methods
The location of the UO and the bladder neck (BN) was measured fluoroscopically by the intravesical distal location of an open-ended catheter marked with radiopaque materials. We compared the location in men (n = 12) and women (n = 12) with a full bladder (hydrostatic pressure of 50 cmH2O) or an empty bladder.Results
The mean distances from BN to UO in men and women were significantly different both in an empty bladder (2.5 ± 0.4 and 2.1 ± 0.3 cm, respectively) and in a full bladder (2.9 ± 1.0 and 2.3 ± 0.6 cm, respectively). The location of UO was changed by bladder filling in women but not in men. In women, most UOs were found superior to the symphysis pubis (SP) in empty bladder (66.6 %). Most of this location was observed at behind the upper boarder of SP in full bladder of women (75 %). The BN of women was located at the lower level in basal state compared to men. Also, the location of BN was markedly changed by bladder fulling in women (p = 0.04) but not in men.Conclusions
Significant gender differences were observed in the location of UO and BN. Clinicians should keep in mind the anatomical differences between men and women during fluoroscopic-guided procedure. 相似文献1000.
Dong Hyun Kim Sung Hoon Kim Gi Hong Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Woo Jung Lee 《World journal of surgery》2013,37(11):2635-2640