全文获取类型
收费全文 | 69976篇 |
免费 | 6770篇 |
国内免费 | 110篇 |
专业分类
耳鼻咽喉 | 508篇 |
儿科学 | 2152篇 |
妇产科学 | 1479篇 |
基础医学 | 9507篇 |
口腔科学 | 1469篇 |
临床医学 | 9434篇 |
内科学 | 13231篇 |
皮肤病学 | 1179篇 |
神经病学 | 6169篇 |
特种医学 | 2266篇 |
外国民族医学 | 1篇 |
外科学 | 8533篇 |
综合类 | 1359篇 |
一般理论 | 66篇 |
预防医学 | 8597篇 |
眼科学 | 1241篇 |
药学 | 5283篇 |
中国医学 | 96篇 |
肿瘤学 | 4286篇 |
出版年
2023年 | 375篇 |
2022年 | 637篇 |
2021年 | 1346篇 |
2020年 | 915篇 |
2019年 | 1378篇 |
2018年 | 1611篇 |
2017年 | 1171篇 |
2016年 | 1273篇 |
2015年 | 1390篇 |
2014年 | 1940篇 |
2013年 | 2820篇 |
2012年 | 4153篇 |
2011年 | 4246篇 |
2010年 | 2313篇 |
2009年 | 2133篇 |
2008年 | 3645篇 |
2007年 | 3838篇 |
2006年 | 3642篇 |
2005年 | 3432篇 |
2004年 | 3134篇 |
2003年 | 2890篇 |
2002年 | 2836篇 |
2001年 | 1656篇 |
2000年 | 1578篇 |
1999年 | 1596篇 |
1998年 | 794篇 |
1997年 | 629篇 |
1996年 | 595篇 |
1995年 | 583篇 |
1994年 | 526篇 |
1993年 | 559篇 |
1992年 | 1254篇 |
1991年 | 1164篇 |
1990年 | 1104篇 |
1989年 | 1066篇 |
1988年 | 982篇 |
1987年 | 982篇 |
1986年 | 998篇 |
1985年 | 914篇 |
1984年 | 799篇 |
1983年 | 647篇 |
1982年 | 451篇 |
1981年 | 367篇 |
1979年 | 599篇 |
1978年 | 491篇 |
1977年 | 379篇 |
1976年 | 393篇 |
1974年 | 440篇 |
1973年 | 407篇 |
1972年 | 390篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
Ehab Farag Maged Argalious Samer Narouze Glenn E. DeBoer Julie Tome 《Journal canadien d'anesthésie》2002,49(9):958-962
PURPOSE: To present the anesthetic management for the correction of a ventricular septal defect (VSD) in a patient with multiple acyl CoA dehydrogenase deficiency (glutaric aciduria type II; GAII). A review of the literature about anesthetic management of patients with mitochondrial diseases undergoing cardiopulmonary bypass (CPB) is also included. Clinical features: An 11-yr-old girl with GAII manifested as severe hypoglycemia since she was a newborn and generalized muscle weakness. She underwent open-heart surgery for VSD correction with CPB. The anesthetic management avoided inhalational anesthetics, maintained the blood sugar within normal limits and continued normothermia during CPB in order to avoid the stress of hypothermia for her abnormal mitochondria. The patient tolerated the procedure well and experienced a good recovery. CONCLUSION: The anesthetic management of patients with any mitochondrial disease requires normoglycemia, normothermia and the avoidance of metabolic stress in order to preserve energy production by the diseased mitochondria. 相似文献
22.
Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trial 总被引:1,自引:1,他引:0 下载免费PDF全文
23.
Ronald Martin Jaime Williams Thomas Hadjistavropoulos Heather D Hadjistavropoulos Michael MacLean 《Revue canadienne de recherche en sciences infirmières》2005,37(2):142-164
The literature suggests that pain in the elderly, especially among seniors with dementia, is under-assessed and under-treated.This qualitative study solicited the perspectives of seniors, front-line nursing staff, nursing-home administrators, and informal caregivers of seniors with dementia on the current status of pain assessment and management. The views of these participants complement the research findings reported in the literature. While some of their explanations and potential solutions concerning under-treatment of pain in seniors echo views that have been presented in the literature, the participants also pointed to factors and avenues that have been given less formal consideration (e.g., systemic barriers to effective assessment and treatment of pain).They also highlighted the need for pain-control strategies beyond medication. The implications of these findings are discussed. 相似文献
24.
25.
26.
Julie M Aultman 《Medical education》2009,43(11):1107-1107
27.
M P McMurry P N Hopkins R Gould K Engelbert-Fenton C Schumacher L L Wu R R Williams 《Journal of the American Dietetic Association》1991,91(1):57-65
We have developed a unique, family-oriented approach to lowering plasma cholesterol concentrations in persons with familial hyperlipidemias. The approach includes individual clinic visits and group nutrition classes and uses dietary goals outlined in The New American Diet. A series of 13 nutrition classes is presented to small groups, usually composed of relatives from pedigrees with familial hypercholesterolemia or other familial hyperlipidemias. Dietary action goals, cooking demonstrations, food tasting, and finger-stick plasma cholesterol determinations are important components of the classes. Problem-solving discussion is encouraged in the group. Over the past 4 years, 143 hyperlipidemic individuals, along with at least 94 unaffected family members, have participated in 31 groups, which have met for at least six classes. Many clinic participants lower plasma cholesterol by 20% or more. Keys to the success of this program include emphasizing dietary therapy, using the family setting for nutrition intervention, providing hands-on experience with food and recipes, promoting problem solving for dietary action goals, measuring blood cholesterol during classes, and encouraging long-term follow-up for participants with physicians and dietitians. 相似文献
28.
In 1984, in addition to its standard traditional curriculum, Rush Medical College (Chicago, Ill) developed a Socratic problem-based method of teaching basic science material called the alternative curriculum. As part of an evaluation of this new curriculum, students in the two curricula were compared using three traditional measurements: (1) test scores from the National Board of Medical Examiners, Part I; (2) test scores from the National Board of Medical Examiners, Part II; and (3) performance on an oral examination. Alternative curriculum students did not differ significantly from their traditional curriculum classmates on National Board of Medical Examiners, Part I and Part II total scores, although their subset scores on Part I did tend to be lower, reaching significance in one subset area. Differences in performance favoring the traditional curriculum were primarily seen in the early years of the program. Alternative curriculum students in the class matriculated in 1987 scored significantly higher in three of five categories on the oral examination. 相似文献
29.
30.
Bill J Gurley Ashley Swain Gary W Barone D Keith Williams Philip Breen C Ryan Yates Leslie B Stuart Martha A Hubbard Yudong Tong Sreekhar Cheboyina 《Drug metabolism and disposition》2007,35(2):240-245
Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters may give rise to many herb-drug interactions. Serial plasma concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with goldenseal or kava kava modified P-gp activity in vivo. Twenty healthy volunteers were randomly assigned to receive a standardized goldenseal (3210 mg daily) or kava kava (1227 mg daily) supplement for 14 days, followed by a 30-day washout period. Subjects were also randomized to receive rifampin (600 mg daily, 7 days) and clarithromycin (1000 mg daily, 7 days) as positive controls for P-gp induction and inhibition, respectively. Digoxin (Lanoxin, 0.5 mg) was administered p.o. before and at the end of each supplementation and control period. Serial digoxin plasma concentrations were obtained over 24 h and analyzed by chemiluminescent immunoassay. Comparisons of area under the curve (AUC)((0-3)), AUC((0-24)), C(max,) CL/F, and elimination half-life were used to assess the effects of goldenseal, kava kava, rifampin, and clarithromycin on digoxin pharmacokinetics. Rifampin produced significant reductions (p < 0.01) in AUC((0-3)), AUC((0-24)), CL/F, t(1/2), and C(max), whereas clarithromycin increased these parameters significantly (p < 0.01). With the exception of goldenseal's effect on C(max) (14% increase), no statistically significant effects on digoxin pharmacokinetics were observed following supplementation with either goldenseal or kava kava. When compared with rifampin and clarithromycin, supplementation with these specific formulations of goldenseal or kava kava did not appear to affect digoxin pharmacokinetics, suggesting that these supplements are not potent modulators of P-gp in vivo. 相似文献