全文获取类型
收费全文 | 615篇 |
免费 | 33篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 26篇 |
妇产科学 | 37篇 |
基础医学 | 56篇 |
口腔科学 | 27篇 |
临床医学 | 94篇 |
内科学 | 113篇 |
皮肤病学 | 4篇 |
神经病学 | 35篇 |
特种医学 | 43篇 |
外科学 | 100篇 |
综合类 | 25篇 |
预防医学 | 28篇 |
眼科学 | 6篇 |
药学 | 51篇 |
中国医学 | 3篇 |
肿瘤学 | 39篇 |
出版年
2024年 | 2篇 |
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 20篇 |
2017年 | 8篇 |
2016年 | 7篇 |
2015年 | 16篇 |
2014年 | 28篇 |
2013年 | 36篇 |
2012年 | 28篇 |
2011年 | 32篇 |
2010年 | 29篇 |
2009年 | 23篇 |
2008年 | 17篇 |
2007年 | 54篇 |
2006年 | 32篇 |
2005年 | 38篇 |
2004年 | 46篇 |
2003年 | 29篇 |
2002年 | 26篇 |
2001年 | 17篇 |
2000年 | 18篇 |
1999年 | 14篇 |
1998年 | 9篇 |
1997年 | 13篇 |
1996年 | 5篇 |
1995年 | 17篇 |
1994年 | 5篇 |
1993年 | 11篇 |
1992年 | 10篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1989年 | 17篇 |
1988年 | 7篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有689条查询结果,搜索用时 15 毫秒
571.
Although catatonia is a well defined syndrome, the treatment of chronic catatonia remains an unresolved issue. Here, we report a successful treatment of a 30-year-old patient with treatment-resistant catatonic schizophrenia in 10 years by augmentation of selective serotonin reuptake inhibitors (SSRIs).We present a 30-year-old man with treatment-resistant catatonic schizophrenia who failed to respond to the treatment of benzodiazepines and antipsychotics for 10 years. He markedly improved after taking SSRIs. Now, he does not hold odd postures and begins to talk and show more facial expressions.We postulate that the therapeutic effect is related to the enhancement of 5-HT neurotransmission. SSRIs can be a considerable choice to treat chronic catatonia. 相似文献
572.
Middle‐term results of trans‐catheter creation of atrial communication in patients receiving mechanical circulatory support
下载免费PDF全文
![点击此处可从《Catheterization and cardiovascular interventions》网站下载免费的PDF全文](/ch/ext_images/free.gif)
573.
BACKGROUND: The circulating levels of adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), have been demonstrated to be elevated in patients with rheumatic mitral stenosis (MS). However, the impact of percutaneous transluminal mitral valvuloplasty (PTMV) on the elevated circulating levels of VCAM-1 and ICAM-1 in patients with MS has never been investigated. METHODS: and results: A total of 19 patients with symptomatic MS undergoing PTMV were studied (group 1) [15 patients in chronic atrial fibrillation, and 4 patients in sinus rhythm]. The plasma levels of soluble VCAM-1 and ICAM-1 in the femoral vein and artery, and right and left atria before PTMV, and those in the peripheral venous blood at the 1-week and 4-week follow-ups after PTMV were determined by solid-phase sandwich enzyme-linked immunosorbent assay. The mitral valve area was calculated by means of the Doppler pressure half-time method. In addition, we measured plasma concentrations of soluble VCAM-1 and ICAM-1 in the peripheral venous blood samples obtained from 22 control patients (including 14 healthy volunteers in sinus rhythm [group 2] and 8 patients in chronic lone atrial fibrillation [group 3]). The plasma level of soluble VCAM-1 was significantly elevated in group 1 patients (1,205.4 +/- 462.4 ng/mL [mean +/- SD]) compared with group 2 (580.9 +/- 208.0 ng/mL) and group 3 patients (716.4 +/- 221.6 ng/mL) [p < 0.0001]. In group 1 patients, the plasma levels of soluble VCAM-1 and ICAM-1 in the left atrium did not differ from those in the right atrium, femoral vein, or femoral artery (p = 0.668 for VCAM-1, and p = 0.232 for ICAM-1). The area of mitral valve increased significantly after PTMV (1.08 +/- 0.14 cm(2) vs 1.48 +/- 0.33 cm(2), p < 0.0001). The mean left atrial pressure fell significantly after PTMV (22.9 +/- 5.2 mm Hg vs 17.7 +/- 6.0 mm Hg, p < 0.0001). The peripheral venous plasma level of soluble VCAM-1 obtained before PTMV fell significantly after PTMV (before, 1,205.4 +/- 462.4 ng/mL; 1 week after PTMV, 915.7 +/- 280.2 ng/mL; 4 weeks after PTMV, 859.0 +/- 298.7 ng/mL; p < 0.0001). CONCLUSIONS: In patients with moderate-to-severe MS, the venous plasma level of soluble VCAM-1 fell significantly after PTMV, and the elevated plasma soluble VCAM-1 concentration was associated with hemodynamic abnormality rather than with rheumatic activity. 相似文献
574.
575.
Yanfang Li Menda LP Qiuliang WU Fuyuan Liu Jundong Li Jinglin Zou Yongwen Huang 《中国肿瘤临床(英文版)》1996,1(3):180-184
Objective Ovarian dysgerminoma is an uncommon ovarian malignancy, Its clinicai features are special and there are many factors affecting
its prognosis. If treated properly, the patient can be cured. Otherwise it may endanger the patient’s life. The aim of this
study is to investigate the clinical features and factors related to prognosis of ovarian dysgerminoma.
Methods Data from 57 patients with pure ovarian dysgerminoma were analyzed retrospectively. The patients were admitted to the Cancer
Center, Sun Yat-sen University from January 1.1964 to December 31, 2000.
Results The main clinical features were abdominal mass (56.1% ), abdominal pain (21.1% ), abdominal swelling (17.5%.), vaginal bleeding
(5.3% )and genital tract abnormalities (5.3%). Twenty-six patients had stage I diseases, 8 stage II.9 stage III.1 stage IV
and 13 recurrent and persistent diseases. The uterus was involved in 41.2% of patients with stage II -III diseases. Combined
modality was given to 52 cases and a single-method treatment to 5 cases. The total overall 5 and 10-year survival rates for
stages I-IV was 80.1 % and 70.0% respectively. The 5-year survival rate for stage I was 100%, stage II 55.2%. stage III 55.6%
and stage IV 0%; for recurrent and persistent diseases, 72.7%. The stage I group of 12 patients. received adnexectomy and
14 patients underwent hysterectomy and adnexa removal. There was no significant difference between the 5 and 10-year survival
rates (all 100%). Of the 23 patients in the stage I group to whom oniy chemotherapy was given after operation, 19 cases received
3 or more courses and were well without recurrence; 4 patients received only one course and one of them recurred 21 months
after the operation. In the group of stages II and III cases, the 5-year survival rate was 86.7% for those whose chemotherapy
courses were 3≥ 4 and 25.0% for patients who received less than 4 courses of chemotherapy (P<0.05).
Conclusions The prognosis of ovarian dysgerminoma is closely related to the disease stage and treatment modality. A fertility-preserving
operation can be considered in early -staged patients, but caution needs to be exercised in the middle to late staged cases.
Good results can be achieved with an operation-based combined modality in recurrent patients. 相似文献
576.
577.
JP Shield LP Hunt F Karachaliou K Karavanaki JD Baum 《Archives of disease in childhood》1995,73(6):512-514
In 1990, 81 children and adolescents with insulin dependent diabetes were studied for early signs of diabetic nephropathy. Nine patients were identified as having microalbuminuria (incipient nephropathy). These subjects were re-examined three years later. In five of these cases, the second examination revealed normal albumin excretion; in three of the four cases in whom microalbuminuria persisted, the rate of albumin excretion had decreased. The general improvement in albumin excretion rates in the initially microalbuminuric group could not be explained by improved glycaemic control nor interventional drug treatment. The lack of progression in this microalbuminuric group from the original prevalence study suggests that this method of identifying early nephropathy in childhood may not be valid or that the progression of incipient nephropathy in childhood is more irregular or slower than in later life. 相似文献
578.
Norplant皮下埋植剂长期使用的有效性临床研究—八年经验 总被引:10,自引:8,他引:10
上海医科大学妇产科医院于1984年10月至1993年12月应用Norplant皮下埋植剂1657例(其中Norplant—Ⅰ型1356例,Norplant-Ⅱ301例)控制生育。1、3、5、6、7、8年的累积妊娠率分别为0、0.1、0.9、1.7、2.6、和3.3/100妇女;妊娠率与最初埋植时的体重有关,体重重者妊娠率高。持续使用率分别为97.1、82.2、73.5、44.7、34.3和18.5/100妇女。主要副反应为月经失调,是终止使用的主要原因;但总失血量不多,随着使用时间的延长,月经失调副反应逐渐减少。埋植剂的放置和取出技术易于掌握,在1657例使用中,未发生感染或其他并发症,使用安全。由于其妊娠率低,和不可能脱落及其高度可逆性,深为受术者欢迎。 相似文献
579.
目的 探讨ICU患者锁骨下静脉穿刺置管术(SVC)的操作及并发症发生情况.方法 回顾性分析2007年1 月至2011年12月接受SVC的257例ICU患者的临床资料.结果 穿刺成功率为98.1%,其中一次穿刺成功211例,重复穿刺成功41例,因患者血管变异或操作技术原因导致失败5例.并发症发生率12.1%,总计31例,其中导管尖端入颈内静脉12例,导管相关感染8例,皮下血肿6例,气胸3例,心律失常2例.结论 SVC成功率高,操作步骤易于掌握,对患者颈部及四肢活动影响小,导管保留时间较长,方便护理,感染概率低于颈内、股静脉置管. 相似文献
580.
Gastrointestinal enhancement of MRI with melanin derived from tea leaves (Thea sinensis Linn.). 总被引:1,自引:0,他引:1
Yao Ching Hung Vasyl M Sava Chi Long Juang Tzu chen Yeh Wu Chung Shen Guewha Steven Huang 《Journal of ethnopharmacology》2002,79(1):75-79
Melanin was extracted from tea leaves (Thea sinensis Linn.) for the first time. Characterization of melanin proved similarity of the original compound to standard melanin. The Langmuir adsorption isotherms for gadolinium (Gd) binding were obtained using melanin. Melanin-Gd preparation demonstrated low acute toxicity. LD(50) for this preparation was in a range of 1250-1500 mg/kg in mice. Magnetic Resonance Imaging (MRI) properties of melanin itself and melanin-Gd complexes have been estimated. Gd free melanin fractions possess slighter relaxivity compared with its complexes. The relaxivity of lower molecular weight fraction was two times higher than relaxivity of Gd(DTPA) standard. Postcontrast images demonstrate that oral administration of melanin complexes in concentration 0.1 mM provides essential enhancement to longitudinal relaxation times (T(1))-weighted spin echo image. The required contrast and delineation of the stomach wall demonstrated uniform enhancement of MRI with proposed melanin complex. 相似文献