全文获取类型
收费全文 | 1695篇 |
免费 | 117篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 24篇 |
妇产科学 | 49篇 |
基础医学 | 217篇 |
口腔科学 | 9篇 |
临床医学 | 158篇 |
内科学 | 393篇 |
皮肤病学 | 18篇 |
神经病学 | 309篇 |
特种医学 | 25篇 |
外科学 | 169篇 |
综合类 | 5篇 |
一般理论 | 1篇 |
预防医学 | 116篇 |
眼科学 | 34篇 |
药学 | 81篇 |
中国医学 | 3篇 |
肿瘤学 | 200篇 |
出版年
2022年 | 20篇 |
2021年 | 45篇 |
2020年 | 13篇 |
2019年 | 23篇 |
2018年 | 41篇 |
2017年 | 31篇 |
2016年 | 29篇 |
2015年 | 37篇 |
2014年 | 53篇 |
2013年 | 57篇 |
2012年 | 83篇 |
2011年 | 112篇 |
2010年 | 51篇 |
2009年 | 66篇 |
2008年 | 89篇 |
2007年 | 92篇 |
2006年 | 90篇 |
2005年 | 70篇 |
2004年 | 57篇 |
2003年 | 77篇 |
2002年 | 71篇 |
2001年 | 36篇 |
2000年 | 22篇 |
1999年 | 34篇 |
1998年 | 15篇 |
1997年 | 15篇 |
1996年 | 13篇 |
1994年 | 15篇 |
1993年 | 18篇 |
1992年 | 23篇 |
1991年 | 26篇 |
1990年 | 29篇 |
1989年 | 21篇 |
1988年 | 22篇 |
1987年 | 28篇 |
1986年 | 24篇 |
1985年 | 18篇 |
1984年 | 13篇 |
1983年 | 18篇 |
1981年 | 12篇 |
1979年 | 17篇 |
1978年 | 12篇 |
1976年 | 17篇 |
1975年 | 11篇 |
1974年 | 13篇 |
1973年 | 11篇 |
1972年 | 12篇 |
1971年 | 11篇 |
1970年 | 13篇 |
1969年 | 16篇 |
排序方式: 共有1821条查询结果,搜索用时 15 毫秒
21.
Miriam Schuler Sebastian Mohnke Till Amelung Klaus M Beier Martin Walter Jorge Ponseti Boris Schiffer Tillmann H C Kruger Henrik Walter 《Social cognitive and affective neuroscience》2022,17(8):712
Behavioral studies found evidence for superior cognitive empathy (CE) in pedophilic men without a history of child sexual offending (P − CSO) compared to pedophilic men with a history of child sexual offending (P + CSO). Functional magnetic resonance imaging (fMRI) studies also point to differences between P − CSO and P + CSO. Neural processing associated with CE has not yet been investigated. Therefore, the present study aimed to explore the neural correlates of CE in subjects with pedophilia with (P + CSO) and without (P − CSO) child sexual offending. 15 P + CSO, 15 P − CSO and 24 teleiophilic male controls (TC) performed a CE task during fMRI. We observed reduced activation in the left precuneus (Pcu) and increased activation in the left anterior cingulate cortex (ACC) in P − CSO compared to P + CSO. P − CSO also showed stronger connectivity between these regions, which might reflect a top-down modulation of the Pcu by the ACC toward an increased self-focused emotional reaction in social situations. There was also evidence for increased right superior temporal gyrus activation in P − CSO that might constitute a potentially compensatory recruitment due to the dampened Pcu activation. These findings provide first evidence for altered neural processing of CE in P − CSO and underline the importance of addressing CE in pedophilia and CSO in order to uncover processes relevant to effective prevention of child sexual abuse. 相似文献
22.
Rafael Valencia-Quintana Sandra Gómez-Arroyo Stefan Marian Waliszewski Juana Sánchez-Alarcón José Luis Gómez-Olivares Ana Rosa Flores-Márquez Josefina Cortés-Eslava Rafael Villalobos-Pietrini 《Toxicology and Environmental Health Sciences》2012,4(3):154-160
Dimethyl sulfoxide (DMSO) is an organic solvent with several biological applications. It is extensively used to dissolve compounds that hardly dissolve in water to detect their genotoxic activity in vitro. In this study DMSO will be tested to determine its genotoxic potential. The effect of DMSO on the frequency of chromosomal aberrations in anaphase as well as DNA fragmentation through the comet assay has been evaluated in the meristematic cells of the root tips of Vicia faba. It has been observed that the frequency of chromosomal aberrations increases when the concentration of DMSO increases, reaching its maximum value with 20% of DMSO and decreasing at 30 and 40% of DMSO, in comparison to this maximum value, but significantly higher than the values observed in the control. Similarly, the percentage of fragmentation and damage index evaluated through the comet assay showed the same behavior; some of the possible mechanisms of action are discussed. 相似文献
23.
Juana Martínez César Ramón César Morís Julio Pascual Germán Morís 《World Journal of Clinical Cases》2014,2(6):211-214
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that almost exclusively involves motor neurons although autonomic dysfunction has also been reported. We present an 84-year-old female with no documented history of heart disease, who was admitted with negative T waves in the electrocardiogram precordial leads mimicking myocardial ischaemia. No other abnormalities were shown in the rest of the cardiologic evaluation, suggesting autonomic nervous system dysfunction. A neurophysiological study demonstrated acute and chronic denervation in multiple muscles with normal nerve conduction studies, confirming ALS diagnosis. Previous studies have shown that subclinical sympathetic hyperfunction and parasympathetic hypofunction might result in cardiovascular dysfunction in ALS patients. It is important to detect disturbances of autonomic cardiac control because this dysfunction may influence survival and quality of life, leading to a decrease in life expectancy in ALS patients. This Case Report may support the impairment of cardiac autonomic control in patients with ALS. 相似文献
24.
25.
Reversal of granulocyte adherence to nylon fibers using local anesthetic agents: possible application to filtration leukapheresis 总被引:1,自引:0,他引:1
The effects of the cationic anesthetic agents tetracaine and lidocaine on granulocyte function, morphology, and adherence to nylon fibers were studied in an attempt to improve current methods of granulocyte collection by filtration leukapheresis (FL). When dissolved in acid- citrate-dextrose (ACD) plasma, these drugs significantly increased granulocyte elution from the fibers in a dose-related fashion. Granulocytes exposed to tetracaine and lidocaine remained more than 95% viable, retained normal bactericidal capacity after the drugs were washed from the cells, and had preserved membrane integrity, as evidenced by the normal ultrastructural appearance of tetracaine- exposed cells and an absence of leakage of lysozyme or lactic dehydrogenase. Granulocytes eluted with the anesthetic agents were rounded in shape with a reduction in the number of filopodial cytoplasmic projections and a relative absence of cytoplasmic vacuolization when compared to granulocytes eluted with ACD plasma alone. Dose-related inhibition of phagocytosis and adherence, which was largely reversible after washing the granulocytes, was noted. Greater than 95% of the lidocaine could be removed from the eluate with a single centrifugation and resuspension, indicating that granulocytes prepared by FL with anesthetic-enhanced elution could be potentially transfusable. 相似文献
26.
Mestron A Webb SM Astorga R Benito P Catala M Gaztambide S Gomez JM Halperin I Lucas-Morante T Moreno B Obiols G de Pablos P Paramo C Pico A Torres E Varela C Vazquez JA Zamora J Albareda M Gilabert M 《European journal of endocrinology / European Federation of Endocrine Societies》2004,151(4):439-446
OBJECTIVE: To undertake a multicentre epidemiological study reflecting acromegaly in Spain. DESIGN: Voluntary reporting of data on patients with acromegaly to an online database, by the managing physician. METHODS: Data on demographics, diagnosis, estimated date of initial symptoms and diagnosis, pituitary imaging, visual fields, GH and IGF-I concentrations (requested locally), medical, radiotherapy and neurosurgical treatments, morbidity and mortality were collected. RESULTS: Data were included for 1219 patients (60.8% women) with a mean age at diagnosis of 45 years (s.d. 14 years). Reporting was maximal in 1997 (2.1 cases per million inhabitants (c.p.m.) per year); prevalence was globally 36 c.p.m., but varied between 15.7 and 75.8 c.p.m. in different regions. Of 1196 pituitary tumours, most were macroadenomas (73%); 81% of these patients underwent surgery, 45% received radiotherapy and 65% were given medical treatment (somatostatin analogues in 68.3% and dopamine agonists in 31.4%). Cures (GH values (basal or after an oral glucose tolerance test) <2 ng/ml, normal IGF-I, or both) were observed in 40.3% after surgery and 28.2% after radiotherapy. Hypertension (39.1%), diabetes mellitus (37.6%), hypopituitarism (25.7%), goitre (22.4%), carpal tunnel syndrome (18.7%) and sleep apnoea (13.2%) were reported as most frequent morbidities; 6.8% of the patients had cancer (breast in 3.1% of the women and colon in 1.2% of the cohort). Fifty-six patients died at a mean age of 60 years (s.d. 14 years), most commonly of a cardiovascular cause (39.4%); mortality was greater in patients given radiotherapy (hazard ratio 2.29; 95% confidence interval 1.03 to 5.08; P=0.026), and in those in whom GH and IGF-I concentrations were never normal (P<0.001). CONCLUSIONS: This acromegaly registry offers a realistic overview of the epidemiological characteristics, treatment outcome and morbidity of acromegaly in Spain. As active disease and treatment with radiotherapy are associated with an increase in mortality, efforts to control the disease early are desirable. 相似文献
27.
28.
29.
Fernández-Torres Javier Martínez-Nava Gabriela Angélica Zamudio-Cuevas Yessica Barbier Olivier Christophe Narváez-Morales Juana Martínez-Flores Karina 《Clinical rheumatology》2021,40(1):279-285
Clinical Rheumatology - Articular cartilage and periarticular muscle tissues are strongly affected during knee osteoarthritis (OA). Creatine kinase (CK) is an enzyme expressed in several tissues,... 相似文献
30.