全文获取类型
收费全文 | 68655篇 |
免费 | 2411篇 |
国内免费 | 208篇 |
专业分类
耳鼻咽喉 | 848篇 |
儿科学 | 1286篇 |
妇产科学 | 1351篇 |
基础医学 | 8784篇 |
口腔科学 | 3497篇 |
临床医学 | 5052篇 |
内科学 | 17163篇 |
皮肤病学 | 1532篇 |
神经病学 | 5580篇 |
特种医学 | 1241篇 |
外科学 | 8818篇 |
综合类 | 344篇 |
一般理论 | 21篇 |
预防医学 | 5935篇 |
眼科学 | 1450篇 |
药学 | 4669篇 |
3篇 | |
中国医学 | 320篇 |
肿瘤学 | 3380篇 |
出版年
2024年 | 362篇 |
2023年 | 506篇 |
2022年 | 696篇 |
2021年 | 1770篇 |
2020年 | 1002篇 |
2019年 | 1717篇 |
2018年 | 2626篇 |
2017年 | 1634篇 |
2016年 | 1606篇 |
2015年 | 2020篇 |
2014年 | 2522篇 |
2013年 | 3313篇 |
2012年 | 5817篇 |
2011年 | 6024篇 |
2010年 | 3167篇 |
2009年 | 2524篇 |
2008年 | 4850篇 |
2007年 | 5010篇 |
2006年 | 4698篇 |
2005年 | 4481篇 |
2004年 | 3946篇 |
2003年 | 3532篇 |
2002年 | 3283篇 |
2001年 | 367篇 |
2000年 | 341篇 |
1999年 | 343篇 |
1998年 | 301篇 |
1997年 | 265篇 |
1996年 | 227篇 |
1995年 | 191篇 |
1994年 | 156篇 |
1993年 | 156篇 |
1992年 | 160篇 |
1991年 | 148篇 |
1990年 | 115篇 |
1989年 | 98篇 |
1988年 | 64篇 |
1987年 | 54篇 |
1986年 | 73篇 |
1985年 | 84篇 |
1984年 | 82篇 |
1983年 | 66篇 |
1982年 | 83篇 |
1981年 | 74篇 |
1980年 | 60篇 |
1979年 | 51篇 |
1978年 | 43篇 |
1975年 | 33篇 |
1974年 | 52篇 |
1973年 | 39篇 |
排序方式: 共有10000条查询结果,搜索用时 10 毫秒
61.
Haiter-Neto F dos Anjos Pontual A Frydenberg M Wenzel A 《Clinical oral investigations》2008,12(3):217-223
The aim of this study was to compare detection of non-cavitated approximal caries lesions in images from seven solid-state intraoral digital receptors, with particular focus on two task-specific enhancement filters. One hundred and sixty approximal non-cavitated surfaces were radiographed under standardized conditions using the following seven intraoral solid-state digital receptors: two CMOS systems, Schick CDR-APS, and Kodak RVGui; and five CCD systems: Visualix, VistaRay, Dixi2, Sidexis, and Dr. Suni Plus. The Kodak RVGui digital images were captured with two task-specific, predefined enhancement filters ("dento-enamel" and "periodontal"). Eight observers examined the digital images for the presence or absence of approximal carious lesions. The teeth were subsequently sectioned for histological analysis, which served as the "gold standard" for the radiographic examination and allowed for a calculation of sensitivity, specificity, and overall accuracy. Both RVG modalities obtained the highest sensitivity values, which were significantly higher than with Visualix, Sidexis, and VistaRay images (all P = 0.03). The RVG "periodontal" images also had a higher accuracy than Dixi2, Dr. Suni Plus, and CDR-APS (P = 0.05). The RVG modalities also showed the largest observer variation, and their high sensitivities were mainly due to one observer. The sensitivity for VistaRay images was the lowest of all modalities and significantly lower than almost all the other digital systems (P = 0.02; except for Visualix). Besides, Visualix images had lower sensitivity than CDR-APS, Dixi2, and Dr. Suni Plus images (P = 0.003). On the other hand, the two RVGui image types showed the lowest mean specificity values. For overall accuracy, the differences among the modalities were non-significant (P > 0.05). 相似文献
62.
Bispo CG Tortamano IP Rocha RG Francischone CE Borsatti MA da Silva JC Medeiros AC 《Australian dental journal》2011,56(3):312-316
Background: The aim of this study was to evaluate the cardiovascular effects of maxillary infiltration using 2% lidocaine with 1:100 000 adrenaline, 4% articaine with 1:200 000 adrenaline, and 4% articaine with 1:100 000 adrenaline in different stages during restorative dental procedures. Methods: Twenty healthy patients randomly received 1.8 mL of the three local anaesthetics. Systolic blood pressure, average blood pressure, diastolic blood pressure, and heart rate were evaluated by the oscillometric and photoplethysmograph methods in seven stages during the appointment. Results: Statistical analysis by ANOVA and Tukey tests of cardiovascular parameters did not show significant differences between the anaesthetic associations. There were significant differences for the parameters among different clinical stages. Conclusions: The variation of cardiovascular parameters was similar for lidocaine and articaine with both adrenaline concentrations and showed no advantage of one drug over the other. Cardiovascular parameters were influenced by the stages of the dental procedures, which showed the effect of anxiety during restorative dental treatment. 相似文献
63.
Janson G de Souza JE de Freitas MR Henriques JF Cavalcanti CT 《The Angle orthodontist》2004,74(4):521-525
The objective of this study was to compare the occlusal changes of Class II malocclusion treatment provided by two different types of appliances. Group 1 comprised 25 patients treated with the Fr?nkel appliance and group 2 comprised 30 patients treated with the eruption guidance appliance. Evaluations were performed on the initial and final study models of the patients using the peer assessment rating (PAR) index. The final mean PAR index, the mean PAR change, and the percent PAR reduction of each group were compared using the Student's t-test. Results demonstrated that there were no statistically significant differences between the final PAR index, the PAR changes, and the percent PAR reduction of the two groups. Therefore, it was concluded that the occlusal changes provided by the two appliances are similar, as evaluated by the PAR index. 相似文献
64.
Stefani CM Nogueira F Sallum EA de TS Sallum AW Nociti FH 《Journal of periodontology》2002,73(2):206-212
BACKGROUND: This study investigated the influence of implant surface on osseointegration around titanium implants inserted in the tibiae of rabbits administered with nicotine. METHODS: Thirty-two (32) New Zealand rabbits were included in the study. After anesthesia, the tibia surface was exposed and 2 screw-shaped commercially available pure titanium implants 7.0 mm in length and 3.75 mm in diameter were placed bilaterally. A total of 128 implants were inserted: 64 blasted with Al2O3 particles (Group 1) and 64 with a machined surface finish (Group 2). The animals were randomly assigned to 1 of 4 treatment subgroups, and daily subcutaneous injections of nicotine were administered: A) saline solution; B) 0.37 mg/kg; C) 0.57 mg/kg; and D) 0.93 mg/kg. In order to label regenerated bone, a 2% calcein green solution was administered by intramuscular injection at 0, 7, and 15 days after implant insertion. After 42 days, the animals were sacrificed and undecalcified sections were prepared. The degree of bone contact with the implant surface, the bone area, and the intensity of bone labeling were measured into the limits of the implant threads. RESULTS: Statistical analysis (2-way ANOVA) revealed no significant difference regarding the effect of nicotine on bone healing around the implants (P>0.05). However, a significant influence of the implant surface on the degree of bone-to-implant contact was detected in groups C (30.13 +/- 4.97 and 37.85 +/- 8.85, for machined and Al2O3-blasted surfaces, respectively) and D (27.79 +/- 3.93 and 33.13 +/- 8.87, for machined and Al2O3-blasted surfaces, respectively) (P<0.05). CONCLUSIONS: Although nicotine administration may not statistically influence bone healing around titanium implants, implant surface design may enhance osseointegration after nicotine administration. 相似文献
65.
Sicknan Soares da Rocha Gelson Luis Adabo Ricardo Faria Ribeiro Renata Garcia Fonseca 《Journal of applied oral science : revista FOB》2007,15(4):247-252
As the adaptation of titanium crowns obtained by Rematitan Plus investment, specific for titanium, is not recognized to be suitable, this study evaluated the effect of the concentration of the specific liquid and the temperature of the mold of investments on the internal misfit of crowns cast on commercially pure titanium. Individual dies of epoxy resin were obtained, representing teeth prepared for full-crown restoration with a 6-degree axial surface convergence angle and shoulder (1.0 mm). For the waxing of each crown, a ring-shaped stainless steel matrix (8.0mm internal diameter; 7.5 mm height) was adapted above the individual dies of epoxy resin. The Rematian Plus investment was mixed according to the manufacturer''s instructions using two different concentrations of the specific liquid: 100%, 75%. Casting was performed in a Discovery Plasma Ar-arc vacuum-pressure casting machine with molds at temperatures of 430°C, 515°C and 600°C. The crowns were cleaned individually in a solution (1% HF + 13% HNO3) for 10 min using a ultrasonic cleaner, with no internal adaptations, and luted with zinc phosphate cement under a 5 kg static load. The crown and die assemblies were embedded in resin and sectioned longitudinally. The area occupied by cement was observed using stereoscopic lens (10X) and measured by the Leica Qwin image analysis system (mm2). The data for each experimental condition (n=8) were analyzed by Kruskal-Wallis non-parametric test (á=0.05). The results showed that liquid dilution and the increase in mold temperature did not significantly influence the levels of internal fit of the cast titanium crowns. The lowest means (±SD) of internal misfit were obtained for the 430°C/100%: (7.25 mm2 ±1.59) and 600°C/100% (8.8 mm2 ±2.25) groups, which presented statistically similar levels of internal misfit. 相似文献
66.
Selected endodontic pathogens in the apical third of infected root canals: a molecular investigation
Bacteria located at the apical portion of the root canals are conceivably in a strategic position to induce damage to the periradicular tissues and resulting inflammatory diseases. This study sought to investigate the prevalence of 11 selected putative endodontic pathogens in the apical third of infected root canals associated with periradicular lesions. The apical root portion of 23 extracted teeth with carious pulpal exposures and attached periradicular lesions was sectioned, and the root canals were sampled for microbiological investigation. DNA was extracted from the samples and analyzed for the presence of 11 bacterial species using a nested polymerase chain reaction assay. The results showed that Pseuramibacter alactolyticus occurred in 10 cases (44%), Treponema denticola in 6 (26%), Fusobacterium nucleatum in 6 (26%), Porphyromonas endodontalis in 4 (17%), Filifactor alocis in 2 (9%), Dialister pneumosintes in 1 (4%), Porphyromonas gingivalis in 1 (4%), and Tannerella forsythensis in 1 (4%). No sample yielded Prevotella intermedia, Prevotella nigrescens, or Campylobacter rectus. Of the samples examined, 17 were positive for at least 1 of the target species. Occurrence of these bacterial species in the apical third of infected root canals suggests that they can be involved in causation of periradicular lesions. 相似文献
67.
Bone density around titanium implants may be influenced by intermittent cigarette smoke inhalation: a histometric study in rats 总被引:2,自引:0,他引:2
Nociti FH César NJ Carvalho MD Sallum EA 《The International journal of oral & maxillofacial implants》2002,17(3):347-352
PURPOSE: This study investigated the influence of cigarette smoke on bone healing around titanium implants placed in rats. MATERIALS AND METHODS: After administration of anesthesia, the tibia surface was exposed and screw-shaped titanium implants (4.0 mm in length and 2.2 mm in diameter) were placed bilaterally (1 each side). The animals (n = 32) were randomly assigned to either group 1 (control, n = 18) or group 2 (intermittent cigarette smoke inhalation, n = 14). After 60 days, the animals were sacrificed and undecalcified sections obtained. Bone density (the proportion of mineralized bone in a 500-microm-wide zone lateral to the implant) was measured in the cortical (zone A) and cancellous bone (zone B) areas. RESULTS: In zone A, a slight difference in bone density was noted between the groups (96.18% +/- 1.08% and 95.38 +/- 1.17% in groups 1 and 2, respectively; P > .05) but was not statistically significant. In contrast, bone density was significantly decreased in zone B in the animals that were exposed to cigarette smoke (17.57 +/- 6.45% and 11.30 +/- 6.81% for groups 1 and 2, respectively; P < .05). DISCUSSION: Whether different results would be observed if animals were exposed to cigarette smoke for a longer period of time and/or before implant placement remains to be investigated. CONCLUSION: Although intermittent cigarette smoke exposure may not seriously affect cortical bone density, it may jeopardize bone quality around titanium implants in the cancellous bone area. 相似文献
68.
Leitão RF Rocha FA Chaves HV Lima V Cunha FQ Ribeiro RA Brito GA 《Journal of periodontology》2004,75(9):1227-1232
BACKGROUND: The role of nitric oxide (NO) on bone metabolism is controversial, since it can either stimulate bone formation or resorption. We investigated the effect of local administration of the NO donor isosorbide in an experimental periodontal disease model. METHODS: Wistar rats were subjected to a ligature placement around the cervix of the right second upper molar and were sacrificed after 11 days. Alveolar bone loss was measured in one quadrant as the sum of the distances between the cuspid tip and the alveolar bone along the axis of each molar root, which was subtracted from the contralateral side, used as unligated control. The semiquantitative histopathological scale of the periodontium was based on cell infiltration and alveolar bone and cementum integrity. Groups were treated with a gel containing 1% or 5% isosorbide applied to the vestibular side of the molar gingiva 1 hour before the placement of the ligature and then twice daily until sacrifice. Controls included one group subjected to periodontitis and no treatment (NT) and another that received the gel containing just the vehicle (V). RESULTS: The application of the vehicle gel produced an increase of the alveolar bone resorption, without altering the inflammatory changes, compared to the NT group. The 5% isosorbide produced a significant reduction of the alveolar bone resorption, compared to V and NT. This reduction was confirmed by histological analysis, showing less inflammatory cell infiltration and preservation of the cementum and the alveolar process. CONCLUSION: Local application of isosorbide reduces alveolar bone resorption in experimental periodontal disease in rats, suggesting a local anti-inflammatory effect of isosorbide. 相似文献
69.
Limongi O Klymus AO Baratto Filho F Vanni JR Travassos R 《Journal of applied oral science : revista FOB》2004,12(3):195-199
The present study conducted an in vitro evaluation of the presence of apical deviation on the root canal preparation of the mesiobuccal roots of human maxillary molars employing automated handpieces with continuous motion, the Pow R system (Moyco Union Broach), and alternate motion, the M4 system (Kerr). Analysis of the presence of apical deviation was carried out by means of radiographs obtained on a radiographic desk fabricated for the study. The results demonstrated the lack of statistically significant differences between the two systems as to the evaluation of the presence of apical deviation. There was no correlation between the degree of curvature of the roots and the degree of apical deviation for the continuous motion system. However, there was a statistic difference for the alternate motion system, with a direct correlation of moderate degree. 相似文献
70.
Evaluation of endodontic treatments performed by students in a Brazilian Dental School 总被引:1,自引:0,他引:1
De Quadros I Gomes BP Zaia AA Ferraz CC Souza-Filho FJ 《Journal of dental education》2005,69(10):1161-1170
The aims of this study were to evaluate the clinical outcomes of root canal treatments performed by final-year students in the Dental School of Piracicaba, State University of Campinas, SP, Brazil, during the year 2000 and to evaluate the success rate of these treatments at follow-ups conducted one and three years later (2001-03). All 579 endodontic treatments performed by final-year students were selected for this investigation. Detailed personal and dental history was obtained from the patient's records. Clinical and radiographic follow-up examinations were performed. For 78.8 percent of the cases, dental caries was recorded as the cause for performing endodontic treatment; for 8.8 percent, prosthetic reasons were given; and for 12.4 percent, failure of the endodontic treatment was the reason. The largest percentage (30.7 percent) of recalled patients was examined after one year; the success rate at this follow-up evaluation ranged from 83 percent to 96 percent depending on the pulp status prior to the root canal treatment. After three years, only 8 percent of treated patients returned; assessment for them revealed a 75.5 percent success rate. Dental caries is still the main reason for endodontic treatment. This level of success of the root canal treatment in a Brazilian dental school is similar to other reports in the literature. 相似文献