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31.
The purpose of this paper is to describe the design and development of the Clinical Practice Library of Medicine (CPLM). CPLM is an investigational project aimed at providing health care practitioners with critical in-depth information similar to that obtained from a medical reference library or consultant. When used in conjunction with the physician's knowledge, CPLM can provide valuable diagnostic prompting information to assist in rapidly reaching a suitable diagnosis for timely administration of appropriate treatment. This system may also be used to assist paramedical professionals working in remote areas where other expert medical assistance may not be available. 相似文献
32.
Extracranial carotid disease accounts for up to 50 percent of strokes. Transient ischemic attacks are associated with a 30 to 35 percent risk of stroke within five years of the initial episode. Carotid endarterectomy is a safe and effective way of reducing the risk of stroke in patients with TIAs. It is also helpful in patients with amaurosis fugax, and may benefit selected patients with acute stroke or those with asymptomatic but hemodynamically significant stenosis. 相似文献
33.
Bone morphogenetic protein (BMP) was isolated from the bone matrix of swine and partially purified by means of differential precipitation and molecular sieve chromatography. The molecular weight of BMP estimated by SDS-gel electrophoresis was 19,000 dalton. Bioassay by implanting two milligrams of BMP fraction into thigh muscles of mice resulted in bone formation in 100% of the experimental animals.
相似文献
34.
小儿肾积水Anderson-Hynes手术后并发症及其治疗 总被引:1,自引:0,他引:1
对52例(54侧)先天性肾盂输尿管连接部梗阻性肾积水患者行Anderson-Hynes手术,对其手术的并发症进行分析,主要并发症为吻合口梗阻(39%)和泌尿系感染(28%).经腹进行手术,肠梗阻发生率为13%(3/23).患儿手术时年龄与手术后并发症发生率无显著性意义. 相似文献
35.
铜绿假单胞菌全细胞脂肪酸气相色谱分析及应用 总被引:5,自引:0,他引:5
本研究用计算机控制,可程序升温的毛细管柱气相色谱(GC)仪分析48株铜绿假单胞菌标准株和临床株、部分常见假单胞菌、肠杆菌的细胞脂肪酸。结果表明:月桂烯酸(C12:1),月桂酸(C12:0)、十三碳烯酸(C13:1)、十三碳酸(C13:0)、肉豆劳动脑酸(C14:1)、十七碳稀酸(C17:1)、十七碳酸(C17:0)、硬脂酸(C18:0)和花生四烯酸(C20:4)是铜绿包菌有鉴别意义的脂肪酸,组成与 相似文献
36.
Jin Woo Kim M.D. Ho Shik Kim M.D. In Kyung Kim M.D. Mee Ran Kim M.D. Eun Young Cho B.S. Heung Kee Kim M.D. Joon Mo Lee M.D. Sung Eun Namkoong M.D. 《Gynecologic oncology》1998,69(3):230-236
Transforming growth factor-β1 (TGF-β1) is known to be a potent growth inhibitor for many cell types, including most epithelial cells. In skin keratinocytes, TGF-β1 has been shown to inhibit growth and to rapidly reduce c-mycexpression. However, the molecular mechanism of TGF-β1 action on cell growth of cervical carcinoma has not yet been elucidated. We thus assessed the effect of TGF-β1 on the growth of cervical carcinoma cell lines. Two cervical squamous carcinoma cell lines, CUMC-3 and CUMC-6, were incubated with varying concentrations of TGF-β1, and growth inhibition was evaluated with tetrazolium-based colorimetric assay. After culture in TGF-β1 for 24 h, inhibition of growth was detected in a dose-dependent manner at concentrations of 0.1–10 ng/ml in both cell lines. This effect of TGF-β1 on cultured carcinoma cells was associated with apoptotic process including oligonucleosomal ladder DNA and apoptotic body formations. Northern blot analysis revealed c-mycmRNA expression was suppressed by 10 ng/ml of TGF-β1 following 3 h of treatment in both cell lines. Western blot analysis showed that the level of p27Kip1protein was increased after TGF-β1 treatment in both cell lines. These results suggest that the mechanisms by which TGF-β1 inhibits the growth of cervical carcinoma are complex and may include effects on down-regulation of c-mycgene, and overexpression of p27Kip1protein. 相似文献
37.
38.
补肾中药对雄激素致不孕大鼠卵巢核仁组成区蛋白的影响 总被引:4,自引:0,他引:4
观察补肾中药对雄激素致不孕大鼠卵巢核仁组成区蛋白的影响。用SD雌性大鼠幼仔,出生9d龄注射丙酸睾丸酮,制成雄激素致不孕大鼠(ASR)模型。80d龄灌服补肾中药水溶液两周。100d龄心脏灌注处死。以核仁组成区蛋白嗜银染色(AgNOR)和增殖细胞核杭原(PcNA)为指标,观察卵巢颗粒细胞、间质腺细胞的形态学变化。结果:补肾中药能够使ASR卵巢颗粒细胞增殖、卵泡发育。治疗组的AgNOR和PcNA计数明显高于模型组,而与对照组之间无显著差异。结论:补肾中药的这种作用可能是通过调节了下丘脑-垂体-卵巢性腺功能的结果,从而促使卵巢颗粒细胞发育、卵泡成熟。 相似文献
39.
Effects of smoking and drinking on excretion of hippuric acid among toluene-exposed workers 总被引:1,自引:1,他引:0
Osamu Inoue Kazunori Seiji Takao Watanabe Haruo Nakatsuka Chui Jin Shi-Jie Liu Masayuki Ikeda 《International archives of occupational and environmental health》1993,64(6):425-430
Summary In order to investigate possible effects of smoking and drinking on the metabolism of toluence in occupational settings, 206 toluene-exposed men (mean age: 31.4 years) in shoemaking, painting, or surface-coating workshops together with 246 nonexposed control men (36.8 years) were studied for the time-weighted average intensities of exposure to toluene, hippuric acid concentration in shift-end urine samples, and the two social habits of smoking and drinking. The mean daily consumptions of cigarettes and ethanol were about 20 pieces and 10 g among smokers and drinkers, respectively. The geometric mean toluene concentration among the exposed subjects was about 20 ppm, with a maximum of 521 ppm. Regression analysis after classification of the subjects by smoking and drinking clearly demonstrated that the two social habits, when combined, markedly reduce the hippuric acid level in the urine of workers exposed to was a significant association between smoking and drinking habits, which hindered separate evaluation of the effects of the two habits on toluene metabolism. Comparison of the present results with the findings reported in the literature, however, suggested that the observed effects may be attributable to smoking rather than to drinking habits. 相似文献
40.