复方天棘胶囊对老龄鼠血气影响的研究

本研究选用昆明种老龄鼠５０只，随机分为正常对照组、阳性对照组和复方天棘胶囊高、中、低剂量组；每组１０只。观察灌服复方天棘胶囊溶液对实验性老龄鼠血气的影响。结果表明，老龄鼠灌服２．０、１．０和０．５ｇ／ｋｇ体重复方天棘胶囊溶液及５．０ｇ／ｋｇ体重红参水煎液１０天后，复方天棘胶囊各剂量组均有不同程度的升高动脉血氧分压（ＰａＯ＿２）和血氧饱和度（ＳａＯ＿２）的作用；且随剂量的递增，ＰａＯ＿２和ＳａＯ＿２明显升高，其中高剂量组升高ＰａＯ＿２和ＳａＯ＿２的作用最为明显（Ｐ＜０．０１）；红本组ＳａＯ＿２也有明显升高（Ｐ＜０．０１）。提示复方天棘胶囊具有升高ＰａＯ＿２和ＳａＯ＿２的作用。     

Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions

We immunohistochemically analyzed kallikrein 4 protein (hK4) expression in patients with epithelial ovarian carcinoma (181 malignant effusions and 103 solid carcinoma lesions). Expression of hK4 was also studied in 32 effusions using immunoblotting. Carcinoma cells expressed hK4 in 144 (79.6%) of 181 effusions and 85 (82.5%) of 103 solid tumors. Expression was seen in 51% or more of tumor cells in 70 effusions but often was limited to 5% or fewer cells in solid tumors (P = .009, primary tumors vs effusions; P = .002, metastases vs effusions). Immunoblotting showed hK4 expression in 31 of 32 specimens. Stromal cell hK4 expression, seen in 48 (46.6%) of 103 lesions, was significantly higher in primary tumors than metastases (26/43 vs 22/60, P = .019). hK4 expression in tumor cells was significantly lower in International Federation of Gynecology and Obstetrics stage IV than stage III tumors (P = .004, all lesions; P = .012, primary tumors). hK4 expression in carcinoma cells was associated with longer overall survival (not significant; P = .14, peritoneal effusions). hK4 is expressed widely in ovarian carcinoma; levels in carcinoma cells are highest in effusions, which might be related to loss of stromal contribution and/or altered microenvironment. hK4 expression in carcinoma cells of effusions or solid tumors does not predict survival.     

人脐静脉内皮细胞清除补体攻膜复合物的机制

目的：探讨内皮细胞清除补体攻膜复合物（MAC）的途径及其清除动力学，方法：原代培养的人脐静脉内皮细胞以RH414荧光标记质膜双层，0℃组装亚溶剂量的MAC，37℃复苏后，LSCM实时监MAC沉积诱导的质膜囊泡化形成和胞吞，胞吐情况,流式细胞仪定量检测内皮细胞表面MAC抗原的清除情况，结果：MAC沉积后，内皮细胞有的质膜囊泡化形成，囊泡以胞吞和胞吐2种方式离开细胞，并以前者占优，37度条件下，内皮细胞清除表面MAC的半衰期约为5min。结论：内皮细胞可通过胞吞和胞吐2种机制清除细胞表面沉积的MAC，并以胞吞方式为主。     

T cell stimulation in the absence of exogenous antigen: a T cell signal is induced by both MHC-dependent and -independent mechanisms

Mature T cells residing in peripheral lymphoid organs have frequent contact with antigen presenting cells (APC). Such contact may be required for T cell survival, but the degree to which signals in mature T cells are induced by TCR recognition of self peptide/MHC complexes is unclear. We have used induction of the early growth response gene 1 (Egr1) as an indicator of signal transduction in 3.L2 (I-Ek-restricted) T cells interacting with APC in the absence of exogenous antigen. The data show that Egr1 can be induced in 3.L2 T cells by TCR recognition of self peptides presented by I-Ek. However, a more transient induction of Egr1 can be induced in 3.L2 T cells interacting with dendritic cells derived from class II/beta2m double-deficient mice. Egr1 induction after T cell-APC contact was also observed in a freshly isolated polyclonal CD4 T cell population. The data suggest that self peptide/MHC recognition by the TCR induces a signal in T cells and that dendritic cells can also induce a more transient T cell signal by an MHC-independent mechanism.     

Effects of acute hypoxia on ventilatory response at the onset of submaximal exercise

In order to investigate the effects of acute hypoxia and accompanying hypocapnia on the ventilatory response at the onset of dynamic exercise, four healthy adult men performed 50W rectangular loads on a cycle-ergometer in normoxic (FIO2 = 0.21) and hypoxic (FIO2 = 0.11) conditions. No statistically significant differences in the initial ventilatory responses to exercise (both delta VI and delta VE assessed on a breath-by-breath basis) were found between eucapnic normoxia (PETO2 approximately 95, PETCO2 approximately 42 Torr) and hypocapnic hypoxia (PETO2 approximately 45, PETCO2 approximately 35 Torr). The present findings support the contention that the neurogenic ventilatory drive at the onset of early exercise is independent from PO2 and PCO2.     

眼科设备数据库设计初探

本文介绍了一所眼科医院设备数据库的设计思路,数据库内容以及用途。     

开胸术后呼吸衰竭2 6例临床分析

目的:探讨开胸术后呼吸衰竭的发病原因、临床特点及有效的预防、治疗方法.方法:对本院1993年1月～1999年4月开胸术后并发呼吸衰竭的发病情况及其治疗结果进行统计分析.结果:术前心肺功能异常、麻醉、手术创伤、感染、术后出血等为术后呼吸衰竭的主要原因,其发生率为3.56%(26/730),死亡率为23.1%(6/26).结论:加强围手术期呼吸道管理,减轻手术创伤,预防和正确处理术后并发症是防止呼吸衰竭的关键,及时有效的机械通气是抢救成功的最有效手段.     

Comparison of a fractional 2940-nm Er:YAG laser and 5% amorolfine lacquer combination therapy versus a 5% amorolfine lacquer monotherapy for the treatment of onychomycosis: a randomized controlled trial

Lasers in Medical Science - Onychomycosis is a fungal infection of the nail. The aim of this randomized controlled clinical trial was to compare the efficacy of 2940-nm Er:YAG laser treatment...     

中药解郁胶囊治疗老年抑郁症的临床疗效观察

目的：观察中药解郁胶囊对老年抑郁症的临床疗效和安全性。方法：选取2020年11月至2021年12月甘肃中医药大学附属医院住院或门诊患者200例作为研究对象,按照纳入标准最终产生研究观察对象100例,健康对照组来自我院组织的年龄在60~80岁的健康体检的老年人100例。观察组中男37例,女63例,对照组中男43例,女57例。对照组采取常规治疗,观察组采取中医综合疗法治疗。对2组患者治疗前后减分情况、中医证候分析、服药及依从情况、不良反应及抑郁焦虑因子等无创性指标的影响。结果：对老年抑郁症的治疗效果主要从汉密尔顿抑郁量表减分情况及证候减分率体现,2组经过12个月中药和抗抑郁综合治疗,中医证候量表减分率（8.2±3.1）和（7.8±3.2）,比对照组的（8.8±3）与（8.4±3.6）,P值为0.001 6和0.001 3,治疗前后均有明显变化,差异有统计学意义（P<0.05）,中医证候量表减分率比较,差异有统计学意义（P<0.05）,从服药后出现的不良反应来看,中医综合观察组应明显低于对照观察组,差异有统计学意义（P<0.05）。从中医组治疗患者的依从性分析,差异有统计学意义（P<0.05）。结论：中药解郁胶囊与中医综合治疗患者治疗效果显著,依从性更佳。     

Phase-Field-Based Axisymmetric Lattice Boltzmann Method for Two-Phase Electro-Hydrodynamic Flows

In this work, a novel and simple phase-field-based lattice Boltzmann (LB) method is proposed for the axisymmetric two-phase electro-hydrodynamic flows. The present LB method is composed of three LB models, which are used to solve the axisymmetric Allen-Cahn equation for the phase field, the axisymmetric Poisson equation for the electric potential, and the axisymmetric Navier-Stokes equations for the flow field. Compared with the previous LB models for the axisymmetric Poisson equation, which can be viewed as the solvers to the convection-diffusion equation, the present model is a genuine solver to the axisymmetric Poisson equation. To test the capacity of the LB method, the deformation of a single leaky or perfect dielectric drop under a uniform electric field is considered, and the effects of electric strength, conductivity ratio, and permittivity ratio are investigated in detail. It is found that the present numerical results are in good agreement with some available theoretical, numerical and/or experimental data.