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排序方式: 共有414条查询结果,搜索用时 31 毫秒
61.
Jahng JW Kim NY Ryu V Yoo SB Kim BT Kang DW Lee JH 《European journal of pharmacology》2008,581(1-2):64-70
This study was conducted to define the regulatory mechanisms underlying stress-induced decreases in food intake and weight gain. Rats received a single or 4 daily injections of dexamethasone (0.1 or 1 mg/kg). Food intake and weight gain were recorded, and plasma leptin, brain contents of serotonin (5-hydroxytryptamine; 5-HT), 5-hydroxy-indole-acetic acid (5-HIAA) and the raphe expression of tryptophan hydroxylase (TPH), monoamine oxidase A (MAO-A) and 5-HT reuptake transporter (5-HTT) genes were examined. A single injection of dexamethasone did not acutely affect food intake, but cumulative food intake and weight gain were suppressed dose-dependently by daily injections of dexamethasone. Both a single and repeated injections of dexamethasone elevated plasma leptin in a dose dependent manner. 5-HT contents in the hypothalamus was decreased, but 5-HIAA increased, both by a single and repeated dexamethasone. A single injection of dexamethasone did not affect mRNA expressions of TPH, MAO-A and 5-HTT genes, but repeated dexamethasone increased them in the dorsal raphe nucleus. These results suggest that plasma leptin may play a role in dexamethasone-induced anorexia. Additionally, increased expression of MAO-A and 5-HTT genes by repeated dexamethasone appears to be implicated in decreases of the brain 5-HT contents. 相似文献
62.
T J Kowalski T A Houpt J Jahng N Okada S M Liu S C Chua G P Smith 《Physiology & behavior》1999,67(4):521-525
Hypothalamic preproNPY overexpression in the Zucker fatty (fa/fa) rat was examined. In situ hybridization was used to determine the relative level of preproNPY mRNA in the arcuate nucleus of +/+, +/fa, and fa/fa pups aged postnatal day 2 (P2), 5, 9, 12, or 25. The relative optical density (ROD) of probe hybridization in the arcuate, the area of hybridization (A), and the product of ROD x A (a measure of total arcuate preproNPY mRNA hybridization) were measured. Values were normalized to the mean +/fa value within each litter. Initial analysis showed that preproNPY mRNA hybridization (ROD x A) in fa/fa pups was significantly higher than +/fa and +/+ pups on P9, 12, and 25, and significantly higher than +/fa on P5. No significant difference between lean (+/+ and +/fa) genotypes, however, were observed at any age tested. Values from the lean genotypes were, therefore, pooled, and data were normalized to the mean value of lean animals for analysis. This analysis revealed that preproNPY mRNA hybridization in fa/fa pups was higher than lean littermates as early as P2. 相似文献
63.
Hyun-Woong Cho Kyung-Jin Min Sang-Hoon Kwon Kidong Kim Sunghoon Kim Seok Ju Seong Yong Jung Song Keun Ho Lee Shin-Wha Lee Jeong-Won Lee Woong Ju Young Tae Kim Jae Kwan Lee 《Journal Of Gynecologic Oncology》2021,32(6)
Since the human papillomavirus (HPV) vaccine guidelines were developed by the Korean Society of Gynecologic Oncology (KSGO) in 2011, 2016, and 2019, several recent studies on the efficacy and safety of HPV vaccines in middle-aged women and men have been reported. Furthermore, there has been an ongoing debate regarding the efficacy of the HPV vaccine in women with prior HPV infection or who have undergone conization for cervical intraepithelial neoplasia (CIN). We searched and reviewed studies on the efficacy and safety of the HPV vaccine in middle-aged women and men and the efficacy of the HPV vaccine in patients infected with HPV and those who underwent conization for CIN. The KSGO updated their guidelines based on the results of the studies included in this review. 相似文献
64.
Wen Lihui Shin Min-Ho Kang Ji-Hyoun Yim Yi-Rang Kim Ji-Eun Lee Jeong-Won Lee Kyung-Eun Park Dong-Jin Kim Tae-Jong Park Yong-Wook Kweon Sun-Seog Lee Young-Hoon Yun Yong-Woon Lee Shin-Seok 《Clinical rheumatology》2018,37(4):1099-1106
Clinical Rheumatology - Due to the inconsistent association between high-sensitivity C-reactive protein (hs-CRP) and osteoarthritis (OA), we evaluated the relationship between hs-CRP and various... 相似文献
65.
66.
李伯翰 Sang Bae Yoo Samir Jabaiti Soung-Min Kim Zhihong Lin Mi-Ae Sung Myung-Jin Kim Jeong Won Jahng Jong-Ho Lee 《中国神经再生研究》2010,5(16):1216-1219
摘要:
背景和目的:
周围神经损伤修复的最佳方式是自体神经移植,然而自体神经移植造成患者的二次损伤使其在临床的应用中受到局限。雪旺细胞是周围神经组织工程研究的重要的种子细胞,需要对雪旺细胞进行体外培养、增殖和传代。由于雪旺细胞的增殖相当缓慢,培养周期长等方面限制。许多研究者转向中医药干预的方法进行探寻。令人欣慰的是:相关的实验传统复方制剂FBD能维持神经元生存和生长并促进BDNF等分泌物。本项研究将依据独特的实验模型,采用研究者选用中国药品生物制品检定所提纯的人参皂甙Rb1,加入体外培养的雪旺细胞中进行实验,观察细胞加药后的生长情况。
方法:利用SD雄性大鼠雪旺细胞株(ISC),加入不同浓度的FBD,利用MTT比色分析法、RT-PCR, ELISA,测定法检测不同浓度FBD在不同培养时间对体外培养大鼠雪旺细胞增殖的影响。
结果:FBD在20微克/毫升的浓度对雪旺细胞增殖有明显促进作用。而50微克/毫升FBD对细胞增殖的促进作用与对照组相近。
结论 : FBD有促进体外培养雪旺细胞快速增殖的作用,从而为促进神经损伤的再生途径提供一些新的药物使用基础研究。 相似文献
67.
J.A. Lee C.K. Kim G.H. Jahng L.K. Hwang Y.W. Cho Y.J. Kim W.H. Lee S.J. Moon A.R. Cho G.H. Bahn 《Progress in neuro-psychopharmacology & biological psychiatry》2010
Objectives
In order to reveal the etiology and pathophysiology of trichotillomania (TTM), it is necessary to investigate which brain regions are involved in TTM, but limited knowledge exists regarding the neurobiology of TTM and the available functional neuroimaging studies of TTM are little. The purpose of the present study was to investigate the specific brain regions involved in the pathophysiology of TTM with symptom provocation task using functional magnetic resonance imaging (fMRI) for children and adolescents with TTM.Methods
Pediatric subjects who met the DSM-IV TR criteria for TTM (n = 9) and age-, sex-, handedness-, IQ matched healthy controls(HC) (n = 10), ages 9 to 17 years, were recruited for two fMRI experiments; symptom provocation of Visual Only (VO) and Visual and Tactile (VT). They were scanned while viewing two alternating blocks of symptom provocation (S) and neutral (N) movies.Results
Random effects between-group analysis revealed significant activation in left temporal cortex(including middle and superior temporal gyrus), dorsal posterior cingulate gyrus, and putamen for the contrast S > N in TTM subjects versus HC subjects during the VO session. And TTM subjects demonstrated higher activity in the precuneus and dorsal posterior cingulate gyrus to the contrast S > N during the VT session.Conclusions
This study provided an objective whole-brain-based analysis that directed researchers to areas that were abnormal in TTM. Using the symptom provocation tasks, we found significant differences in regional brain function between pediatric TTM and HC subjects. However, in the face of modest statistical power, our preliminary findings in TTM need to be replicated in a larger sample. As the functional neuroanatomic circuits involved in TTM remain largely unexplored, future functional neuroimaging studies using other various paradigms may help investigate the neuroanatomic abnormalities of TTM. 相似文献68.
Min Kyu Kim Sang Yong Song In-Gu Do Seo-Hee Kim Chel Hun Choi Tae-Joong Kim Jeong-Won Lee Duk-Soo Bae Byoung-Gie Kim 《Journal Of Gynecologic Oncology》2011,22(4):233-238
Objective
Lynch syndrome is a hereditary cancer syndrome that increases the risks of colorectal and gynecologic malignancies such as endometrial and ovarian cancer. Studies have shown that mutations in mismatch repair genes (MSH2, MSH6, and MLH1) are associated with Lynch syndrome. The aim of our study was to estimate the value of MSH2, MSH6, and MLH1 immunohistochemistry based on family history in a Korean sample.Methods
Thirty six women with synchronous gynecologic tumors of endometrial and ovarian cancer were identified among patients being treated at our institution. Among them, 32 patients had tumor blocks (total 62 slides) available for analysis. According to a diagnostic algorithm, we performed immunohistochemistry analyses. Staining was scored based on intensity and proportion (negative or 0: intensity undetectable or minimal, proportion <5%; weak or 1+: intensity mild, proportion 5-30%; strong or 2+: intensity moderate to marked, proportion 30-99%).Results
Among 32 eligible patients, 9 (28%) had a family history of cancer. Six patients (19%) were negative for MLH1; among them, four (4/6) were negative at both sites. Nine patients (28%) were negative for MSH2 or MSH6 at both sites or negative for both MSH2 and MSH6. Among these three patients showed negative staining for both sites. The three patients showing negative staining for MLH1, MSH2, and MSH6 at both sites with family history were considered to be the screening positive groups of Lynch syndrome.Conclusion
In this study, the frequency of Lynch syndrome associated immunohistochemical staining (MLH1, MSH2, and MSH6) group was estimated as 9% (3/32) among Korean women with synchronous gynecologic tumors. 相似文献69.
70.
Jin Sun Park Ji Yoon Ryu Hye-Kyung Jeon Young Jae Cho Young Ae Park Jung-Joo Choi Jeong-Won Lee Byoung-Gie Kim Duk-Soo Bae 《Journal Of Gynecologic Oncology》2012,23(3):190-196