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D. R. E. ABAYASEKARA L. O. KURLAK J. Y. JEREMY P. DANDONA R. M. SHARPE B. A. COOKE 《International journal of andrology》1990,13(5):408-418
The possible involvement of two arachidonic acid metabolites, prostaglandin F2 alpha (PGF2 alpha) and leukotriene B4 (LTB4), in the stimulatory effect of human chorionic gonadotrophin (hCG) on the volume of interstitial fluid (IF) in the rat testis has been investigated. Administration of hCG caused a time- and dose-dependent increase in the IF levels of PGF2 alpha while LTB4 showed no clear dose-dependence, but did decrease significantly at 2-8 h after injection of 100 IU hCG. Administration of ethane dimethane sulphonate (EDS), which specifically destroys Leydig cells, decreased the volume of IF but the IF levels of LTB4 and PGF2 alpha were unchanged. This indicates that although the absence of Leydig cells results in significant changes in IF volume, LTB4 and PGF2 alpha are probably not involved in these changes. Furthermore, these findings suggest that Leydig cells are not the only contributors to LTB4 and prostaglandins E2 and F2 alpha in testicular IF. In rats injected peripherally with hCG, intratesticular administration of the cycloxygenase inhibitor, indomethacin, decreased PGF2 alpha levels in IF after 2 and 4 h but not at later times. However, no inhibitory effect of indomethacin on the hCG-stimulated increase in IF volume was detected; indeed, at 2 h after injection of indomethacin + hCG there was a significant increase in IF volume in the indomethacin-injected testis. It is concluded that, although prostaglandins and LTB4 are secreted into IF in the rat testis, these arachidonic acid metabolites are apparently not the primary mediators of the increase in IF volume that follows hCG treatment. 相似文献
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MICHAEL H. LEHMANN SANJEEV SAKSENA Editors MICHAEL H. LEHMANN SANJEEV SAKSENA MASOOD AKHTAR J. THOMAS BIGGER JR. A. JOHN CAMM ELIZABETH J. DARLING LEONARD DREIFUS MARGARET FAUST JOHN D. FISHER SEYMOUR FURMAN NORA F. GOLDSCHLAGER JERRY C. GRIFFIN THOMAS GUARNIERI GERARD M. GUIRAUDON J. WARREN HARTHORNE JEREMY N. RUSKIN RICHARD M. LUCERI JAMES D. MALONEY FRANCIS E. MARCHLINSKI ROBERT J. MYERBURG LOIS SCHURIG GERALD C. TIMMIS ALBERT L. WALDO SALIM YUSUF DOUGLAS P. ZIPES 《Journal of interventional cardiology》1991,4(3):211-220
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ANDREA NATALE ANTONIO RAVIELE AMIN AL‐AHMAD OTTAVIO ALFIERI ETIENNE ALIOT JESUS ALMENDRAL GÜNTER BREITHARDT JOSEP BRUGADA HUGH CALKINS DAVID CALLANS RICCARDO CAPPATO JOHN A. CAMM PAOLO DELLA BELLA GERARD M. GUIRAUDON MICHEL HAÏSSAGUERRE GERHARD HINDRICKS SIEW YEN HO KARL H. KUCK FRANCIS MARCHLINSKI DOUGLAS L. PACKER ERIC N. PRYSTOWSKY VIVEK Y. REDDY JEREMY N. RUSKIN MAURICIO SCANAVACCA KALYANAM SHIVKUMAR KYOKO SOEJIMA WILLIAM J. STEVENSON SAKIS THEMISTOCLAKIS ATUL VERMA DAVID WILBER 《Journal of cardiovascular electrophysiology》2010,21(3):339-379
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JEREMY N.S. EVANS JAROSLAV ZAJICEK MARK S. NISSEN GERHARD MUNSKE VIRGINIA SMITH RAYMOND REEVES 《Chemical biology & drug design》1995,45(6):554-560
The HMG-I subfamily of high mobility group (HMG) chromatin proteins consists of DNA-binding proteins that preferentially bind to stretches of A·T-rich sequence both in vitro and in vivo. Recently, members of the HMG-I family have been suggested to bind in vitro to the narrow minor groove of A·T-DNA by means of an 11 amino acid peptide binding domain (BD) which, because of its predicted structure, is called the‘A·T-hook motif [Reeves, R. & Nissen, M. (1990) J. Biol. Chem. 265 , 8573–8582], and would appear to be crescent-shaped. A BD peptide with 13 amino-acid residues was synthesized and examined by proton and carbon-13 nuclear magnetic resonance (NMR) spectroscopy. The peptide contains four proline residues, and on the basis of NOES and 13C chemical shifts was found to exist in an all-trans conformation. Molecular modelling based on this result provides evidence for a dynamic equilibrium between turn-like conformations in solution, the most populated of which is likely to be an S-shaped conformer, on the basis of amide exchange data. © Munksgaard 1995. 相似文献
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BRIAN McGOVERN MARK H. SCHOENFELD JEREMY N. RUSKIN HASAN GARAN PETER M. YURCHAK 《Pacing and clinical electrophysiology : PACE》1986,9(3):449-462
Ventricular tachycardia is now diagnosed frequently in patients with organic heart disease. Although ventricular tachycardia was first demonstrated electrocardiographically 75 years ago, the natural history, fundamental mechanisms, and optimal management have remained elusive. Early observers commented on the rarity of occurrence and poor prognosis associated with this arrhythmia, yet with time, some patients with ventricular tachycardia were reported to survive for prolonged periods. Because of the sporadic nature of the arrhythmia and its variable prognosis, assessment of the efficacy of therapies has been difficult. A wide variety of treatments has been advocated with enthusiasm, but only a few have been consistently reported to be effective. Citation of historical data to claim benefit from new treatments should be viewed with caution. 相似文献