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951.
952.
OBJECTIVES: To pilot the acceptability and feasibility of clinical audit in free and pedicled flap reconstruction. To establish a baseline flap failure rate in participating units, so that a sample size calculation could be performed for future national audit. METHODS: A proforma was piloted over a 3-month period in four participating units, during which time data on 93 reconstructive procedures involving free and pedicled flaps was collected. The patients included those where large transfers of tissue were required such as for coverage of grade IIIb compound tibial fractures and breast reconstruction after mastectomy, and also smaller flap transfers such as after skin cancer excision. RESULTS: The proforma was found to be acceptable to clinicians and the feasibility of the data collection process was established. Overall there was a total flap survival of 89% and secondary operations to the donor or recipient sites were required in 11% of patients. CONCLUSIONS: This study demonstrates the feasibility of comparative audit for free and pedicled flap procedures using the methods proposed. Based on the incidence of flap failure observed in this pilot study, at least 18 months of prospective data collection on consecutive patients is required to fulfil the statistical requirements of comparative audit. The establishment of a routinely collected minimum dataset is proposed as one means of meeting these requirements. 相似文献
953.
954.
Posttraumatic stress disorder and associated risk factors in Canadian peacekeeping veterans with health-related disabilities. 总被引:2,自引:0,他引:2
OBJECTIVES: This study investigates posttraumatic stress disorder (PTSD) and its associated risk factors in a random, national, Canadian sample of United Nations peacekeeping veterans with service-related disabilities. METHODS: Participants included 1016 male veterans (age < 65 years) who served in the Canadian Forces from 1990 to 1999 and were selected from a larger random sample of 1968 veterans who voluntarily and anonymously completed a general health survey conducted by Veterans Affairs Canada in 1999. Survey instruments included the PTSD Checklist-Military Version (PCL-M), Center for Epidemiological Studies-Depression Scale (CES-D), and questionnaires regarding life events during the past year, current stressors, sociodemographic characteristics, and military history. RESULTS: We found that rates of probable PTSD (PCL-M score > 50) among veterans were 10.92% for veterans deployed once and 14.84% for those deployed more than once. The rates of probable clinical depression (CES-D score > 16) were 30.35% for veterans deployed once and 32.62% for those deployed more than once. We found that, in multivariate analyses, probable PTSD rates and PTSD severity were associated with younger age, single marital status, and deployment frequency. CONCLUSIONS: PTSD is an important health concern in the veteran population. Understanding such risk factors as younger age and unmarried status can help predict morbidity among trauma-exposed veterans. 相似文献
955.
Abstract Migraine without aura is typically considered a female condition. The purpose of this study was to determine if there have
been any changes in the female-to-male ratio of the disease over time. We included in the study all patients with migraine
without aura (n=3457) referred to the Parma University Headache Centre between 1976 and 1995. They were divided into subgroups with respect
to gender and year-range of onset of migraine (before 1960, in the 1960s, in the 1970s, in the 1980s, and between 1990 and
1995). Gender ratio ranged from 3.6:1 (in patients with onset before 1960) to 2.8:1 (in patients with onset in the 1980s),
with no statistically significant changes during the observation period. 相似文献
956.
Social phobia, fear of negative evaluation and harm avoidance. 总被引:1,自引:0,他引:1
M Faytout J Tignol J Swendsen D Grabot B Aouizerate J P Lépine 《European psychiatry》2007,22(2):75-79
This naturalistic, prospective investigation examined the role of fear of negative evaluation and the personality trait of harm avoidance in the anxiety levels of treated social phobia patients. One hundred and fifty-seven patients with DSM-IV social phobia were assessed before starting treatment and were then followed for up to two years. As expected, greater fear of negative evaluation and higher scores of harm avoidance were associated with greater anxiety at the 6 month follow-up, and harm avoidance remained a significant predictor at 24 months. However, no evidence was found for an interaction between the personality and cognitive variables examined. The findings are discussed in terms of the relative independence of these factors, as well as their potential implications for the treatment of this disorder. 相似文献
957.
958.
妊娠性肝内胆汁淤积症(ICP)的主要特征是:母体难以忍受的瘙痒症,血清胆汁酸升高(≥10μmol/L)以及胎儿死亡风险的增加。最近,确定了一个与影响胎儿损害相关的界值,即血清胆汁酸≥40μmol/L。在一项双盲、安慰剂对照试验中,作研究了熊脱氧胆酸(UDCA)和地塞米松对瘙痒症、胆汁淤积的生化指标和胎儿并发症发生率的影响。为此,选取了130例患有ICP的妇女,随机分到UDCA组(1g/d,使用3周),地塞米松组(12mg/d使用1周,第2周、第3周使用安慰剂)和安慰剂组(使用3周)进行治疗。在治疗期间和治疗3周后对瘙痒症和胆汁淤积的生化指标进行分析。在分娩时记录胎儿的并发症(自发性早产,新生儿窒息,羊水、胎盘、胎膜的胎粪染色)。意向治疗分析显示仅在UDCA组中,丙氨酸转氨酶(ALT)(P=0.01)和胆红素(P=0.002)明显减少。在血清胆汁酸≥40μmol/L的ICP妇女的亚群分析中发现(n=34)UDCA对瘙痒症(减轻75%)、胆汁酸(下降79%)、ALT(降低80%)和胆红素(降低50%)也有明显效果,但对胎儿并发症发生率无影响。地塞米松并无减轻瘙痒症或降低ALT的作用,在降低胆汁酸和胆红素方面比UDCA效果差。 相似文献
959.
Kelboek H Thuesen L Helqvist S 《世界核心医学期刊文摘》2006,2(5):53-54
目的:SCANDSTENT试验旨在评价西罗莫司洗脱支架(SES)在复杂冠状动脉病变中的应用。背景:与裸金属支架(BMS)相比,在简单冠状动脉病变中使用SES能够改善造影和临.床的结果,但是,有关在复杂病变中使用SES的安全性和有效性的证据有限。方法:322例有症状的复杂冠状动脉疾病患者被随机分配接受SES或BMS治疗。病变形态分别为全闭(36%)、分叉(34%)、开口(22%)或成角(8%)改变。主要终点为支架置入6个月后血管最小管腔直径的差别。 相似文献
960.