Care in place: A case study of assembling a carescape

In this article we analyse the process of the multiple ways place and care shape each other and are co‐produced and co‐functioning. The resulting emerging assemblage of this co‐constituent process we call a carescape. Focusing on a case study of a nursing home on a Dutch island, we use place as a theoretical construct for analysing how current changes in healthcare governance interact with mundane practices of care. In order to make the patterns of care in our case explicit, we use actor‐network theory (ANT) sensibilities and especially the concept of assemblage. Our goal is to show – by zooming in on a particular case – how to study the co‐constituent processes of place‐ and care‐shaping, revealing the ontological diversity of place and care. Through this, we contribute a perspective of the heterogeneity and multiplicity of care in its dynamic relationship of co‐production with place.     

Morphogenesis of early stages of periodontal inflammations

Morphological signs of dissemination of active inflammatory process beyond the gingiva into the depth of the alveolar process bone tissue, paralleled by numerous destructive changes (bone resorption and lysis of collagen fibers of the periodontal ligament, plunged into the bone) in the periodontium are observed during clinically manifest chronic gingivitis. Hence, in contrast to the concept universally acknowledged in periodontology, despite the seeming clinical "heterogeneity" of gingivitis and periodontitis, these conditions should be regarded as a periodontal inflammation, because, judging by the detected morphological picture, each of the nosological entities acknowledged today (chronic gingivitis, periodontitis) represents just a successive stage of the same chronic inflammatory process differing only quantitatively but not qualitatively.     

Permutation and Bootstrap Testing for the Sequential Parallel Comparison Design

Sequential parallel comparison design (SPCD) was proposed to reduce placebo response in randomized trials with placebo comparators. This design is achieved by randomizing subjects between placebo and drug in stage 1 and after the parallel first stage, participants who do not respond to placebo in stage 1 are randomly re-assigned to treatment or placebo in stage 2. The efficacy analysis of the study data includes all data from stage 1 and all placebo nonresponding participants from stage 2. This article examines the validity of permutation and bootstrap testing for SPCD. We examine two permutation tests and three bootstrap tests for SPCD and give recommendations on which test to use.     

Comparative Evaluation of Antiparkinsonian,Anti-Inflammatory,and Analgesic Effects of Hemantane and Two 2-Aminoadamantane Derivatives Differing From it by a Bridgehead Hydroxyl

Pharmaceutical Chemistry Journal - 2-Adamantylaminopropanol hydrochloride (ADK-971) and 5-hydroxyadamantan-2-ylaminopropanol hydrochloride (ADK-1013) were less active than hemantane in parkinsonian...