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141.
142.
143.
Isabell Waldmann Fereydoun Vakilzadeh 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1997,48(9):666-670
Zusammenfassung
Allergische Reaktionen auf Farbstoffe in T?towierungen sind vergleichsweise selten. In der Mehrzahl sind es Reaktionen auf
die roten Farbstoffe. W?hrend früher haupts?chlich Quecksilberverbindungen (Zinnober) und Cadmiumsulfid dafür verantwortlich
waren, stehen heute die synthetischen anorganischen Azofarbstoffe im Vordergrund. Es wird ein 42j?hriger Mann mit allergischer
Reaktion in seinen roten T?towierungsanteilen vorgestellt. Histologisch imponierte eine chronisch verlaufende granulomat?se,
teils fibrosierende Entzündung mit transfollikul?rer Elimination von Pigmentgranula. Klinisch zeigte sich im Verlauf spontan
eine partielle Rückbildung der entzündlichen Ver?nderungen unter gleichzeitiger Depigmentierung und Vernarbung der Haut. Als
T?towierungsfarbstoff wurde ein aromatischer Azofarbstoff nachgewiesen. Neben der positiven Hauttestreaktion auf diesen Farbstoff
zeigte der Patient zus?tzlich eine positive Testreaktion auf den Textilfarbstoffkoppler Napthol AS.
Eingegangen am 23. August 1996 Angenommen am 15. November 1996 相似文献
144.
CX3CR1‐dependent recruitment of mature NK cells into the central nervous system contributes to control autoimmune neuroinflammation
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Laura Hertwig Isabell Hamann Silvina Romero‐Suarez Jason M. Millward Rebekka Pietrek Coralie Chanvillard Hanna Stuis Karolin Pollok Richard M. Ransohoff Astrid E. Cardona Carmen Infante‐Duarte 《European journal of immunology》2016,46(8):1984-1996
Fractalkine receptor (CX3CR1)‐deficient mice develop very severe experimental autoimmune encephalomyelitis (EAE), associated with impaired NK cell recruitment into the CNS. Yet, the precise implications of NK cells in autoimmune neuroinflammation remain elusive. Here, we investigated the pattern of NK cell mobilization and the contribution of CX3CR1 to NK cell dynamics in the EAE. We show that in both wild‐type and CX3CR1‐deficient EAE mice, NK cells are mobilized from the periphery and accumulate in the inflamed CNS. However, in CX3CR1‐deficient mice, the infiltrated NK cells displayed an immature phenotype contrasting with the mature infiltrates in WT mice. This shift in the immature/mature CNS ratio contributes to EAE exacerbation in CX3CR1‐deficient mice, since transfer of mature WT NK cells prior to immunization exerted a protective effect and normalized the CNS NK cell ratio. Moreover, mature CD11b+ NK cells show higher degranulation in the presence of autoreactive 2D2 transgenic CD4+ T cells and kill these autoreactive cells more efficiently than the immature CD11b? fraction. Together, these data suggest a protective role of mature NK cells in EAE, possibly through direct modulation of T cells inside the CNS, and demonstrate that mature and immature NK cells are recruited into the CNS by distinct chemotactic signals. 相似文献
145.
Results of a 2‐arm,phase 2 clinical trial using post‐transplantation cyclophosphamide for the prevention of graft‐versus‐host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation
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![点击此处可从《Cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sameh Gaballa MD MSc Isabell Ge Riad El Fakih MD Jonathan E. Brammer MD Piyanuch Kongtim MD Ciprian Tomuleasa MD Sa A. Wang MD Dean Lee MD PhD Demetrios Petropoulos MD Kai Cao MS MD Gabriela Rondon MD Julianne Chen BS Aimee Hammerstrom PharmD Lindsey Lombardi PharmD Gheath Alatrash DO PhD Martin Korbling MD Betul Oran MD Partow Kebriaei MD Sairah Ahmed MD Nina Shah MD Katayoun Rezvani MD PhD David Marin MD DM MSc Qaiser Bashir MD Amin Alousi MD Yago Nieto MD PhD Muzaffar Qazilbash MD Chitra Hosing MD Uday Popat MD Elizabeth J. Shpall MD Issa Khouri MD Richard E. Champlin MD Stefan O. Ciurea MD 《Cancer》2016,122(21):3316-3326
146.
Strassmann G Braun I Kress O Richter D Neidel HO Klose KJ An H Vogel B Rose F Engenhart-Cabillic R 《International journal of radiation oncology, biology, physics》2006,66(2):576-582
BACKGROUND: This study is situated in the area of measuring set-up accuracy and time periods of single-session extracranial radiotherapy (SSRT) for simple-shaped targets (e.g., spherical or rotational symmetrical) definitively located in the peripheral lung. METHODS AND MATERIALS: After adaptation of the stereotactic body frame, the patient has to remain in the vacuum pillow during planning computed tomography (CT), fast three-dimensional (3-D) treatment planning, and direct irradiation after verification. Fast preplanning is performed by using virtual simulation software to accelerate the method. RESULTS: In our new procedure, SSRT is applied in approximately 1.5 h. The mean setup accuracy vector was 2.4+/-0.7 mm in the range of 1.34 to 4 mm. Mean intrafractional patient movement in the stereotactic body frame before and after radiation was 0.70 mm+/-0.5 mm and 0.76+/-0.76 mm in the range of 0 to 2.8 mm. Mean time period steps were measured at (1) planning CT with 3-D treatment planning: 76+/-12 min; (2) irradiation and verification: 33+/-7 min; and (3) complete procedure duration: 109+/-11 min (range, 89-169). CONCLUSIONS: The main difference between the positioning technique of SSRT and that of conventional extracranial radiosurgery is the tighter patient fixation, which guarantees minimal patient movement. The main advantages are procedure acceleration and omission of CT simulation. SSRT is a preliminary stage of real-time treatment. 相似文献
147.
Allgeier C Kämmerle-Hofrichte I Braun S Heimann K Lauffer-Spindler B Leinweber R Scherzer A Schulz K Thiele K Wulfgramm H 《Pflege》2005,18(6):373-380
The study "determining the support needs of patients who live at home following a stroke" was chosen because stroke is (one of) the most significant causes of permanent handicap in the elderly. (This project was developed as part of the studies for the degree of Nurse Manager/Teacher:) The results are based on qualitative and quantitative data collected from focus groups and a standardised questionnaire. Due to the small number of participants (57) the study cannot be regarded as representative. Typical key issues such as "going out of the house" were highlighted in the standard questionnaires. The interviews which were evaluated using the Mayring technique give an impression of themes, such as reduced tolerance levels and (greater) increased anxiety, which together with the physical burden dominate their daily life. It was apparent that the persons concerned have a general lack of understanding of their condition. The most significant results of the study are presented together with life enhancing recommendations. 相似文献
148.
Mathias Bergmann Anke Post Isabell Rittel Ingo Bechmann R. Nitsch 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,117(1):80-86
Expression of the synaptic vesicle protein synaptophysin was studied in lesion-induced sprouting neurons of the contralateral
entorhinal cortex and in the contralateral dentate gyrus using immunocytochemistry at the light- and electron-microscopic
level. Perikaryal immunoreactivity for synaptophysin was found between 8 and 10 days postlesion. Light microscopy revealed
that synaptophysin immunostaining was present in almost all neurons of layers II and III of the contralateral medial entorhinal
cortex. These neurons give rise to the sprouting, crossed temporodentate pathway. In addition, some hilar neurons of the contralateral
dentate gyrus, which are the parent cells of sprouting commissural fibers, were immunostained for synaptophysin. Transient
immunostaining for synaptophysin was observed within cell bodies and dendrites. Additionally, the cell bodies were outlined
by immunoreactive puncta, identified by electron microscopy as nerve terminals. Our results revealed that sprouting neurons
express the major synaptic vesicle protein synaptophysin during reactive synaptogenesis in a pattern that reflects biosynthesis
and sorting of this protein as seen in developing neurons during synapse formation.
Received: 13 November 1996 / Accepted: 3 June 1997 相似文献
149.
Ultrasound-accelerated formalin fixation of tissue improves morphology, antigen and mRNA preservation. 总被引:1,自引:0,他引:1
Wei-Sing Chu Bungo Furusato Kondi Wong Isabell A Sesterhenn Fathollah K Mostofi Min Qi Wei Zhenqing Zhu Susan L Abbondanzo Qi Liang 《Modern pathology》2005,18(6):850-863
Formalin fixation and paraffin embedding are conventional tissue preservation and processing methods used for histologic diagnosis in over 90% of cases. However, formalin fixation has three disadvantages: (1) slow fixation (16-24 h) hinders intraoperative decision making, (2) slow quenching of enzymatic activity causes RNA degradation, and (3) extensive molecule modification affects protein antigenicity. Applying high-frequency, high-intensity ultrasound to the formalin fixative cuts fixation time to 5-15 min. Fixation of various tissues such as lymph node, brain, breast, and prostate suggests that, compared to the conventional method, implementation of ultrasound retains superior and more uniform tissue morphology preservation. Less protein antigenicity is altered so that rapid immunohistochemical reactions occur with higher sensitivity and intensity, reducing the need for antigen retrieval pretreatment. Better RNA preservation results in stronger signals in in situ hybridization and longer RNA fragments extracted from fixed tissues, probably due to rapid inhibition of endogenous RNase activity. Molecules extracted from ultrasound-fixed tissues are of greater integrity and quantity compared to conventionally fixed tissues, and thus better support downstream molecular analyses. Overall, ultrasound-facilitated tissue preservation can provide rapid and improved morphological and molecular preservation to better accommodate both traditional and molecular diagnoses. 相似文献
150.
John J. Bauer Isabell A. Sesterhenn F.K. Mostofi David G. McLeod Shiv Srivastava Judd W. Moul 《The Journal of urology》1996,156(4):1511-1516