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排序方式: 共有303条查询结果,搜索用时 15 毫秒
101.
Lidia Del Piccolo Hanneke de HaesCathy Heaven Jesse Jansen William VerheulJozien Bensing Svein BergvikMyriam Deveugele Hilde EideIan Fletcher Claudia GossGerry Humphris Young-Mi KimWolf Langewitz Maria Angela MazziTrond Mjaaland Francesca MorettiMatthias Nübling Michela RimondiniPeter Salmon Tonje SibbernIngunn Skre Sandra van DulmenLarry Wissow Bridget YoungLinda Zandbelt Christa ZimmermannArnstein Finset 《Patient education and counseling》2011,82(2):149-155
102.
Forchhammer L Loft S Roursgaard M Cao Y Riddervold IS Sigsgaard T Møller P 《Toxicology letters》2012,209(2):121-128
Toxicological effects of wood smoke particles are less investigated than traffic-related combustion particles. We investigated the effect of wood smoke particles, generated by smouldering combustion conditions, on human umbilical endothelial cells (HUVECs) co-cultured with or without monocytic THP-1 cells. Standard reference material (SRM) 2975 diesel exhaust particles were used as benchmark particles. Wood smoke particles at 50 μg/ml or 100 μg/ml caused adhesion of THP-1 monocytes onto HUVECs in co-cultures, whereas SRM2975 had no such effect. Both types of particles from 1 μg/ml increased VCAM-1 expression on HUVECs in mono-cultures. However, only the exposure to wood smoke particles was associated with increased expression of TNF and IL8 mRNA in THP-1 cells. We found no effect on the intracellular production of reactive oxygen species by the fluorescent probe DCFH-DA, whereas especially the wood smoke particles caused increased level of DNA strand breaks and oxidised guanines at concentrations with low cytotoxicity. In conclusion, our results indicate that the adherence of monocytes on endothelial cells in wood smoke particle exposed cultures depend on activation of both cell types. 相似文献
103.
Mannelqvist M Stefansson IM Bredholt G Hellem Bø T Oyan AM Jonassen I Kalland KH Salvesen HB Akslen LA 《The American journal of pathology》2011,178(2):861-871
The presence of tumor cells entering vascular channels is a prognostic marker for many cancers, including endometrial carcinoma. Vascular invasion is considered to be an early step in the metastatic process and important for the progress of malignant tumors. Here, we investigated the gene expression patterns related to vascular involvement in 57 primary endometrial cancers, using DNA microarray and quantitative PCR techniques. A vascular invasion signature of 18 genes was significantly associated with patient survival and clinicopathological phenotype. Vascular involvement was also related to gene sets for epithelial-mesenchymal transition, wound response, endothelial cells, and vascular endothelial growth factor (VEGF) activity. With immunohistochemical validation, both collagen 8 and matrix metalloproteinase 3 (MMP3) were associated with vascular invasion, whereas ANGPTL4 and IL-8 were associated with patient survival. Our findings indicate that vascular involvement within primary tumors is associated with gene expression profiles related to angiogenesis and epithelial-mesenchymal transition. These data could contribute to an improved understanding of potential targets for metastatic spread and may provide clinically important information for better management of endometrial cancer. 相似文献
104.
Skre I Onstad S Torgersen S Philos DR Lygren S Kringlen E 《Journal of anxiety disorders》2000,14(6):549-562
The aim of this study was to investigate the genetic and environmental contribution to common phobic fears, and to relate the findings to contemporary theories about the etiology of common phobic fears. Self-reported common phobic fear was studied in a treatment sample of 23 monozygotic and 38 same-sex dizygotic twin pairs. Heritability of .47 was observed for common phobic fear of small animals and social fear, and a heritability of .30 in common agoraphobic fear. For common fear of nature phenomena and situational fear, the heritability was 0. The finding that common nature and situational fears were solely caused by environmental factors is in support of learning theory, whereas results for animal, social, and other common phobic fear are in support of an integrative theory of biological preparedness, learning history, and a cognitive style of fearful expectation. 相似文献
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107.
Robert E. Coleman Allan Lipton G. David Roodman Theresa A. Guise Brendon F. Boyce Adam M. Brufsky Philippe Clézardin Peter I. Croucher Julie R. Gralow Peyman Hadji Ingunn Holen Gregory R. Mundy Matthew R. Smith Larry J. Suva 《Cancer treatment reviews》2010
Tumor metastasis to the skeleton affects over 400,000 individuals in the United States annually, more than any other site of metastasis, including significant proportions of patients with breast, prostate, lung and other solid tumors. Research on the bone microenvironment and its role in metastasis suggests a complex role in tumor growth. Parallel preclinical and clinical investigations into the role of adjuvant bone-targeted agents in preventing metastasis and avoiding cancer therapy-induced bone loss have recently reported exciting and intriguing results. A multidisciplinary consensus conference convened to review recent progress in basic and clinical research, assess gaps in current knowledge and prioritize recommendations to advance research over the next 5 years. The program addressed three topics: advancing understanding of metastasis prevention in the context of bone pathophysiology; developing therapeutic approaches to prevent metastasis and defining strategies to prevent cancer therapy-induced bone loss. Several priorities were identified: (1) further investigate the effects of bone-targeted therapies on tumor and immune cell interactions within the bone microenvironment; (2) utilize and further develop preclinical models to study combination therapies; (3) conduct clinical studies of bone-targeted therapies with radiation and chemotherapy across a range of solid tumors; (4) develop biomarkers to identify patients most likely to benefit from bone-targeted therapies; (5) educate physicians on bone loss and fracture risk; (6) define optimal endpoints and new measures of efficacy for future clinical trials; and (7) define the optimum type, dose and schedule of adjuvant bone-targeted therapy. 相似文献
108.
Lars T Fadnes Ingunn MS Engebretsen Henry Wamani Jonathan Wangisi James K Tumwine Thorkild Tylleskär 《BMC pediatrics》2009,9(1):2-11
Background
The choice of infant feeding method is important for HIV-positive mothers in order to optimise the chance of survival of their infants and to minimise the risk of HIV transmission. The aim of this study was to investigate feeding practices, including breastfeeding, in the context of PMTCT for infants and children under two years of age born to HIV-positive mothers in Uganda. 相似文献109.
Margaret Wandera Ingunn MS Engebretsen Isaac Okullo James K Tumwine Anne N Åstrøm 《BMC oral health》2009,9(1):18-11
Background
Information on the socio-behavioral distribution of periodontal status and tooth loss in pregnancy emanating from sub Saharan Africa is sparse. This study examined periodontal status and tooth loss in pregnant Ugandan women and assessed the relationship with socio-demographics factors, parity, dental care and oral hygiene. 相似文献110.
Helle Wessel Andersson Johan Håkon Bjørngaard Silje Lill Kaspersen Catharina E. A. Wang Ingunn Skre Thomas Dahl 《Social psychiatry and psychiatric epidemiology》2010,45(5):569-577