全文获取类型
收费全文 | 2591篇 |
免费 | 130篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 37篇 |
妇产科学 | 26篇 |
基础医学 | 385篇 |
口腔科学 | 67篇 |
临床医学 | 143篇 |
内科学 | 745篇 |
皮肤病学 | 30篇 |
神经病学 | 331篇 |
特种医学 | 63篇 |
外科学 | 292篇 |
综合类 | 6篇 |
预防医学 | 49篇 |
眼科学 | 26篇 |
药学 | 274篇 |
中国医学 | 5篇 |
肿瘤学 | 222篇 |
出版年
2023年 | 14篇 |
2022年 | 26篇 |
2021年 | 55篇 |
2020年 | 32篇 |
2019年 | 42篇 |
2018年 | 51篇 |
2017年 | 27篇 |
2016年 | 35篇 |
2015年 | 46篇 |
2014年 | 58篇 |
2013年 | 59篇 |
2012年 | 126篇 |
2011年 | 111篇 |
2010年 | 70篇 |
2009年 | 54篇 |
2008年 | 100篇 |
2007年 | 113篇 |
2006年 | 111篇 |
2005年 | 117篇 |
2004年 | 100篇 |
2003年 | 109篇 |
2002年 | 107篇 |
2001年 | 73篇 |
2000年 | 103篇 |
1999年 | 86篇 |
1998年 | 24篇 |
1997年 | 21篇 |
1996年 | 15篇 |
1995年 | 13篇 |
1994年 | 25篇 |
1993年 | 19篇 |
1992年 | 91篇 |
1991年 | 59篇 |
1990年 | 73篇 |
1989年 | 63篇 |
1988年 | 57篇 |
1987年 | 65篇 |
1986年 | 60篇 |
1985年 | 44篇 |
1984年 | 31篇 |
1983年 | 31篇 |
1982年 | 28篇 |
1981年 | 18篇 |
1979年 | 18篇 |
1978年 | 11篇 |
1974年 | 11篇 |
1973年 | 19篇 |
1972年 | 11篇 |
1968年 | 13篇 |
1967年 | 13篇 |
排序方式: 共有2729条查询结果,搜索用时 31 毫秒
71.
Kikuchi M Inagaki T Ueda R 《Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics》2004,41(4):420-425
A 91-year-old woman was hospitalized with acute respiratory distress syndrome due to pneumonia in June 1997. Since she had pancytopenia and a bone marrow aspirate indicated hypocellularity with no increase in myeloblasts, dysplasia or abnormal chromosomes, aplastic anemia (AA) was diagnosed. Pulse therapy with methylprednisolone and antibiotics proved successful, and blood cell numbers stabilized. In June 2001, she was readmitted to our hospital with persistent low grade fever and leukopenia. A bone marrow aspirate from the sternum and iliac bone biopsy revealed compact proliferation of small lymphocytes, and the surface marker CD5- CD10- CD11c+ CD19+ CD20+ CD23- was detected through immune staining and flowcytometry. CD30+, CD34+and CD56+cells were scarce. Tests for surface immunoglobulins, IgG, IgA, IgM and IgD, were negative. No nodal or extranodal lesions were evident. Since Southern blot analysis of bone marrow cells indicated rearrangement of the immunoglobulin heavy chain and abnormal chromosomes were evident, small lymphocytic lymphoma (SLL) was diagnosed. Four intravenous infusions of rituximab (375mg/m2) were administered without critical adverse effects. Tests conducted four weeks later revealed saturation of CD20+ antigens of lymphoma cells and chromosomal abnormalities and rearrangement of the immunoglobulin heavy chain were still apparent. Though complete remission of the pancytopenia was not achieved, serum concentrations of lactate dehydrogenase and soluble interleukin-2 receptor decreased, and the numbers of platelets and erythrocytes increased. There was also an improvement in systemic condition. This was a rare case of SLL having the surface marker of CD5- CD10- CD11c+ CD19+ CD20+ CD23-, which had evolved from AA and infiltrated bone marrow. 相似文献
72.
73.
T Mashito I Takada T Kenbo A Watanabe K Himuro K Inagaki 《Nippon Naibunpi Gakkai zasshi》1979,55(2):89-95
HGH secretion in response to TRH was studied in patients with cerebrovascular disease in order to elucidate an influence of cerebrovascular lesions on the hypothalamus-anterior pituitary function. Blood specimens were obtained before and at the time of 10, 20, 30, 40, 60, 90 and 120 minutes after the intraveneous administration of 200 microgram of TRH in 17 patients with cerebral hemorrhage and in 8 patients with cerebral infarction. With regards to the natural fluctuations of serum HGH caused by cerebrovascular disease, the blood specimens were obrained at the time of 0, 30, 60, 90 and 120 minutes without the administration of TRH in 4 patients with cerebral hemorrhage and in 4 patients with cerebral infarction. Serum HGH was measured using the RIA method and the following results were obtained: 1) An increase in serum HGH was observed in 1 patient with cerebral hemorrhage out of 8 patients with cerebrovascular disease without TRH administration. 2) In 5 out of 17 patients with cerebral hemorrhage, an increase in serum HGH was observed following TRH administration. Three out of these 5 patients were included in the group of non-coma, and 4 out of the 5 patients were female. 3) In 2 out of 8 patients with cerebral infarction, an increase in serum HGH was observed following TRH administration. 相似文献
74.
Riyo Ueda Yoshimi Kaga Yosuke Kita Miho Tanaka Masaki Iwasaki Eri Takeshita Yuko Shimizu-Motohashi Akihiko Ishiyama Takashi Saito Eiji Nakagawa Kenji Sugai Masayuki Sasaki Takashi Okada Masumi Inagaki 《Brain & development》2021,43(2):280-287
IntroductionAn alteration in postoperative cognitive function varies according to the patients’ background characteristics, such as etiology, focus, and seizure duration. Accurate prediction and assessment of postoperative cognitive function is difficult in each patient. Adaptive behavior could describe the typical performance of daily activities and represents the ability to translate cognitive potential into real-world skills. We examined the relationship between alterations of executive function (EF) and adaptive behavior in school children undergoing surgery for intractable epilepsy.MethodologyWe enrolled 31 children with focal resection or corpus callosotomy for intractable epilepsy [mean age at surgery, 12.5 years; 16 boys; mean intellectual quotient, 73.3]. We surveyed answered questionnaires on attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and adaptive behavior using the Vineland Adaptive Behavior Scale, 2nd edition (VABS-II), and performed continuous performance tests (CPTs) on children pre- and postoperatively.ResultADHD and ASD symptoms improved after epilepsy surgery. The omission error (OE) in the CPT variable improved after epilepsy surgery, especially in children with a shorter preoperative period. Improved ASD symptoms led to an increased score of the coping skills subdomain. The reduced OE observed after surgery also increased the score of the community skills subdomain.ConclusionImprovement in EF and ASD symptoms resulted in better adaptive behavior postoperatively. These results were important for the pre- and postoperative evaluation and re-evaluation of children with epilepsy requiring special education and related services. 相似文献
75.
76.
77.
78.
79.
Haruka Fujita Takaaki Murakami Fumiaki Tomoike Daisuke Yabe Nobuya Inagaki 《Journal of diabetes investigation.》2020,11(3):726-730
Genetic rearrangements of anaplastic lymphoma kinase contribute to the pathogenesis of non‐small‐cell lung cancer; the anaplastic lymphoma kinase inhibitor, ceritinib, is widely used, as it is effective even in patients with non‐small‐cell lung cancer resistant to other anaplastic lymphoma kinase inhibitors. Although a case of possible ceritinib‐induced hyperglycemia was reported, the association of ceritinib with hyperglycemia remains to be investigated. Disproportionality analysis was carried out using the Japanese Adverse Drug Event Report database, which contains all pharmacovigilance data based on spontaneous reports of adverse events between April 2004 and November 2018 to the Pharmaceuticals and Medical Devices Agency. The reporting odds ratio of ceritinib for hyperglycemia was 2.25 (95% confidence interval [CI] 1.24–4.08], whereas those of crizotinib and alectinib were 0.07 (95% CI 0.01–0.40) and 0.94 (95% CI 0.30–2.94), respectively. Among reported events without antidiabetes agent use, the reporting odds ratio of ceritinib was still 2.54 (95% CI 1.27–5.12). Thus, the possibility of hyperglycemia should be carefully monitored in patients receiving ceritinib. 相似文献
80.
Sae Aoyama‐Sasabe Xin Xin Ataru Taniguchi Yoshikatsu Nakai Rie Mitsui Hideaki Tsuji Daisuke Yabe Koichiro Yasuda Takeshi Kurose Nobuya Inagaki Yutaka Seino Mitsuo Fukushima 《Journal of diabetes investigation.》2014,5(6):663-670