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排序方式: 共有302条查询结果,搜索用时 375 毫秒
61.
Ilenia Folletti Jan-Paul Zock Gianna Moscato Andrea Siracusa 《The Journal of asthma》2014,51(1):18-28
Objective: This article presents a systematic review of epidemiological studies linking cleaning work and risk of asthma and rhinitis. Methods: Published reports were identified from PubMed covering the years from 1976 through June 30, 2012. In total, we identified 24 papers for inclusion in the review. The quality of studies was evaluated using the Strengthening of the Reporting of Observational Studies in Epidemiology (STROBE) statement checklist of 22 items for cross-sectional, cohort and case–control studies. Results: Increased risk of asthma or rhinitis has been shown in 79% of included epidemiological studies. In four studies the increased risk of asthma in cleaning workers was confirmed by objective tests, such as bronchial hyper-reactivity or airflow obstruction. Level of exposure to cleaning products, cleaning sprays, bleach, ammonia, mixing products and specific job tasks has been identified as specific causes of asthma and rhinitis. Conclusions: Possible preventive measures encompass the substitution of cleaning sprays, bleach and ammonia, avoidance of mixing products, the use of respiratory protective devices, worker education and medical surveillance. 相似文献
62.
Giuseppe Mannino Fabio Caradonna Ilenia Cruciata Antonino Lauria Anna Perrone Carla Gentile 《Journal of pineal research》2019,67(3)
Melatonin is the main secretory product of the pineal gland, and it is involved in the regulation of periodic events. A melatonin production independent of the photoperiod is typical of the gut. However, the local physiological role of melatonin at the intestinal tract is poorly characterized. In this study, we evaluated the anti‐inflammatory activities of melatonin in an in vitro model of inflamed intestinal epithelium. To this purpose, we assessed different parameters usually associated with intestinal inflammation using IL‐1β‐stimulated Caco‐2 cells. Differentiated monolayers of Caco‐2 cells were preincubated with melatonin (1 nmol/L‐50 μmol/L) and then exposed to IL‐1β. After each treatment, different inflammatory mediators, DNA‐breakage, and global DNA methylation status were assayed. To evaluate the involvement of melatonin membrane receptors, we also exposed differentiated monolayers to melatonin in the presence of luzindole, a MT1 and MT2 antagonist. Our results showed that melatonin, at concentrations similar to those obtained in the lumen gut after ingestion of dietary supplements for the treatment of sleep disorders, was able to attenuate the inflammatory response induced by IL‐1β. Anti‐inflammatory effects were expressed as both a decrease of the levels of inflammatory mediators, including IL‐6, IL‐8, COX‐2, and NO, and a reduced increase in paracellular permeability. Moreover, the protection was associated with a reduced NF‐κB activation and a prevention of DNA demethylation. Conversely, luzindole did not reverse the melatonin inhibition of stimulated‐IL‐6 release. In conclusion, our findings suggest that melatonin, through a local action, can modulate inflammatory processes at the intestinal level, offering new opportunities for a multimodal management of IBD. 相似文献
63.
Giorgio Leodori MD PhD Maria Ilenia De Bartolo MD Andrea Guerra MD PhD Andrea Fabbrini MD Lorenzo Rocchi MD PhD Anna Latorre MD PhD Giulia Paparella MD PhD Daniele Belvisi MD PhD Antonella Conte MD PhD Kailash P. Bhatia FRCP MD John C. Rothwell PhD Alfredo Berardelli MD 《Movement disorders》2022,37(4):734-744
64.
Cristillo Viviana Pilotto Andrea Benussi Alberto Libri Ilenia Giunta Marcello Morotti Andrea Gipponi Stefano Locatelli Martina Piccinelli Stefano Cotti Mazzoleni Valentina di Cola Francesca Schiano Masciocchi Stefano Pezzini Debora Scalvini Andrea Premi Enrico Cottini Elisabetta Gamba Massimo Magoni Mauro Fontanella Marco Maria Padovani Alessandro 《Neurological sciences》2022,43(5):2923-2927
Neurological Sciences - The aim of this study is to evaluate the differences in clinical presentations and the impact of healthcare organization on outcomes of neurological COVID-19 patients... 相似文献
65.
Mariniello Arianna Schiavolin Silvia Magnani Francesca Cristillo Viviana Piccinelli Stefano Cotti Zoppi Nicola Bonzi Giulio Sattin Davide Silvaggi Fabiola Raggi Alberto Cacciatore Martina Guastafierro Erika Toppo Claudia Gipponi Stefano Libri Ilenia Bezzi Michela Leonardi Matilde Pilotto Andrea Padovani Alessandro 《Neurological sciences》2022,43(4):2187-2193
Neurological Sciences - Several people affected by COVID-19 experienced neurological manifestations, altered sleep quality, mood disorders, and disability following hospitalization for a long time.... 相似文献
66.
Plasma or serum samples: measurements of cardiac troponin T and of other analytes compared. 总被引:1,自引:0,他引:1
Roberto Dominici Ilenia Infusino Cristina Valente Irene Moraschinelli Carlo Franzini 《Clinical chemistry and laboratory medicine》2004,42(8):945-951
Conflicting data in the literature concern possible differences in the immunochemical measurement of cardiac troponins, either in plasma or in serum. In order to address this specific point, 96 serum and heparin-plasma pairs were obtained for cardiac marker measurement [cardiac troponin T (cTnT); myoglobin (Myo) and creatine kinase-MB isoenzyme (CK-MB)]; 29 additional "common" analytes were measured in 77 such samples. The cardiac markers were measured by electrochemiluminescence (Elecsys 2010, Roche); the other analytes by established automated methods (Modular, Roche). Mean plasma/serum ratios for cTnT (0.95), creatine kinase-MB (1.01) and myoglobin (0.99) were comparable with those of the 29 common analytes (interval of means 0.83-1.05). The distribution of the plasma-serum differences also showed similarities between cardiac markers and other analytes. A few outlier plasma-serum differences (3-5%) were measured for both categories of analytes. Addition of heparin to serum (51 samples) caused decreased cTnT (mean ratio 0.92). In 3 of 51 such samples the cTnT decrease was more marked, but in a second sample from the same subjects (1 week later) such a prominent, heparin-induced loss of cTnT no longer appeared. In conclusion, plasma-serum differences in immuno-reactive cTnT compare with those observed for other analytes. In occasional heparin-plasma samples immunochemical measurement of cTnT may give exceptionally low values. However, in our sample group of 96 patients (cTnT lower or higher than the cut-off in, respectively, 24 and 72 patients), no misclassification occurred if plasma instead of serum cTnT values were considered. 相似文献
67.
Colaci Michele Dal Bosco Ylenia Schinocca Claudia Ronsivalle Giuseppe Guggino Giuliana De Andres Ilenia Russo Alessandra A. Sambataro Domenico Sambataro Gianluca Malatino Lorenzo 《Clinical rheumatology》2021,40(3):1185-1189
Clinical Rheumatology - Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction and fibroblasts activation. Microvascular disease may be easily observed by means... 相似文献
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