全文获取类型
收费全文 | 298篇 |
免费 | 9篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 7篇 |
妇产科学 | 12篇 |
基础医学 | 47篇 |
口腔科学 | 1篇 |
临床医学 | 31篇 |
内科学 | 87篇 |
皮肤病学 | 3篇 |
神经病学 | 36篇 |
特种医学 | 7篇 |
外科学 | 22篇 |
预防医学 | 11篇 |
眼科学 | 4篇 |
药学 | 18篇 |
肿瘤学 | 24篇 |
出版年
2024年 | 1篇 |
2023年 | 9篇 |
2022年 | 25篇 |
2021年 | 26篇 |
2020年 | 10篇 |
2019年 | 8篇 |
2018年 | 15篇 |
2017年 | 4篇 |
2016年 | 16篇 |
2015年 | 11篇 |
2014年 | 12篇 |
2013年 | 17篇 |
2012年 | 28篇 |
2011年 | 31篇 |
2010年 | 9篇 |
2009年 | 4篇 |
2008年 | 17篇 |
2007年 | 16篇 |
2006年 | 19篇 |
2005年 | 12篇 |
2004年 | 14篇 |
2003年 | 4篇 |
2002年 | 1篇 |
1998年 | 1篇 |
1996年 | 1篇 |
排序方式: 共有311条查询结果,搜索用时 15 毫秒
141.
142.
143.
Spears M Oesterreich S Migliaccio I Guiterrez C Hilsenbeck S Quintayo MA Pedraza J Munro AF Thomas JS Kerr GR Jack WJ Kunkler IH Cameron DA Chetty U Bartlett JM 《Breast cancer research and treatment》2012,131(2):463-472
The SRC family of ER co-regulators are frequently overexpressed in breast cancer. Overexpression of AIB1 appears to be linked to hormone resistance in HER2 positive breast cancer. However, the role of these co-regulators in ER negative disease is poorly understood. SRC1, SRC2 and AIB1 expression was determined by immunohistochemical analysis of tissue microarrays constructed from tumours within the Edinburgh Breast Conservation Series (BCS). The BCS represents a fully documented consecutive cohort of 1,812 patients treated by breast conservation surgery in a single institution. Our results demonstrate tumours that overexpress both HER2 and AIB1 were associated with markedly reduced relapse free, distant relapse free and overall survival compared to HER2 and AIB1 only overexpressing tumours irrespective of ER status. In ER negative disease both SRC1 and AIB1 were linked to early relapse and death. The SRC family of ER co-regulators is involved in early relapse and resistance in both ER negative and ER positive breast cancer challenging the conventional concept that this effect is mediated solely via the ER. 相似文献
144.
Di Cola Ilenia Bruno Federico Berardicurti Onorina Monti Riccardo Conforti Alessandro Di Sibio Alessandra Pavlych Viktoriya Masciocchi Carlo Barile Antonio Cipriani Paola Ruscitti Piero 《Clinical rheumatology》2021,40(10):3971-3978
Clinical Rheumatology - In this study, we aimed at describing the multivisceral involvement on adult-onset Still’s disease (AOSD) to retrieve imaging-based differences in patients with and... 相似文献
145.
Volcanic ash layers illuminate the resilience of Neanderthals and early modern humans to natural hazards 总被引:2,自引:0,他引:2
J Lowe N Barton S Blockley CB Ramsey VL Cullen W Davies C Gamble K Grant M Hardiman R Housley CS Lane S Lee M Lewis A Macleod M Menzies W Müller M Pollard C Price AP Roberts EJ Rohling C Satow VC Smith CB Stringer EL Tomlinson D White P Albert I Arienzo G Barker D Boric A Carandente L Civetta C Ferrier JL Guadelli P Karkanas M Koumouzelis UC Müller G Orsi J Pross M Rosi L Shalamanov-Korobar N Sirakov PC Tzedakis 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(34):13532-13537
Marked changes in human dispersal and development during the Middle to Upper Paleolithic transition have been attributed to massive volcanic eruption and/or severe climatic deterioration. We test this concept using records of volcanic ash layers of the Campanian Ignimbrite eruption dated to ca. 40,000 y ago (40 ka B.P.). The distribution of the Campanian Ignimbrite has been enhanced by the discovery of cryptotephra deposits (volcanic ash layers that are not visible to the naked eye) in archaeological cave sequences. They enable us to synchronize archaeological and paleoclimatic records through the period of transition from Neanderthal to the earliest anatomically modern human populations in Europe. Our results confirm that the combined effects of a major volcanic eruption and severe climatic cooling failed to have lasting impacts on Neanderthals or early modern humans in Europe. We infer that modern humans proved a greater competitive threat to indigenous populations than natural disasters. 相似文献
146.
147.
148.
149.
Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus 总被引:17,自引:0,他引:17
Fadini GP Miorin M Facco M Bonamico S Baesso I Grego F Menegolo M de Kreutzenberg SV Tiengo A Agostini C Avogaro A 《Journal of the American College of Cardiology》2005,45(9):1449-1457
OBJECTIVES: We sought to establish whether a reduction in endothelial progenitor cells (EPCs) has a putative role in peripheral vascular disease (PVD) of type 2 diabetic patients. BACKGROUND: Peripheral vascular disease is a common and severe complication of diabetes mellitus. Impaired collateralization of diabetic vasculopathy has been extensively shown, but causes leading to its pathogenesis are not fully understood. Recently, EPCs have been found to contribute to vascular repair and angiogenesis. Diabetes has been associated with low levels of circulating EPCs, but no data are available in the literature on the relationship between EPCs and PVD in diabetes. METHODS: Flow cytometric analysis was used to quantify circulating progenitor cells (CPCs, CD34+) and EPCs (CD34+KDR+) in 51 patients and 17 control subjects. RESULTS: The CPCs and EPCs from diabetic patients were reduced by 33% and 40%, respectively, compared with healthy subjects (p < 0.001). An inverse correlation was found between the number of EPCs and the values of fasting glucose (r = -0.49, p = 0.006). Peripheral vascular disease was associated with a 47% reduction in EPCs (p < 0.0001) and EPC levels directly correlated with the ankle-brachial index (r = 0.70, p = 0.01). The subgroup of diabetic patients with PVD also had reduced CPCs by 32% (p = 0.037), whereas patients with ischemic foot lesions had the lowest levels of both EPCs and CPCs (p = 0.02). CONCLUSIONS: Our data demonstrate decreased EPC levels in diabetic patients and, for the first time, show that PVD is associated with an extensively low number of EPCs. Depletion of circulating EPCs in diabetic patients may be involved in the pathogenesis of peripheral vascular complications. 相似文献
150.