全文获取类型
收费全文 | 228344篇 |
免费 | 4198篇 |
国内免费 | 598篇 |
专业分类
耳鼻咽喉 | 2088篇 |
儿科学 | 7207篇 |
妇产科学 | 3804篇 |
基础医学 | 25933篇 |
口腔科学 | 2875篇 |
临床医学 | 17008篇 |
内科学 | 40791篇 |
皮肤病学 | 2511篇 |
神经病学 | 20219篇 |
特种医学 | 11708篇 |
外科学 | 35803篇 |
综合类 | 2510篇 |
现状与发展 | 1篇 |
一般理论 | 17篇 |
预防医学 | 20640篇 |
眼科学 | 3894篇 |
药学 | 13997篇 |
中国医学 | 1247篇 |
肿瘤学 | 20887篇 |
出版年
2023年 | 429篇 |
2022年 | 1328篇 |
2021年 | 2061篇 |
2020年 | 987篇 |
2019年 | 1299篇 |
2018年 | 23363篇 |
2017年 | 18411篇 |
2016年 | 20998篇 |
2015年 | 3406篇 |
2014年 | 3810篇 |
2013年 | 4195篇 |
2012年 | 12083篇 |
2011年 | 25481篇 |
2010年 | 21355篇 |
2009年 | 13679篇 |
2008年 | 22626篇 |
2007年 | 24499篇 |
2006年 | 3100篇 |
2005年 | 4420篇 |
2004年 | 5302篇 |
2003年 | 5935篇 |
2002年 | 3844篇 |
2001年 | 1613篇 |
2000年 | 1655篇 |
1999年 | 1055篇 |
1998年 | 552篇 |
1997年 | 445篇 |
1996年 | 291篇 |
1995年 | 271篇 |
1994年 | 240篇 |
1993年 | 187篇 |
1992年 | 366篇 |
1991年 | 397篇 |
1990年 | 400篇 |
1989年 | 331篇 |
1988年 | 297篇 |
1987年 | 285篇 |
1986年 | 198篇 |
1985年 | 193篇 |
1984年 | 137篇 |
1983年 | 131篇 |
1982年 | 79篇 |
1981年 | 58篇 |
1980年 | 79篇 |
1979年 | 83篇 |
1978年 | 76篇 |
1974年 | 79篇 |
1970年 | 68篇 |
1938年 | 62篇 |
1932年 | 63篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
121.
Carlos Ferrer Albiach Antonio Conde Moreno Marta Rodríguez Cordón Virginia Morillo Macías Ana Bouché Babiloni Inmaculada Beato Tortajada Ángel Sánchez Iglesias Alicia Francés Muñoz 《Clinical & translational oncology》2010,12(1):22-26
Hypoxia is related to poor prognosis because it is associated to chemo-and radioresistance. During recent years the evolution
of imaging methods like PET/CT and MRI has meant the appearance of new perspectives with direct implications in radiation
therapy. We discuss previous experiences in staging, planning and in the follow-up process with these techniques for measuring
tumour hypoxia. 相似文献
122.
Lidong Zhang James E Littlejohn Yu Cui Xiaobo Cao Chander Peddaboina W Roy Smythe 《Molecular cancer》2010,9(1):110
Background
Bortezomib, a proteasome-specific inhibitor, has emerged as a promising cancer therapeutic agent. However, development of resistance to bortezomib may pose a challenge to effective anticancer therapy. Therefore, characterization of cellular mechanisms involved in bortezomib resistance and development of effective strategies to overcome this resistance represent important steps in the advancement of bortezomib-mediated cancer therapy. 相似文献123.
Background
The fibromyalgia syndrome (FMS) is suggested to be a manifestation of depression or affective spectrum disorder. We measured the cognitive style of patients with FMS to assess personality styles in 44 patients with fibromyalgia syndrome (FMS) by comparing them with 43 patients with major depressive disorder (MDD) and 41 healthy controls (HC). 相似文献124.
125.
126.
Kimberly A. Varker Edward W. Martin Dori Klemanski Bryan Palmer Manisha H. Shah Mark Bloomston 《Journal of gastrointestinal surgery》2007,11(12):1680-1685
Background
Transarterial chemoemobolization (TACE) is commonly used to treat metastatic carcinoid tumors; however, the management of
progressive disease is less clear. We sought to determine if patients with disease progression after TACE would benefit from
repeat TACE.
Methods
The records of 27 patients undergoing repeat TACE for radiologic or symptomatic progression after TACE for metastatic carcinoid
were reviewed and compared to 122 undergoing first TACE. Overall and progression-free survivals were estimated by the Kaplan–Meier
method.
Results
Mean disease-free interval after first TACE was 11.8 months. Radiologic response was observed in 61% compared to 82% after
first TACE (p = 0.058); hormone response in 64% compared to 80% (p = 0.159); and symptomatic response in 77% compared to 92% (p = 0.053). The complication rate after repeat TACE was lower than after first TACE (p = 0.03). Median overall survival was similar after repeat (28.1 months) and first TACE (33.3 months) (p = 0.53). Progression-free survival was shorter after repeat TACE but not significantly so. No factor examined could predict
survival after repeat TACE.
Conclusion
Repeat TACE for patients with hepatic carcinoid metastases failing first TACE or having evidence of disease progression is
safe and offers a viable treatment option.
Presented at the 48th Annual Meeting of The Society for Surgery of the Alimentary Tract, Washington, DC, May, 2007. 相似文献
127.
Cholangiocarcinomas (CC) frequently demonstrate lymphatic spread. We investigated lymph node (LN) counts after resection of
extrahepatic CC and survival based on the SEER 1973–2004 database. Out of 20,068 CC patients, 1,518 individuals were selected
based on M0 stage and at least one LN examined. Primary cancer sites included gallbladder (29%), extrahepatic bile ducts (26%),
and intrapancreatic/ampullary bile ducts (45%); 42% of patients were LN-positive. The median number of LNs examined was four
(range 1–39). Median survival was 37 months for LN-negative and 16 months for LN-positive cancers. Multivariate prognostic
variables were the number of positive LNs, primary site, age (all at p < 0.0001), gender (p = 0.002), size (p = 0.005), T category (p = 0.009), and total LN count (or number of negative LNs obtained, p = 0.01). The impact of total LN counts was seen in LN-negative (median survival, 1 vs 10 or more LNs examined: 27 vs 51 months,
p = 0.002) and LN-positive disease (10 vs 22 months, p < 0.0001). Survival prediction of extrahepatic CCs is strongly influenced by total LN counts and numbers of negative LNs
obtained. Although the resulting incremental benefit is small, dissection and examination of 10 or more LNs should be considered
for curative intent resections. 相似文献
128.
Dong-Youn Lee MD PhD ; Jun-Mo Yang MD PhD ; Kwan-Hyun Park MD PhD 《Wound repair and regeneration》2007,15(6):936-939
We have recently developed a new dermal equivalent without exogenous materials by culturing dermal fibroblasts alone in serum-containing medium treated with several supplements. In this study, we investigated the effects of epidermal growth factor (EGF) and insulin on the formation of a dermal equivalent. After cultured dermal fibroblasts reached a confluence in serum-containing medium, they were treated with EGF or insulin. The combined effects of EGF and insulin were also studied. Macroscopically, in contrast to the culture without supplement, the addition of EGF or insulin produced a fibrous sheet. The combination of EGF and insulin showed a more marked effect than a single factor. Histologically, EGF or insulin alone induced a three-dimensional tissue containing several layers of fibroblasts. The combination of EGF and insulin produced a thicker tissue. It was composed of abundant extracellular matrix containing fibroblasts, suggesting a dermis-like tissue. It revealed collagen fibers by Masson-trichrome staining. Immunohistochemically, the components of dermal extracellular matrix such as type 1 collagen, elastin, and fibrillin-1 were diffusely expressed. Ultrastructurally, a large number of collagen fibrils with cross-striated patterns were found around the fibroblasts. These results showed that a dermal equivalent could be formed by culturing dermal fibroblasts alone postconfluently in serum-containing medium with EGF and insulin. They suggest that the two factors play an important role in the formation of a dermal equivalent. 相似文献
129.
130.
Introduction Choroid plexus cysts can lead to isolation of the lateral ventricles and distension of the third ventricle. We present an
ultrasonographic video documentation of an infant with variably shaped and localized choroid plexus cyst of the third ventricle.
Case report An infant had periods of increased intracranial pressure with changing dilatation of the first to third ventricle. Cerebral
ultrasonography of the not crying boy demonstrated a choroid plexus cyst limply hanging down from the roof of the third ventricle
to the beginning of the aqueduct of Sylvius. During crying, the cyst prolapsed from the third into left lateral ventricle
and was strangled by the foramen of Monro. Endoscopic cyst fenestration and third ventriculostomy continuously solved the
problem of intermittent hydrocephalus occlusus.
Conclusion Depending not only on localization and size but also on cyst form and cerebrospinal fluid pressure, a single choroid plexus
cyst can cause various obstructions of cerebrospinal fluid pathways. 相似文献