利用贝朗Diapact CRRT实现双重血浆置换新功能的研究

本文介绍了以贝朗Diapact CRRT原有治疗模式为基础．结合该机只用一个称重系统保持液体平衡的设计特点，实现双重血浆置换新功能的原理、方法和临床应用。     

Survivin和bFGF在胃癌及肠化生组织中的表达及其与胃癌血管生成的关系

目的探讨Survivin和bFGF在胃癌及肠化生组织中的表达及其与胃癌血管生成的关系,为胃癌的诊断、治疗及预后判断提供依据。方法应用免疫组化S-P法检测44例胃癌组织、22例肠化生组织和10例正常胃黏膜组织中的Survivin、bFGF的表达和MVD值,分析Survivin、bFGF表达、MVD值与临床病理因素间的关系。结果在44例胃癌组织、22例肠化生组织和10例正常胃黏膜组织中Survivin、bFGF和MVD3种标记物在3组组织之间差异有统计学意义(P<0.05)。在胃癌组织中Survivin、bFGF表达及MVD值均与肿瘤浸润深度、淋巴结转移、TNM分期有关(P<0.05)。胃癌组织中Survivin和bF-GF表达与MVD值均有相关性(P<0.05)。胃癌组织中Survivin和bFGF两者均阳性组中MVD值与两者均阴性组相比差异有统计学意义(P<0.05)。结论胃癌组中Survivin、bFGF的表达均与MVD值有明显相关性,bFGF和Survivin的表达共同促进胃癌血管的生成。联合检测Survivin、bFGF和MVD有助于对胃癌的病理分级、恶性程度判定和预后判断。     

Child abuse by burning--an index of suspicion

Although general awareness of child abuse is increasing, abuse by burning is often unrecognized. Seventy-one consecutive children admitted with inflicted burns were studied. Mean age was 1.8 yrs and mean burn size was 13.5%. Mean length of stay was 18.9 days. Scalds (83% from tap water) were the most frequent cause of injury. An immersion pattern was present in 59%; six patients had a classic forced immersion injury. Fourteen children had nonburn trauma. Four patients died: all had tap water immersion burns. Inflicted burns are usually manifested by characteristic patterns of injury, which must be correlated with the given history. When compared with accidentally burned children, abused children were significantly younger, had longer hospital stays, and had a higher mortality. A team approach to child abuse with the addition of a specially trained group is important to insure prompt recognition, more objective appraisals, and further followup.     

Reward summation and the effects of pimozide, clonidine, and amphetamine on fixed-interval responding for brain stimulation.

Two models of reward summation were examined in 16 rats lever pressing for intracranial stimulation under fixed-interval (FI) reinforcement. The first model examined rate-frequency functions and the second model traded off frequency and train duration. The second model was selected to assess the effects of three drugs on reward summation. Both clonidine and pimozide inhibited FI self-stimulation, but pimozide's effect could not be distinguished from a performance deficit. Two amphetamine isomers facilitated self-stimulation in a manner suggesting enhanced reinforcement. The dextro isomer was four times more effective than the levo isomer to facilitate self-stimulation. This study shows that the combination of the FI schedule with a reward-summation model is well suited for evaluating the effects of drugs on self-stimulation. The advantages of this model are that inter-reinforcement intervals are separated, which minimizes priming and stimulation aftereffects, and more responding does not increase stimulation availability, thus eliminating rate-dependency effects.     

Flavin analogs with antimalarial activity as glutathione reductase inhibitors

10-(4'-Chlorophenyl)-3-methylflavin has antimalarial activity in vitro and in vivo (Cowden et al., J Med Chem 31: 799, 1988). This flavin analog and two of its derivatives were found to inhibit the antioxidant flavoenzyme glutathione reductase from human erythrocytes in its isolated form as well as in hemolysates. The mixed-type inhibition was completely reversible, the Ki-values being of the order of 1 microM. Surprisingly, the drugs were not competitive with FAD, but with GSSG, one of the enzyme's substrates. Malaria parasite glutathione reductase, extracted from Plasmodium falciparum, could also be inhibited by the compounds. Studies on the effects of the substances on P. falciparum in vitro, which were demonstrated morphologically and by growth inhibition, confirmed previous observations with 10-(4'-chlorophenyl)-3-methylflavin and showed similar parasiticidal characteristics for the two new derivatives. The activities of five other erythrocytic enzymes tested were not impaired by the drugs, nor was the nucleotide metabolism of erythrocytes and/or parasites significantly changed. Permeation into red blood cells was demonstrated for one compound by 19F-NMR-spectroscopy. Inhibition of glutathione reductase might contribute to, or account for, the antimalarial activity of this group of flavin analogs.     

开展电话回访搭建医患沟通桥梁

通过对3 500余人次的有效电话回访,实施健康教育、健康指导3000余人次,受理健康咨询500余人次,协调和化解各类医疗纠纷20余起。电话回访搭起了和谐医患关系的桥梁。     

Percent agreement, Pearson's correlation, and kappa as measures of inter-examiner reliability

Percent agreement and Pearson's correlation coefficient are frequently used to represent inter-examiner reliability, but these measures can be misleading. The use of percent agreement to measure inter-examiner agreement should be discouraged, because it does not take into account the agreement due solely to chance. Caution must be used in the interpretation of Pearson's correlation, because it is unaffected by the presence of any systematic biases. Analyses of data from a reliability study show that even though percent agreement and kappa were consistently high among three examiners, the reliability measured by Pearson's correlation was inconsistent. This study shows that correlation and kappa can be used together to uncover non-random examiner error.     

复方金银花擦剂中没食子酸的含量测定

目的：建立测定复方金银花擦剂中没食子酸的含量测定方法。方法：Novapak C18色谱柱，流动相甲醇冰醋酸-二甲基酰胺-水（2：0．5：20：90），检测波长275nm。结果：该法线性关系良好，相关系数r=0．9996，加样回收率为99．02％，RSD=1．94％。结论：该方法操作简单，分离效果好，可用于复方金银花擦剂的质量控制。     

侧脑室注射东莨菪碱和酚妥拉明对幼兔分辨学习的影响

目的 探讨东莨菪碱和酚妥拉明对幼兔分辨学习的影响。方法 将30只比利时纯种幼兔从生后13日龄随机分为三组：东莨菪碱组、酚妥拉明组和生理盐水对照组，观察不同日龄各组幼兔的分辨学习能力。结果 幼兔分辨学习的正确反应一般始于生后15日龄。侧脑室注射东莨菪碱对16日龄以前幼兔分辨学习无明显影响，对17日龄以后幼兔分辨学习产生明显抑制作用。侧脑室注射酚妥拉明对13—23日龄幼兔分辨学习均有明显抑制作用。结论 幼兔生后发育过程中学习能力的发展具明显的阶段性，其原因可能与神经递质系统的发育成熟有关。     

用科学理论指导"五四一"医院经营管理模式的研究

本文介绍了广东省第二人民医院,用科学理论指导"五四一"医院经营管理模式研究的改革实践.分别阐述了"五四一"医院经营管理模式的研究基础、方向和核心目标.