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排序方式: 共有121条查询结果,搜索用时 46 毫秒
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Hyperostosis may affect prognosis after primary endoscopic sinus surgery for chronic rhinosinusitis.
Hyo Yeol Kim Hun-Jong Dhong Hyun Jong Lee Young-Jun Chung Yoo Jeong Yim Jae-Won Oh Seung-Kyu Chung Hyung Jin Kim 《Otolaryngology--head and neck surgery》2006,135(1):94-99
OBJECTIVE: To investigate the independent effect of hyperostosis on outcome after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS). STUDY DESIGN AND SETTING: The medical records of 81 consecutive patients who had undergone primary ESS for CRS were reviewed retrospectively. Sinus CT scans were evaluated for the presence of hyperostosis to investigate the association with postoperative outcomes. The independent effect of hyperostosis on surgical outcome was analyzed, controlling for possible confounding factors with a multiple logistic regression model. RESULTS: Sixty percent of the patients showed hyperostosis, and there was a statistically significant association between the hyperostosis and postoperative outcome (P = 0.035, chi(2) test), which was confirmed after adjustment for the possible confounding factors (P = 0.048, odds ratio [OR] = 3.19, logistic regression analysis). CONCLUSIONS: Our study suggests that patients with CRS who have hyperostosis may have a poorer surgical outcome than those without hyperostosis. EBM rating: B-2b. 相似文献
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Background
This study aimed to evaluate the clinical outcomes of arthroscopic decortication of the inferior patellar pole in athletes with refractory chronic patellar tendinopathy.Methods
Thirty-seven athletes in whom conservative management for at least six months failed underwent arthroscopic patellar tendon debridement and decortication of the inferior pole of the patella. Clinical outcomes were evaluated using subjective knee scores and isokinetic muscle strength tests. The average duration taken and sports participation level were also assessed.Results
The mean follow-up period was 51.3 ± 14.8 months. At the last follow-up, all improvements in subjective knee scores including Lysholm score, International Knee Documentation Committee (IKDC) subjective score, Victorian Institute of Sport Assessment -Patella (VISA-P) score, and Kujala score were statistically significant (p < .001). Tegner activity scale improved from 6.5 ± 1.0 to 8.9 ± 0.8 (p < .001). Limb symmetry index for extensor peak torque improved from 71.4 ± 19.6% to 92.7 ± 21.7% (p < .001). Thirty-two (86.5 %) athletes were able to return to full sports activities in a mean 3.5 ± 1.7 months, and 27 (73%) athletes maintained their previous sports activity level at the last follow-up. Symptoms recurred in two (5.2%).Conclusions
Arthroscopic decortication of the inferior pole of the patella showed satisfactory clinical results and high rates of return to sports at mid-term follow-up in professional athletes with refractory chronic patellar tendinopathy. This technique could be an invasive, safe, and effective treatment for chronic patellar tendinopathy in professional athletes who want a faster return to sports.Level of evidence
Level IV, case series. 相似文献45.
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Dhong Won Lee Suk Hwan Jang Jeong Ku Ha Jin Goo Kim Jin Hwan Ahn 《Knee surgery, sports traumatology, arthroscopy》2013,21(3):654-657
A complete posterior medial meniscus root tear results in the inability to withstand hoop stress and requires the repair of the posterior medial meniscus root. Several techniques to repair the posterior medial meniscus root have been proposed, but most techniques are based on simple stitching. A modified Mason–Allen technique, recognized as a superior stitching method to repair rotator cuff in shoulder surgery, was applied to overcome the potential weakness of those simple stitching techniques. This newly modified Mason–Allen technique reproduces the locking effect of a conventional modified Mason–Allen stitch allowing the physiological meniscal extrusion. The purpose of this article is to describe a posterior root repair technique using a modified Mason–Allen stitch with two strands consisting of a simple horizontal and a simple vertical stitch. Level of evidence V. 相似文献
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Ahmed Aribi Sigal Gery Dhong Hyun Lee Nils H. Thoennissen Gabriela B. Thoennissen Rocio Alvarez Quoc Ho Kunik Lee Ngan B. Doan Kin T. Chan Melvin Toh Jonathan W. Said H. Phillip Koeffler 《International journal of cancer. Journal international du cancer》2013,132(12):2730-2737
Despite recent advances in therapy, breast cancer remains the second most common cause of death from malignancy in women. Chemotherapy plays a major role in breast cancer management, and combining chemotherapeutic agents with nonchemotherapeutic agents is of considerable clinical interest. Cucurbitacins are triterpenes compounds found in plants of the Cucurbitaceae family, reported to have anticancer and anti‐inflammatory activities. Previously, we have shown antiproliferative activity of cucurbitacin B (CuB) in breast cancer, and we hypothesized that combining CuB with chemotherapeutic agents can augment their antitumor effect. Here, we show that a combination of CuB with either docetaxel (DOC) or gemcitabine (GEM) synergistically inhibited the proliferation of MDA‐MB‐231 breast cancer cells in vitro. This antiproliferative effect was accompanied by an increase in apoptosis rates. Furthermore, in vivo treatment of human breast cancer orthotopic xenografts in immunodeficient mice with CuB at either low (0.5 mg/kg) or high (1 mg/kg) doses in combination with either DOC (20 mg/kg) or GEM (12.5mg/kg) significantly reduced tumor volume as compared with monotherapy of each drug. Importantly, no significant toxicity was noted with low‐dose CuB in combination with either DOC or GEM. In conclusion, combination of CuB at a relatively low concentration with either of the chemotherapeutic agents, DOC or GEM, shows prominent antiproliferative activity against breast cancer cells without increased toxicity. This promising combination should be examined in therapeutic trials of breast cancer. 相似文献
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Yoo Seob Shin MD PhD Jung‐Won Park MD PhD Yong‐Won Lee MD MS Cheol‐Woo Kim MD PhD Hun‐Jong Dhong MD PhD Hae‐Sim Park MD PhD Young‐Joo Cho MD PhD Sang‐Heon Cho MD PhD Bok Yang Pyun MD PhD Kwang Hoon. Lee MD PhD Hae Ran Lee MD PhD Chein‐Soo Hong MD PhD 《Pharmacoepidemiology and drug safety》2011,20(1):99-104
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Min Hur Sun-Kyung Park Chang-Hoon Koo Eun Dhong Jung Pyoyoon Kang 《Acta orthopaedica》2017,88(6):634-641
Background and purpose — New oral anticoagulants have been developed to prevent venous thromboembolism (VTE) after knee or hip arthroplasty. Although there have been several network meta-analyses (NMA) to compare different regimens, an NMA including 2 different enoxaparin doses and edoxaban has not been performed.Methods — Standard NMA for fondaparinux, dabigatran, rivaroxaban, apixaban, edoxaban, and enoxaparin was performed. Outcome variables included a composite of total VTE and major/clinically relevant bleeding. The rank probabilities of each treatment outcome were summarized by the surface under the cumulative ranking curve.Results — Fondaparinux, rivaroxaban, and apixaban were associated with a reduced risk of VTE compared with enoxaparin, while dabigatran was not. None of these 3 drugs increased bleeding compared with enoxaparin 30?mg twice daily. However, fondaparinux and rivaroxaban increased bleeding compared with enoxaparin 40?mg once daily, while apixaban did not. Apixaban was even associated with decreased major/clinically relevant bleeding compared with enoxaparin 30?mg twice daily or 40?mg once daily. When edoxaban was included in the NMA, edoxaban decreased VTE and did not increase bleeding compared with enoxaparin.Interpretation — A higher efficacy of fondaparinux and rivaroxaban compared with enoxaparin was associated with increased bleeding tendency, while apixaban was superior to enoxaparin regarding both efficacy and safety. A clustered ranking plot showed that apixaban might be the most preferred regarding efficacy and safety. However, our results were driven by indirect statistical inference and were limited by the heterogeneity of the bleeding outcome definitions, drug initiation and continuation, and different surgery types. 相似文献