全文获取类型
收费全文 | 1326篇 |
免费 | 75篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 71篇 |
妇产科学 | 30篇 |
基础医学 | 155篇 |
口腔科学 | 45篇 |
临床医学 | 102篇 |
内科学 | 291篇 |
皮肤病学 | 24篇 |
神经病学 | 36篇 |
特种医学 | 419篇 |
外科学 | 85篇 |
综合类 | 39篇 |
预防医学 | 23篇 |
眼科学 | 7篇 |
药学 | 39篇 |
1篇 | |
肿瘤学 | 30篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 9篇 |
2017年 | 14篇 |
2016年 | 10篇 |
2015年 | 13篇 |
2014年 | 30篇 |
2013年 | 33篇 |
2012年 | 15篇 |
2011年 | 21篇 |
2010年 | 34篇 |
2009年 | 52篇 |
2008年 | 22篇 |
2007年 | 36篇 |
2006年 | 27篇 |
2005年 | 23篇 |
2004年 | 17篇 |
2003年 | 17篇 |
2002年 | 10篇 |
2001年 | 18篇 |
2000年 | 9篇 |
1999年 | 18篇 |
1998年 | 78篇 |
1997年 | 79篇 |
1996年 | 79篇 |
1995年 | 64篇 |
1994年 | 39篇 |
1993年 | 58篇 |
1992年 | 7篇 |
1991年 | 11篇 |
1990年 | 24篇 |
1989年 | 54篇 |
1988年 | 42篇 |
1987年 | 46篇 |
1986年 | 52篇 |
1985年 | 67篇 |
1984年 | 35篇 |
1983年 | 29篇 |
1982年 | 28篇 |
1981年 | 32篇 |
1980年 | 38篇 |
1979年 | 5篇 |
1978年 | 19篇 |
1977年 | 23篇 |
1976年 | 21篇 |
1975年 | 21篇 |
1914年 | 1篇 |
排序方式: 共有1405条查询结果,搜索用时 46 毫秒
991.
992.
WE Bloembergen RM Hakim DC Stannard PJ Held RA Wolfe LY Agodoa FK Port 《American journal of kidney diseases》1999,33(1):1-10
A number of studies have suggested that type of dialysis membrane is associated with differences in long-term outcome of patients undergoing hemodialysis, both in terms of morbidity and mortality. The purpose of this study was to determine the relationship of membrane type and specific causes of death. Data from the United States Renal Data System Case Mix Adequacy Study, a national random sample of hemodialysis patients who were alive on December 31, 1990, were used. Our study was limited to patients in this data set who were undergoing dialysis for at least 1 year (n = 4,055). For the main analytic models, membrane type was classified into two categories: unmodified cellulose or MC/SYN (which combines modified cellulose [MC] and synthetic membranes [SYN]). The relationships of membrane type and major causes of mortality were analyzed using Cox proportional hazards models, which adjusted for multiple (21) covariates, including demographics, comorbidity, Kt/V, and other parameters. Patients were censored at transplantation or 60 days after a switch to peritoneal dialysis. Compared with patients dialyzed with unmodified cellulose membranes, the adjusted relative mortality risk (RR) from infection was 31% lower (RR = 0.69; P = 0.03) and from coronary artery disease was 26% lower (RR = 0.74; P = 0.07) for patients dialyzed with MC/SYN membranes. No statistically significant difference (all P > 0.1) was found in mortality risk from cerebrovascular disease (RR = 1.08), other cardiac causes (RR = 0.86), malignancy (RR = 0.90), or other known causes (RR = 0.82) between patients dialyzed with MC/SYN compared with unmodified cellulose membranes. These results offer support to reported experimental and observational clinical studies that have found that unmodified cellulose membranes may increase the risk for both infection and atherogenesis. Further studies are necessary to evaluate the possibility of confounding factors, compare more specific membrane types, and determine the pathophysiology linking membrane type to cause-specific mortality. 相似文献
993.
RA Kapur PA McCann PP Sarangi 《Annals of the Royal College of Surgeons of England》2014,96(7):e32-e35
The management of skeletal metastases can be challenging for the orthopaedic surgeon. They represent a significant source of pain and disability for cancer patients, adding to the morbidity of their condition. Treatment is directed at the alleviation of symptoms and the restoration of function. Metastatic involvement of the proximal humerus can be especially debilitating, having the potential to cause severe pain and loss of function. We present a report of three such cases where reverse geometry proximal shoulder replacement was used to provide a pain free functional range of movement in patients with concomitant rotator cuff disease. In all cases, significant symptomatic relief was achieved postoperatively with preservation of upper limb function. No surgical complications were noted. It is our belief that this novel surgical strategy provides a valuable and effective option for the management of proximal humeral metastatic disease in the rotator cuff deficient patient. 相似文献
994.
995.
996.
997.
998.
Therapeutic angiogenesis constitutes an alternative treatment for patients with extensive tissue ischaemia in whom primary vascular reconstruction procedures are not feasible or have previously failed. At present vascular endothelial growth factor (VEGF) has been the most widely used angiogenic factor in experimental and human clinical trials. Early clinical data provide evidence that gene transfer of the VEGF gene can achieve beneficial angiogenesis, with minimal side-effects. Ongoing phase III clinical studies will reveal definitive efficacy. 相似文献
999.
1000.
S Pamujula V Kishore B Rider CD Fermin RA Graves KC Agrawal 《International journal of radiation biology》2013,89(3):251-257
Purpose: Amifostine (Ethyol®) is an approved cytoprotective agent prescribed to reduce certain side-effects in the chemotherapy of ovarian or non-small cell lung cancer, or in radiation treatment of head-and-neck cancer. The usefulness of this drug is further hampered, because it is not effective when given orally. The objective of this part of the project was to evaluate the radioprotective efficacy of orally active amifostine nanoparticles.Materials and methods: Radioprotective efficacy was evaluated by measuring the ability of the amifostine nanoparticles (equivalent to 500?mg/Kg) to inhibit whole-body gamma irradiation -induced injury in mice. All mice received acute whole-body gamma irradiation from a Cesium-137 source and the radioprotective efficacy of the formulation was determined by measuring 30-day survival at 9?Gy, bone marrow hemopoeitic progenitor cell survival at 9?Gy and 8?Gy, and intestinal crypt cell survival at 11?Gy.Results: Thirty-day survival, hemopoietic progenitor cell survival, as well as the jejunal crypt cell survival were all significantly enhanced when the mice were treated orally with the amifostine nanoparticles 1?h prior to irradiation.Conclusions: These results clearly and unequivocally demonstrate that the amifostine nanoparticles developed in our laboratory provides significant protection from acute whole-body gamma irradiation injury in mice. 相似文献