Heterotopic salivary gland presenting as a supra-clavicular swelling

A 5-month-old female was referred to the paediatric surgery clinic with a neck swelling in the right supra-clavicular region. This was thought clinically to be cystic hygroma. Pathology showed an ectopic salivary gland. This should be added to the list of differential diagnoses of neck swelling in childhood.     

Modified synthesis of 11-[C]-clozapine

The reported synthetic pathway of 8-chloro-11-(4-methyl-1-piperazinyl)-11-[¹⁴C]-5H-dibenzo[b,e][1,4]diazapine (clozapine) was modified in several steps. The synthetic pathway was shortened by 60% and the total yield was increased from 6% to 23%.     

Psychometric properties of the Iranian version of the Sexual Modes Questionnaire (SMQ): to assess the association between automatic thoughts,emotions and sexual response

The role of cognitive-affective factors on male and female sexual functioning has been studied in North America and European countries and there is a lack of validated measures available for use elsewhere. The aim of this study was to translate and validate the Sexual Modes Questionnaire (SMQ) to the Iranian context. The SMQ is a validated measure aimed at assessing the association between thoughts, emotions and sexual response during sexual activity. A total of 388 participants (224 women and 164 men) completed the SMQ. A principal component analysis with varimax rotation and subsequent confirmatory factor analysis (CFA) were performed. Three factors were identified in the male version: Failure Anticipation Thoughts, Erection Concern Thoughts, and Lack of Erotic Thoughts. In the female version, six factors were identified: Failure and Disengagement Thoughts, Low Self-Body Image Thoughts, Sexual Abuse Thoughts, Sexual Passivity and Control, Lack of Erotic Thoughts, and Partner's Lack of Affection. Also, a consistent pattern of correlations was found between the three subscales of the SMQ (thoughts, emotions, and sexual response) supporting the interactional character of the measure. This study has provided some preliminary evidence of the reliability and validity of the SMQ for use in Iranian populations.     

Computational study for temperature distribution in ArF excimer laser corneal refractive surgeries using different beam delivery techniques

Lasers in Medical Science - Refractive errors are the most common causes of vision impairment worldwide and laser refractive surgery is one of the most frequently performed ocular surgeries....     

Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro

OBJECTIVE: Vascular calcification is an actively regulated process, correlating with cardiovascular morbidity and mortality especially in patients with diabetes and chronic renal diseases. Osteopontin (OPN) is abundantly expressed in human calcified arteries and inhibits vascular calcification in vitro and in vivo. How OPN functions in vascular calcification, however, is less clear. METHODS: Smooth muscle cells (SMCs) were isolated from aortas of OPN knock-out (OPN-/-) and wild type (OPN+/+) mice. RESULTS: OPN-/- SMCs were identical to OPN+/+ SMCs in morphology and stained positively for SM lineage proteins, desmin, smooth muscle alpha-actin and SM22alpha. No spontaneous calcification was observed in OPN-/- SMCs under normal culture conditions or in medium containing 1%, 3%, or 5% fetal bovine serum. However, when cultured in medium containing elevated concentrations of inorganic phosphate, an inducer of vascular calcification, a significantly higher calcification was observed in OPN-/- SMCs compared to OPN+/+ SMCs that, in response to elevated phosphate, synthesized and secreted OPN into the culture. Finally, retroviral transduction of mouse OPN cDNA into OPN-/- SMCs rescued the calcification phenotype of the cells. CONCLUSION: These results are the first to demonstrate an inhibitory role of endogenously produced OPN on SMC calcification, suggesting a novel feedback mechanism where OPN produced locally by the SMCs may serve as an important inducible inhibitor of vascular calcification.