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81.
Andre C. Felicio Tais S. Moriyama Clecio Godeiro-Junior Ming C. Shih Marcelo Q. Hoexter Vanderci Borges Sonia M. A. Silva Edson Amaro-Junior Luiz A. F. Andrade Henrique B. Ferraz Rodrigo A. Bressan 《Psychopharmacology》2010,211(1):27-31
Rationale
Depression is a frequent non-motor symptom in Parkinson’s disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is not clear since clinical matching was inappropriate and DAT reduction could be attributed to PD severity.Objectives
To further examine the role of DAT in PD depression, this study compared thoroughly matched depressed vs. non-depressed PD patients (ndPD).Materials and methods
Twenty PD patients (n?=?10 ndPD; n?=?10 dPD) matched for age and disease severity were submitted to brain SPECT imaging with [99mTc]-TRODAT-1, a DAT radioligand. DAT-binding potential was calculated using regions of interest bilaterally drawn in the striatum, caudate, and putamen. Depression was defined according to Beck Depression Inventory (BDI; cut-off >18).Results
Mean BDI scores were higher in dPD (25.0?±?5.6) than in ndPD patients (8.0?±?1.9, p?<?0.0001). DAT density was greater on dPD especially in the left caudate (dPD 0.87?±?0.19 vs. ndDP 0.69?±?0.18, p?=?0.02) and right putamen (dPD 0.37?±?0.07 vs. ndPD 0.28?±?0.13, p?=?0.03) than in ndPD patients.Conclusion
Our results suggest that in vivo DAT density is increased in dPD patients as compared to ndPD, suggesting that DAT is implicated in the pathophysiology of PD depression. 相似文献82.
Dr. Barton Hoexter M.D. Samuel B. Labow M.D. Michael D. Moseson M.D. 《Diseases of the colon and rectum》1985,28(8):572-575
In this update, 15 additional successful transanal repairs followed for one to six years postoperatively for low rectovaginal
fistulas without colostomies are added to the uniformly successful 20 patients presented in a 1978 report. Changes in perioperative
routines have greatly enhanced cost efficiency and these modifications are enumerated. The repair still encompasses total
excision of the epithelialized fistula, and reapproximation of the attenuated septal fibers and anal sphincter mechanism,
as well as the caudad rectal mucosal advancement that covers and protects the repair from the fecal stream and the high intraluminal
pressures of defecation. Once again, we have excluded inflammatory, neoplastic, and irradiation-caused fistulas from this
discussion, although we, as well as others, have applied this technique in selected cases. 相似文献
83.
Dr. Samuel B. Labow M.D. Barton Hoexter M.D. Myron Susin M.D. 《Diseases of the colon and rectum》1977,20(7):606-607
Summary A benign presacral tumor composed of adipose and hematopoietic tissue was found in an asymptomatic 47-year-old woman. Due
to the patient's associated medical conditions the tumor was diagnosed by transanal biopsy and was not removed. Only three
similar cases have been reported. 相似文献
84.
D L Hoexter 《Journal of periodontology》1979,50(2):75-78
A technique designed to utilize the autogenous free gingival graft without the use of sutures was demonstrated. Necessary objectives were maintained but achieved without unnecessarily piercing the graft, and in less time. The only variance in results would be due to the underlying physical properties of the recipient site. This new approach to grafting avoids the cyanoacrylate from getting between the graft and recipient site, therefore acting as a foreign body. Also shown was the complete coverage of a denuded root surface by this technique using a free autogenous gingival graft. This technique enables the surgeon to achieve the results of a predictable technique (autogenous free gingival graft) even more predictably simple. 相似文献
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90.
Ming Chi Shih Luiz Augusto Franco de Andrade Edson Amaro Andre Carvalho Felicio Henrique Ballalai Ferraz Jairo Wagner Marcelo Queiroz Hoexter Li Fu Lin Ying Kai Fu Jair Jesus Mari Sergio Tufik Rodrigo Affonseca Bressan 《Movement disorders》2007,22(6):863-866
Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening. 相似文献