全文获取类型
收费全文 | 2651篇 |
免费 | 157篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 188篇 |
妇产科学 | 29篇 |
基础医学 | 304篇 |
口腔科学 | 66篇 |
临床医学 | 310篇 |
内科学 | 594篇 |
皮肤病学 | 81篇 |
神经病学 | 132篇 |
特种医学 | 402篇 |
外科学 | 187篇 |
综合类 | 59篇 |
预防医学 | 197篇 |
眼科学 | 37篇 |
药学 | 133篇 |
2篇 | |
肿瘤学 | 151篇 |
出版年
2022年 | 16篇 |
2021年 | 18篇 |
2020年 | 25篇 |
2019年 | 20篇 |
2018年 | 47篇 |
2017年 | 26篇 |
2016年 | 28篇 |
2015年 | 49篇 |
2014年 | 66篇 |
2013年 | 80篇 |
2012年 | 64篇 |
2011年 | 68篇 |
2010年 | 110篇 |
2009年 | 99篇 |
2008年 | 77篇 |
2007年 | 122篇 |
2006年 | 82篇 |
2005年 | 87篇 |
2004年 | 54篇 |
2003年 | 43篇 |
2002年 | 49篇 |
2001年 | 59篇 |
2000年 | 57篇 |
1999年 | 49篇 |
1998年 | 133篇 |
1997年 | 157篇 |
1996年 | 139篇 |
1995年 | 111篇 |
1994年 | 117篇 |
1993年 | 102篇 |
1992年 | 47篇 |
1991年 | 48篇 |
1990年 | 48篇 |
1989年 | 67篇 |
1988年 | 58篇 |
1987年 | 53篇 |
1986年 | 60篇 |
1985年 | 53篇 |
1984年 | 32篇 |
1983年 | 17篇 |
1982年 | 27篇 |
1981年 | 33篇 |
1980年 | 29篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 21篇 |
1976年 | 29篇 |
1975年 | 17篇 |
1974年 | 13篇 |
1972年 | 8篇 |
排序方式: 共有2884条查询结果,搜索用时 0 毫秒
31.
D Hassine G Rougereau JM Feron MC Henry-Feugeas V Fabre JC Sadik E Schouman-Claeys 《Surgical and radiologic anatomy : SRA》1994,16(3):293-301
Summary The angular points are the ligamentous and tendinous structures that reinforce the posteromedial and posterolateral capsule of the knee and share in fixation of the posterior horns of the menisci. They are often damaged in acute injuries and this is usually associated with ruptures of the cruciate and collateral ligaments and may add to the degree of laxity. We describe the normal appearance of these structures in terms of the sectional anatomy, correlated with the lesional appearances of complete and incomplete ruptures and associated meniscal detachments as shown by clinical testing and arthrotomy findings.
IRM des points d'angle du genou : bases anatomiques et applications aux genoux traumatiques
Résumé Les points d'angle sont des structures ligamentaires et tendineuses qui renforcent la capsule postéro-médiale et postéro-latérale et participent à la fixation des cornes postérieures des ménisques. Leurs lésions, fréquentes au cours des traumatismes aigus, sont généralement associées à des ruptures des ligaments croisés et des ligaments collatéraux et peuvent être source d'une aggravation de la laxité. Nous rapportons, en corrélation avec l'anatomie en coupe, l'aspect normal de ces structures, et en corrélation avec les données de l'arthrotomie et du testing les aspects lésionnels observés au cours des traumatismes : ruptures complètes, incomplètes et désinsertions méniscales associées.相似文献
32.
Stein TP; Oram-Smith JC; Leskiw MJ; Wallace HW; Long LC; Leonard JM 《The American journal of physiology》1976,230(5):1321-1325
33.
34.
Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases 总被引:5,自引:2,他引:5
Huang JQ; Trasler JM; Igdoura S; Michaud J; Hanal N; Gravel RA 《Human molecular genetics》1997,6(11):1879-1885
Tay-Sachs and Sandhoff diseases are autosomal recessive neurodegenerative
diseases resulting from the inability to catabolize GM2 ganglioside by
beta-hexosaminidase A (Hex A) due to mutations of the alpha subunit
(Tay-Sachs disease) or beta subunit (Sandhoff disease) of Hex A. Hex B
(beta beta homodimer) is also defective in Sandhoff disease. We previously
developed mouse models of both diseases and showed that Hexa-/- (Tay-Sachs)
mice remain asymptomatic to at least 1 year of age while Hexb-/- (Sandhoff)
mice succumb to a profound neurodegenerative disease by 4-6 months of age.
Here we find that neuron death in Hexb-/- mice is associated with apoptosis
occurring throughout the CNS, while Hexa-/- mice were minimally involved at
the same age. Studies of autopsy samples of brain and spinal cord from
human Tay-Sachs and Sandhoff diseases revealed apoptosis in both instances,
in keeping with the severe expression of both diseases. We suggest that
neuron death is caused by unscheduled apoptosis, implicating accumulated
GM2 ganglioside or a derivative in triggering of the apoptotic cascade.
相似文献
35.
JM Hopkin 《Current opinion in immunology》1997,9(6):788-792
Atopy — a T helper 2 cell driven hypersensitivity to innocuous antigens (allergens) which causes most cases of asthma — is of complex genetic and environmental origins. There is compelling epidemiological evidence for a rise in atopic disease in ‘westernised’ communities. The changing pattern of microbial exposure in early childhood is suggested to be the principal candidate mechanism for this rise. 相似文献
36.
37.
38.
DL?MagerEmail author AD?Haffajee PM?Devlin CM?Norris MR?Posner JM?Goodson 《Journal of translational medicine》2005,3(1):27
Background
The purpose of the present investigation was to determine if the salivary counts of 40 common oral bacteria in subjects with an oral squamous cell carcinoma (OSCC) lesion would differ from those found in cancer-free (OSCC-free) controls. 相似文献39.
Koukoulis G Ke Y Henley JD Cummings OW 《Archives of pathology & laboratory medicine》2001,125(10):1331-1334
CONTEXT: The pathology of small bowel obstruction in Crohn disease has not been studied extensively. Stricture formation has been attributed mainly to fibrosis, although muscularization of the submucosa has been discussed previously. OBJECTIVE: To identify additional pathologic changes in Crohn disease that could be involved in the formation of strictures. DESIGN: We reviewed 50 ileal resections from patients with Crohn disease. The histopathologic slides were reviewed initially without knowledge of the macroscopic or clinical findings. We identified an unusual muscular proliferation that we refer to as obliterative muscularization of the submucosa, defined as a thick and continuous muscle layer from the mucosal base to the muscularis propria that is at least 1 cm in length. Subsequently, histopathologic findings were correlated with macroscopic and clinical findings. RESULTS: Obliterative muscularization of the submucosa was present in 14 specimens, and in 11 of these 14 it was topographically restricted to strictures. Submucosal fibrosis was observed in sections from adjacent regions. Obliterative muscularization of the submucosa, including thick-walled vessels and hyperplastic nerves but not prominent scarring, was more common in specimens with strictures; the difference was statistically significant (P <.001). CONCLUSIONS: Obliterative muscularization of the submucosa may be pathogenetically involved in the formation of strictures either directly by causing a sustained spasm, or indirectly by minimizing the vasoprotective role of the submucosa, impairing repair and enhancing scarring. 相似文献
40.