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排序方式: 共有4489条查询结果,搜索用时 15 毫秒
71.
Erika Assarsson Jason A. Greenbaum Magnus Sundstr?m Lana Schaffer Jennifer A. Hammond Valerie Pasquetto Carla Oseroff R. Curtis Hendrickson Elliot J. Lefkowitz David C. Tscharke John Sidney Howard Grey Steven R. Head Bjoern Peters Alessandro Sette 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(40):E63-E64
72.
R J Whitley J W Gnann D Hinthorn C Liu R B Pollard F Hayden G J Mertz M Oxman S J Soong 《The Journal of infectious diseases》1992,165(3):450-455
Seventy-three immunocompromised patients with disseminated herpes zoster were evaluated in a double-blind controlled trial of acyclovir (n = 37) versus vidarabine (n = 36) therapy. Acyclovir was administered at 30 mg/kg/day at 8-h intervals and vidarabine was given as a continuous 12-h infusion at 10 mg/kg/day for 7 days (longer if resolution of cutaneous or visceral disease was incomplete). No demographic differences existed between treatment groups. No deaths attributable to varicella-zoster virus infection occurred within 1 month of treatment. Neither rates of cutaneous healing, resolution of acute neuritis, and frequency of postherpetic neuralgia nor adverse clinical and laboratory events differed between treatment groups. Acyclovir recipients were discharged from the hospital more promptly than vidarabine recipients (P = .04, log rank test). These data indicate that disseminated herpes zoster is amenable to therapy with either acyclovir or vidarabine; resultant mortality is low. 相似文献
73.
Diagnostic and prognostic factors in acute monocytic leukaemia: an analysis of 51 cases 总被引:1,自引:0,他引:1
Colin Stephen Scott Allistair N. Stark Howard J. Limbert Peter S. Master Christine Head Bryon E. Roberts 《British journal of haematology》1988,69(2):247-252
Diagnostic features (cytochemistry, immunophenotyping and serum biochemistry) were examined in 51 cases of acute monocytic leukaemia (AMoL). Peroxidase, Sudan black B and alpha naphthyl acetate esterase (ANAE) cytochemical reactions were unrelated to morphological (FAB groups M5a and M5b) or immunological subtype. ANAE cytochemistry, however, indicated that AMoL cases could be subdivided into those with typical (M-type) reactions and those with insignificant staining or monocytic ANAE isoenzymes (defined by IEF). All cases were phenotypically CD13/CD33 positive and, with one exception, had greater than 30% HLA-DR positive cells. Membrane CD14 expression was insignificant or variable in 33% of M5a cases in contrast to 23/24 M5b cases which showed high proportions of CD14-staining cells with at least two monoclonal antibodies. Serum lysozyme, LDH and beta-2 microglobulin (beta 2m) were increased in 88%, 68% and 81% of cases respectively but, with the exception of statistically higher lysozyme levels in CD14+ cases, were unrelated to the morphological, cytochemical or immunological diagnostic subgroups. Clinical and diagnostic features were also examined as possible prognostic indicators. The morphological, cytochemical and immunological subgroups of AMoL were not found to be of prognostic relevance but age (P = 0.004), renal failure (P = 0.005) and serum beta 2m levels (P = 0.002) were related to patient survival. Moreover, renal failure and serum beta 2m remained significant (P = 0.012 respectively) when age was taken into account and were shown to be independent prognostic variables. 相似文献
74.
Christian Massire Daelynn R. Buelow Sean X. Zhang Robert Lovari Heather E. Matthews Donna M. Toleno Raymond R. Ranken Thomas A. Hall David Metzgar Rangarajan Sampath Lawrence B. Blyn David J. Ecker Zhengming Gu Thomas J. Walsh Randall T. Hayden 《Journal of clinical microbiology》2013,51(3):959-966
Invasive fungal infections are a significant cause of morbidity and mortality among immunocompromised patients. Early and accurate identification of these pathogens is central to direct therapy and to improve overall outcome. PCR coupled with electrospray ionization mass spectrometry (PCR/ESI-MS) was evaluated as a novel means for identification of fungal pathogens. Using a database grounded by 60 ATCC reference strains, a total of 394 clinical fungal isolates (264 molds and 130 yeasts) were analyzed by PCR/ESI-MS; results were compared to phenotypic identification, and discrepant results were sequence confirmed. PCR/ESI-MS identified 81.4% of molds to either the genus or species level, with concordance rates of 89.7% and 87.4%, respectively, to phenotypic identification. Likewise, PCR/ESI-MS was able to identify 98.4% of yeasts to either the genus or species level, agreeing with 100% of phenotypic results at both the genus and species level. PCR/ESI-MS performed best with Aspergillus and Candida isolates, generating species-level identification in 94.4% and 99.2% of isolates, respectively. PCR/ESI-MS is a promising new technology for broad-range detection and identification of medically important fungal pathogens that cause invasive mycoses. 相似文献
75.
Lauren S Butler Eryn K Milian Amie DeVerna Kevin Latz Henry B Ellis Alexa R Martinez Kristin Hayden Christian Gerstenkorn Sara C Carpenito Charles W Wyatt Dai Sugimoto 《International Journal of Sports Physical Therapy》2021,16(2):312
BackgroundThree-dimensional (3D) motion analysis is considered the gold standard for evaluating human movement. However, its clinical utility is limited due to cost, operating expertise, and lengthy data processing time. Numerous qualitative scoring systems have been introduced to assess trunk and lower extremity biomechanics during functional tasks. However, the reliability of qualitative scoring systems to evaluate cutting movements is understudied. Purpose/Hypotheses: To assess the inter-rater and intra-rater reliability of the Cutting Alignment Scoring Tool (CAST) among sports medicine providers and to evaluate rater agreement of each component of the CAST. The hypotheses were: 1) there would be good–to-excellent inter-rater and intra-rater reliability among sports medicine providers, 2) there would be good to almost perfect agreement for cut width and trunk lean variables and moderate to good agreement for valgus variables of the CAST.Study DesignRepeated MeasuresMethodsTen videos of a 45-degree side-step cut performed by adolescent athletes were independently rated on two occasions by six raters (2 medical doctors, 2 physical therapists, and 2 athletic trainers). The variables assessed include trunk lean to the opposite direction of the cut, increased cut width, knee valgus at initial load acceptance (static), and knee valgus throughout the task (dynamic). Variables were scored as either present, which were given a score of “1”, or not present, which were given a score of “0”. Video sequence was randomized in each rating session, and a two-week wash out period was given.ResultsThe cumulative inter-rater and intra-rater reliabilities were good (ICC: 0.808 and ICC: 0.753). Almost perfect kappa coefficients were recorded for cut width (k=0.949). Moderate kappa coefficients were found for trunk lean (k= 0.632) and fair kappa coefficients were noted for dynamic and static valgus (k=0.462 and k= 0.533 respectively).ConclusionThese findings suggest that the CAST is a reliable tool to evaluate trunk and LE alignment during a cutting task by sports medicine providers.Level of EvidenceLevel 2 Diagnosis 相似文献
76.
Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone 下载免费PDF全文
Matthew J. Grosso Hayden‐William Courtland Xu Yang James P. Sutherland Kirsten Stoner Joseph Nguyen Anna Fahlgren F. Patrick Ross Marjolein C. H. van der Meulen Mathias P. Bostrom 《Journal of orthopaedic research》2015,33(2):163-173
77.
Tsutsumi YM Horikawa YT Jennings MM Kidd MW Niesman IR Yokoyama U Head BP Hagiwara Y Ishikawa Y Miyanohara A Patel PM Insel PA Patel HH Roth DM 《Circulation》2008,118(19):1979-1988
78.
79.
Heisler M Hofer TP Schmittdiel JA Selby JV Klamerus ML Bosworth HB Bermann M Kerr EA 《Circulation》2012,125(23):2863-2872
80.