全文获取类型
收费全文 | 41504篇 |
免费 | 2198篇 |
国内免费 | 164篇 |
专业分类
耳鼻咽喉 | 544篇 |
儿科学 | 921篇 |
妇产科学 | 715篇 |
基础医学 | 7970篇 |
口腔科学 | 932篇 |
临床医学 | 3179篇 |
内科学 | 7623篇 |
皮肤病学 | 1325篇 |
神经病学 | 4246篇 |
特种医学 | 1707篇 |
外科学 | 5763篇 |
综合类 | 204篇 |
一般理论 | 18篇 |
预防医学 | 2116篇 |
眼科学 | 915篇 |
药学 | 2921篇 |
中国医学 | 44篇 |
肿瘤学 | 2723篇 |
出版年
2022年 | 225篇 |
2021年 | 445篇 |
2020年 | 382篇 |
2019年 | 587篇 |
2018年 | 703篇 |
2017年 | 541篇 |
2016年 | 681篇 |
2015年 | 800篇 |
2014年 | 967篇 |
2013年 | 1400篇 |
2012年 | 2006篇 |
2011年 | 2175篇 |
2010年 | 1460篇 |
2009年 | 1369篇 |
2008年 | 2291篇 |
2007年 | 2352篇 |
2006年 | 2212篇 |
2005年 | 2332篇 |
2004年 | 2184篇 |
2003年 | 2111篇 |
2002年 | 2244篇 |
2001年 | 434篇 |
2000年 | 363篇 |
1999年 | 499篇 |
1998年 | 605篇 |
1997年 | 520篇 |
1996年 | 444篇 |
1995年 | 397篇 |
1994年 | 358篇 |
1993年 | 307篇 |
1992年 | 279篇 |
1991年 | 258篇 |
1990年 | 224篇 |
1989年 | 210篇 |
1988年 | 218篇 |
1987年 | 184篇 |
1985年 | 224篇 |
1984年 | 215篇 |
1983年 | 196篇 |
1982年 | 248篇 |
1981年 | 206篇 |
1933年 | 200篇 |
1932年 | 221篇 |
1931年 | 205篇 |
1930年 | 215篇 |
1929年 | 186篇 |
1928年 | 220篇 |
1927年 | 192篇 |
1926年 | 206篇 |
1925年 | 182篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Roselind Lieb Petra Zimmermann Robert H Friis Michael H?fler Sven Tholen Hans Ulrich Wittchen 《European psychiatry》2002,17(6):321-331
OBJECTIVE: Although somatoform disorders are assumed to be chronic clinical conditions, epidemiological knowledge on their natural course based on representative samples is not available. METHOD: Data come from a prospective epidemiologic study of adolescents and young adults in Munich, Germany. Respondents' diagnoses (N = 2548) at baseline and follow-up on average 42 months later are considered. The follow-up incidence, stability as well as selected baseline risk factors (sociodemographics, psychopathology, trauma exposure) for the incidence and stability of somatoform disorders and syndromes are prospectively examined. Diagnostic information was assessed by using the standardized Munich-Composite International Diagnostic Interview (M-CIDI). RESULTS: Over the follow-up period, incidence rate for any of the covered somatoform diagnoses was 25.7%. Stability for the overall group of any somatoform disorder/syndrome was 48%. Female gender, lower social class, the experience of any substance use, anxiety and affective disorder as well as the experience of traumatic sexual and physical threat events predicted new onsets of somatoform conditions, while stability was predicted by being female, prior existing substance use, affective and eating disorders as well as the experience of a serious accident. CONCLUSIONS: At least for a substantial proportion of individuals, the overall picture of somatization seems to be relatively stable, but with fluctuation in the symptom picture over time. Being female, the experience of substance use as well as anxiety disorder seem to constitute risk factors for the onset of new somatoform conditions as well as for a stable course over time. 相似文献
72.
Head-impulse testing in Fabry disease - vestibular function in male and female patients 总被引:1,自引:0,他引:1
Aim : To study the prevalence of peripheral vestibular deficit in male and female patients with Fabry disease and to assess the effect of enzyme replacement therapy (ERT) on peripheral vestibular function using quantitative head-impulse testing. Methods : Using dual search-coils the vestibulo-ocular reflex during rapid rotational head thrusts to both sides was recorded in 21 patients (13 male, 8 female) with Fabry disease prior to ERT initiation. ERT consisted of infusions of gene-activated human α-galactosidase A (agalsidase alfa; Replagal™) every 2 weeks at doses of 0.2mg/kg. Eight patients were tested again approximately 6 and 12 months after the initiation of ERT. Results : At baseline examination, 15 of the patients with Fabry disease (71%; 11 males, 4 females) showed reduced peripheral vestibular function. The deficit was unilateral in nine patients (3 females) and bilateral in six patients (1 female). The severity of the vestibular deficit was not significantly different between male and female patients. After 12 months of ERT, the average vestibular deficit on the weaker side tended to improve; however, the change was not significant ( p = 0.10).
Conclusion : Fabry disease affects peripheral vestibular function in both male and female patients. Females seem to be affected less frequently than males, but, on average, vestibular deficits are not different between the two groups. To confirm or reject the tendency for vestibular improvement during ERT, more patients need to be tested and longer follow-up periods are required. 相似文献
Conclusion : Fabry disease affects peripheral vestibular function in both male and female patients. Females seem to be affected less frequently than males, but, on average, vestibular deficits are not different between the two groups. To confirm or reject the tendency for vestibular improvement during ERT, more patients need to be tested and longer follow-up periods are required. 相似文献
73.
Repression is commonly assumed to be a major characteristic of the cancer-prone personality. Main supporting evidence includes studies showing that cancer patients are low in emotional expression and that repressives have shorter survival. The evidence did not seem compelling, mainly because of contrary findings, overlooking the age factor and the assessment instruments. Thus, we examined whether repression is a response to the threat posed by the cancer diagnosis and whether cancer patients are more repressive, using a new assessment method combining anxiety and defensiveness scores and controlling age. The subjects were 98 women comprising three groups comparable in demographic characteristics: (a) breast biopsy showed they were healthy (n = 40), (b) biopsy showed they had breast cancer (n = 32), and (c) underwent surgery unrelated to cancer (n = 26). Only post-surgery groups a and b knew the diagnosis. Questionnaires of information and repression were administered to all women pre- and post-surgery. Before surgery, the groups did not differ in repression, anxiety and defensiveness. Post-surgery, there were no differences in anxiety but MANOVA and X2 analyses showed that, in the malignancy group, defensiveness and the number of repressors increased more than in the other groups. The results indicate that repression could be a response to the threat posed by the cancer diagnosis and a means for keeping anxiety at a tolerable level rather than a personality trait of cancer patients. 相似文献
74.
75.
Antidepressant-associated maniform states in acute treatment of patients with bipolar-I depression 总被引:2,自引:0,他引:2
R. Bottlender Daniel Rudolf Anton Strauss Hans-Jürgen Möller 《European archives of psychiatry and clinical neuroscience》1998,248(6):296-300
Medical records of 158 patients with bipolar depression were analysed for the incidence of a switch from depression to maniform
states (mania and hypomania). Relation to psychopharmacological treatment was investigated. Thirty-nine (25%) patients of
the total sample had switched to a maniform state during the treatment period in the hospital. Among that group the phenomenon
occurred in 23 patients (15%) as a hypomania and in 16 patients (10%) as a mania. Patients with a switch were significantly
more often treated with tricyclic antidepressants (TCA) than patients without switch (79.5% vs 51.3%). Mood stabilising medication
might reduce the risk for switching, especially in patients treated with TCA; however, it seems not totally sufficient, since
59% of the switched patients received mood stabilisers. The switch phenomenon was not associated with sociodemographic or
clinical data.
Received: 23 September 1998 / Accepted: 28 September 1998 相似文献
76.
Angelika Heese Ulrike Lacher Hans Uwe Koch Janna Kubosch Yasmin Ghane Klaus-Peter Peters 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1996,47(11):817-824
Zusammenfassung
Die Typ I-Allergien gegen Latex sind in den vergangenen Jahren zu einem zunehmenden berufsdermatologischen Problem geworden,
zumal mindestens 10% der Angestellten im Gesundheitswesen betroffen sind. In der Dermatologischen Klinik der Universit?t Erlangen-Nürnberg
stieg die Anzahl der j?hrlich diagnostizierten Patienten mit Latexallergien von 1989 bis 1995 auf das 12fache, wobei der Anteil
der schweren, generalisierten Formen der Erkrankung von 10,7% (1989/1990) auf 44% (1994/1995) zunahm.
Unter den m?glichen Ausl?sern der Latexallergie (wasserl?sliche Proteine mit Molekulargewichten von 2 bis 200 kD) sind mindestens
5 Hauptproteine mit bereits bekannter Prim?rstruktur zu berücksichtigen. Zus?tzlich gibt es Hinweise für Markerproteine, die
in bestimmten Risikogruppen geh?uft zur Ausl?sung spezifischer IgE-Antik?rper führen (z.B. 46 kD-Protein in medizinischen
Berufen, 14,6 kD- und 27 kD-Proteine bei Kindern mit Spina bifida). Das Vorkommen von Kreuzreaktionen zwischen Latex und unterschiedlichen
Früchten (besonders Avocado, Kiwi, Banane, E?kastanie) bei 60 bis 70% der Latexallergiker ist bei der allergologischen Abkl?rung
und Beratung dieser Patienten zu beachten. Wesentliche Aspekte der Prophylaxe umfassen die konsequente Umstellung medizinischer
Einrichtungen auf ungepuderte Latexhandschuhe mit niedrigem Proteingehalt. Eine Zusammenstellung von OP- und Untersuchungshandschuhen,
welche Angaben über die von uns ermittelten Proteinkonzentrationen (modifizierte Lowry-Methode und Hochdruck-Flüssigkeits-Chromatographie,
HPLC) enth?lt, soll ein Leitfaden bei der Auswahl allergologisch geeigneter Handschuhe sein.
Eingegangen am 10. August 1996 Angenommen am 21. August 1996 相似文献
77.
Intramolecular Aminoalkylation of Amidoximes 2-tertiary aminobenzamidoximes 2 react with mercury edta by intramolecular aminoalkylation and oxidation to anellated quinazolinone-oximes 5 ; their configuration is not changed. 相似文献
78.
Hans C. Andersson Dilys M. Parry John J. Mulvihill 《American journal of medical genetics. Part A》1995,56(1):72-75
Hereditary lymphedemas that are not associated with other malformations usually affect the lower limbs and are inherited in an autosomal dominant fashion. These non-syndromic hereditary lymphedemas are categorized by their age of onset, being either congenital (Milroy disease) or having an onset in childhood or around puberty (Meige disease). We describe a family in which three individuals in three generations had unusually late onset of lym-phedema in their mid-twenties or thirties. The proband additionally developed a very rare lymphangiosarcoma. This tumor, usually associated with post-mastectomy lym-phedema, has not been described in late-onset hereditary lymphedema. Because of an unusually high incidence of multiple primary tumors in association with lymphangiosarcoma in the literature (approximately 10%) and the proband's own familial cancer background, we speculate that an inherited predisposition to malignancy may underlie the development of lymphedema-associated lymphangiosarcoma. © 1995 Wiley-Liss, Inc. 相似文献
79.
Posterior dislocations of the sternoclavicular joint are uncommon, but are potentially quite serious. Radiologic diagnosis and management are frequently difficult. The specialized projections available are not widely known, and the role of plain films is poorly understood. The incidence, pathomechanics, and clinical manifestations of such dislocations are presented and the radiologic diagnosis is discussed. 相似文献
80.
Mark Hans Emanuel M.D. Augustinus Hart M.Sc. Kees Wamsteker M.D. Frits Lammes M.D. 《Fertility and sterility》1997,68(5):881-886
Objective: To determine the contribution of several variables to fluid loss during transcervical resection of submucous myomas.Design: An observational study using multiple linear regression analyses.Setting: A university-affiliated training hospital and a university department of clinical epidemiology and biostatistics.Patient(s): Patients with submucous myomas.Intervention(s): Transcervical resection of submucous myomas and monitoring of fluid loss.Main Outcome Measure(s): Patient age, uterine enlargement, treatment with GnRH analogues or 8-ornithine-vasopressin, type of anesthesia, number of myomas, intramural extension of the myoma (type of myoma), and operating time were tested as variables.Result(s): Only intramural extension of the myoma and operating time were obviously related to fluid loss. For the other variables, such a relation was weak at best. The relation between fluid loss and operating time was not modified by any of the other variables.Conclusion(s): Because fluid loss is an important limiting factor in the transcervical resection of submucous myomas, special attention should be paid to reduction of the operating time and preoperative assessment of the intramural extension of the myoma to guide appropriate patient selection. 相似文献