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Corneel Coens Stefan Suciu Vanna Chiarion-Sileni Jean-Jacques Grob Reinhard Dummer Jedd D Wolchok Henrik Schmidt Omid Hamid Caroline Robert Paolo A Ascierto Jon M Richards Celeste Lebbé Virginia Ferraresi Michael Smylie Jeffrey S Weber Michele Maio Andrew Bottomley Srividya Kotapati Alexander M M Eggermont 《The lancet oncology》2017,18(3):393-403
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Beneficial effects of replacing diet beverages with water on type 2 diabetic obese women following a hypo‐energetic diet: A randomized, 24‐week clinical trial 下载免费PDF全文
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Kristyn A. Bates Hamid R. Sohrabi Stephanie R. Rainey-Smith Michael Weinborn Romola S. Bucks Mark Rodrigues 《The International journal of neuroscience》2017,127(3):243-252
Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n = 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p < .05 and F = 3.2670; p < .05, respectively). Conclusion: Our cross-sectional findings suggest that the positive effect of HDL-C on verbal memory may be present much earlier than previously reported and provide further support for the role of HDL-C in healthy brain ageing. Further exploration of the protective effect of HDL-C on cognitive function in ageing is warranted through follow-up, longitudinal studies. 相似文献
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Hamid Farhangi Zahra Badiei Hasan Mottaghi Moghaddam Mohammad Reza Keramati 《Indian journal of hematology & blood transfusion》2017,33(2):228-234
Accumulation of excess iron in heart can lead to cardiac dysfunction, which is the most common cause of death in thalassemia major patients. Biopsy is an invasive procedure and therefore not an ideal option to assess iron load. However, standard/usual non-invasive methods, such as ferritin measurement, have some limitations and the results show poor correlations with iron load. Magnetic Response Imaging (MRI-T2*), as a non-invasive and reliable method for iron load assessment in organs such as liver and heart, can be suggested as a favorable alternative. This cross-sectional study was implemented in Thalassemia and Hemophilia Clinic Center (Sarvar) affiliated with Mashhad University of Medical Sciences, Mashhad, Iran, from 2012 to 2013. After the approval of the research protocol by the local ethic committee, laboratory tests, including CBC and serum ferritin, were carried out, and echocardiography and heart and liver MRI-T2* were performed. All statistical analysis was done through SPSS software (version 11.5), using independent sample t test and Pearson’s correlation coefficient test. A P value ≤0.05 was considered to be significant. 88 patients with the mean (±SD) age of 21.2 (±5.6) years, (range 11–37 years) were observed. Iron load was assessed using MRI-T2* with the following results: Out of 88 patients, 48.9 % had mild to severe cardiac siderosis, and 75.2 % had mild to severe liver siderosis. We demonstrated a correlation between liver MRI-T2* and serum ferritin, and heart MRI-T2* and ejection fraction. However, no correlation between liver and heart MRI-T2* was observed. Heart and liver siderosis is a common and serious problem in thalassemia major patients, and MRI-T2* as a sensitive and non-invasive technique can be used for early/timely detection of siderosis and good therapeutic monitoring in these patients. 相似文献
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Correlates of methamphetamine use among young Iranians: Findings of a population‐based survey in 2013 下载免费PDF全文
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Afsaneh Tehranian Roghayeh Hassani Zangbar Faezeh Aghajani Mahdi Sepidarkish Saeedeh Rafiei Tayebe Esfidani 《Gynecological surgery》2017,14(1):17